Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jason D, Hughes"'
Autor:
Simone Sciabola, Hualin Xi, Dario Cruz, Qing Cao, Christine Lawrence, Tianhong Zhang, Sergio Rotstein, Jason D Hughes, Daniel R Caffrey, Robert V Stanton
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0238753 (2021)
PFRED a software application for the design, analysis, and visualization of antisense oligonucleotides and siRNA is described. The software provides an intuitive user-interface for scientists to design a library of siRNA or antisense oligonucleotides
Externí odkaz:
https://doaj.org/article/be263efdf1364ef8aaa493f2ff09ba77
Autor:
Matthew K. Howe, Kennichi Dowdell, Amitava Roy, Julie E. Niemela, Wyndham Wilson, Joshua J. McElwee, Jason D. Hughes, Jeffrey I. Cohen
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Interleukin-2-inducible T cell kinase (ITK) is critical for T cell signaling and cytotoxicity, and control of Epstein-Barr virus (EBV). We identified a patient with a novel homozygous missense mutation (D540N) in a highly conserved residue in the kin
Externí odkaz:
https://doaj.org/article/8d21737dd3e54543aa8b76ed89880070
Autor:
Jinzhuang Dou, Baoluo Sun, Xueling Sim, Jason D Hughes, Dermot F Reilly, E Shyong Tai, Jianjun Liu, Chaolong Wang
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1007021 (2017)
Knowledge of biological relatedness between samples is important for many genetic studies. In large-scale human genetic association studies, the estimated kinship is used to remove cryptic relatedness, control for family structure, and estimate trait
Externí odkaz:
https://doaj.org/article/18abb2fed8274791bc33f3d55e65b808
Autor:
Nicholas Murgolo, Zhimei Du, Robin S Ehrick, Jason D. Hughes, Guanghua Benson Li, Nihal Tugcu, Richard C. Stevens, Eric J Wallenstein, Jia Zhao, Jorge Quiroz, Matthew Manahan, Ren Liu, Yung-Shyeng Tsao, David Pollard, Jennifer M. Pollard, Michael C Nelson
Publikováno v:
Biotechnology progressREFERENCES. 38(1)
In recent years, assurance of clonality of the production cell line has been emphasized by health authorities during review of regulatory submissions. When insufficient assurance of clonality is provided, augmented control strategies may be required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad30f0dcf2ecf8f441813bca0f6ba820
https://pubmed.ncbi.nlm.nih.gov/34586757
https://pubmed.ncbi.nlm.nih.gov/34586757
Autor:
Jason D. Hughes, Daniel R. Caffrey, Simone Sciabola, Dario Cruz, Tianhong Zhang, Qing Cao, Robert V. Stanton, Hualin Xi, Sergio Rotstein, Christine Lawrence
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0238753 (2021)
PLoS ONE
PLoS ONE
PFRED a software application for the design, analysis, and visualization of antisense oligonucleotides and siRNA is described. The software provides an intuitive user-interface for scientists to design a library of siRNA or antisense oligonucleotides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae3d6cc288481e3e327c9452193e92d
https://doaj.org/article/be263efdf1364ef8aaa493f2ff09ba77
https://doaj.org/article/be263efdf1364ef8aaa493f2ff09ba77
Autor:
Jason D. Hughes, Monkol Lek, Seva Kashin, Steven A. McCarroll, Giulio Genovese, Daniel G. MacArthur, Robert E. Handsaker, Michael J. Lenardo, Joshua McElwee, Christopher W. Whelan
Two intriguing forms of genome structural variation (SV) – dispersed duplications, and de novo rearrangements of complex, multi-allelic loci – have long escaped genomic analysis. We describe a new way to find and characterize such variation by ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26eacf744768d819f6c5d1c83ea08b81
https://doi.org/10.1101/2020.08.03.235358
https://doi.org/10.1101/2020.08.03.235358
Autor:
Ryan Woodhouse, Dan Stover, Lucas Dennis, Meijuan Li, Christine Burns, David Delfosse, Jason D. Hughes, Brian M. Alexander, Priti Hegde, Ninad Dewal, Joel Skoletsky, Coren Milbury, Travis A. Clark, Amy Donahue, Mark Kennedy, Wei Meng, Jennifer Dacpano-Komansky, Christine Vietz, Pei Ma
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237802 (2020)
PLoS ONE
PLoS ONE
As availability of precision therapies expands, a well-validated circulating cell-free DNA (cfDNA)-based comprehensive genomic profiling assay has the potential to provide considerable value as a complement to tissue-based testing to ensure potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9da6b8079b1bf0a06147432a85460c
https://doaj.org/article/c9d36c35db194ad48647b611d39f7516
https://doaj.org/article/c9d36c35db194ad48647b611d39f7516
Autor:
Jason D. Hughes, Michael Coyne, Doron Lipson, Jie He, Erica B. Schleifman, Philip J. Stephens, Mark Bailey, Allison Welsh, Jeffrey S. Ross, Jill M. Spoerke, Travis A. Clark, Vincent A. Miller, Eric Peters, Jeffrey P. Gregg, Garrett M. Frampton, Daniel S. Lieber, Dean Pavlick, Amy Donahue, Steven Roels, Tim Brennan, Jon Chung, Geneva Young, Tariq I Mughal, Siraj M. Ali, Mark Kennedy, Geoff Otto, Mark R. Lackner, Niru Chennagiri, Mandy Zhao, Bernard Fendler, Steven Gendreau, Virginia Breese, Shan Zhong, Alyssa Tsiros, Lauren Young
Publikováno v:
The Journal of Molecular Diagnostics : JMD
Genomic profiling of circulating tumor DNA derived from cell-free DNA (cfDNA) in blood can provide a noninvasive method for detecting genomic biomarkers to guide clinical decision making for cancer patients. We developed a hybrid capture–based next
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef10b33682d3729f780da7a658a3a47
http://europepmc.org/articles/PMC6593250
http://europepmc.org/articles/PMC6593250
Autor:
Daniel R Caffrey, Juan Zhao, Zhili Song, Michael E Schaffer, Steven A Haney, Romesh R Subramanian, Albert B Seymour, Jason D Hughes
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21503 (2011)
Small interfering RNAs (siRNAs) are routinely used to reduce mRNA levels for a specific gene with the goal of studying its function. Several studies have demonstrated that siRNAs are not always specific and can have many off-target effects. The 3' UT
Externí odkaz:
https://doaj.org/article/80e4e30b2ce941189f40e0e34dd04ae8
Autor:
Christine Vietz, Meijuan Li, Kimberly McGregor, Ole Gjoerup, Russell Madison, Brennan Decker, Aparna Aiyer, Geoffrey R. Oxnard, Lei Yang, Jason D. Hughes, Priti Hegde, Bernard Fendler
Publikováno v:
Cancer Research. 81:2231-2231
Background: F1LCDx is an FDA-approved liquid biopsy test offering pan-tumor profiling of >300 genes with CDx indications for multiple cancer types. One key limitation is that sensitivity for detection of genomic alterations in ctDNA is impaired when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5802a551b4be8ca9b34bdcf50fc2fd1
https://doi.org/10.1158/1538-7445.am2021-2231
https://doi.org/10.1158/1538-7445.am2021-2231