Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jason D Matthews"'
Autor:
Shanta Murthy, Murugadas Anbazhagan, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Ranjit Pelia, David J. Cutler, Jason D. Matthews, Subra Kugathasan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Perianal fistulizing Crohn’s disease (CD) is a severe gastrointestinal disorder causing extensive mucosal damage with limited treatment options. Severe manifestations of the disease appear at higher rates in non-Europeans but the genetic a
Externí odkaz:
https://doaj.org/article/9e986aae16f04da0b37b685264521a99
PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells
Autor:
Murugadas Anbazhagan, Garima Sharma, Shanta Murthy, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Amanda Randunne, David J. Cutler, Subra Kugathasan, Jason D. Matthews
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background The prostaglandin receptor PTGER4 facilitates homeostasis in the gut. Previous reports indicate that goblet cells, marked by SPINK4 expression, might be affected by PTGER4 activity. Current evidence suggests that prostaglandin E2
Externí odkaz:
https://doaj.org/article/703b6ce950e24a41929fb944510436e4
Autor:
Savannah Washburn, Sushma C. Maddipatla, Shanta Murthy, Anne Dodd, Ranjit S. Pelia, Vasantha L. Kolachala, Duke Geem, Jason D. Matthews, Greg Gibson, Subra Kugathasan
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 1, Pp 131-133 (2024)
Externí odkaz:
https://doaj.org/article/96f777f86aa246ff991fdc1a1c2d227a
Autor:
Suresh Venkateswaran, Hari K. Somineni, Jason D. Matthews, Varun Kilaru, Jeffrey S. Hyams, Lee A. Denson, Richard Kellamayer, Greg Gibson, David J. Cutler, Karen N. Conneely, Alicia K. Smith, Subra Kugathasan
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) pati
Externí odkaz:
https://doaj.org/article/775c2f58680944ca846097a854389076
Autor:
Ranjit Pelia, Suresh Venkateswaran, Jason D. Matthews, Yael Haberman, David J. Cutler, Jeffrey S. Hyams, Lee A. Denson, Subra Kugathasan
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Crohn’s disease (CD) is a heritable chronic inflammatory disorder. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation by affecting gene expression, but can also directly affect protein function, thus having
Externí odkaz:
https://doaj.org/article/985f433f52b8425b84594cdba42bea7c
Autor:
Barbara Joanna Niklinska-Schirtz, Suresh Venkateswaran, Murugadas Anbazhagan, Vasantha L. Kolachala, Jarod Prince, Anne Dodd, Raghavan Chinnadurai, Gregory Gibson, Lee A. Denson, David J. Cutler, Anil G. Jegga, Jason D. Matthews, Subra Kugathasan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1267-1280 (2021)
Background & Aims: We used patient-derived organoids (PDOs) to study the epithelial-specific transcriptional and secretome signatures of the ileum during Crohn’s disease (CD) with varying phenotypes to screen for disease profiles and potential drug
Externí odkaz:
https://doaj.org/article/138e1bb610ec4c1a92016aaad7d4e59a
Autor:
Trevor M. Darby, Joshua A. Owens, Bejan J. Saeedi, Liping Luo, Jason D. Matthews, Brian S. Robinson, Crystal R. Naudin, Rheinallt M. Jones
Publikováno v:
iScience, Vol 12, Iss , Pp 356-367 (2019)
Summary: The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such claims remains limited. We address this gap by identifying a beneficial bacterium
Externí odkaz:
https://doaj.org/article/711b1f38f787445d962489da4175aaad
Autor:
Jason D. Matthews, April R. Reedy, Huixia Wu, Benjamin H. Hinrichs, Trevor M. Darby, Caroline Addis, Brian S. Robinson, Young-Mi Go, Dean P. Jones, Rheinallt M. Jones, Andrew S. Neish
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 526-532 (2019)
Intestinal homeostasis is regulated in-part by reactive oxygen species (ROS) that are generated in the colonic mucosa following contact with certain lactobacilli. Mechanistically, ROS can modulate protein function through the oxidation of cysteine re
Externí odkaz:
https://doaj.org/article/9f5023c7678749618cba0f3b0b041aa1
Autor:
Murugadas Anbazhagan, Duke Geem, Suresh Venkateswaran, Ranjit Pelia, Vasantha L Kolachala, Anne Dodd, Sushma C Maddipatla, David J Cutler, Jason D Matthews, Raghavan Chinnadurai, Subra Kugathasan
Publikováno v:
Stem Cells Translational Medicine. 12:112-122
Therapy with mesenchymal stromal cells (MSCs) has shown promise in inflammatory bowel disease—leveraging their immunosuppressive and regenerative properties. However, the potential immunogenic complications of allogenic MSCs sourced from different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5e3f00e0e17a0e53522c09e8d743590
https://doi.org/10.1093/stcltm/szad003
https://doi.org/10.1093/stcltm/szad003
Autor:
Suresh Venkateswaran, David J. Cutler, Lee A. Denson, Jeffrey S. Hyams, Jason D. Matthews, Yael Haberman, Subra Kugathasan, Ranjit S. Pelia
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-15 (2021)
BMC Medical Genomics
BMC Medical Genomics
Background Crohn’s disease (CD) is a heritable chronic inflammatory disorder. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation by affecting gene expression, but can also directly affect protein function, thus having a substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb387fe786bc5d699c466fc0fb8d0561
https://doaj.org/article/985f433f52b8425b84594cdba42bea7c
https://doaj.org/article/985f433f52b8425b84594cdba42bea7c