Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Jason Crain"'
Autor:
Jonathan G. Terry, Anthony J. Walton, Chaker Tlili, Ilenia Ciani, Stuart W. J. Ember, Alan J. Ross, Mizanur R. Khondoker, Peter Ghazal, Andrew R. Mount, Colin J. Campbell, Till T. Bachmann, Gerard Giraud, Holger Schulze, Jason Crain
Publikováno v:
International Journal of Molecular Sciences, Vol 10, Iss 4, Pp 1930-1941 (2009)
Quantum dot (QD) labeling combined with fluorescence lifetime imaging microscopy is proposed as a powerful transduction technique for the detection of DNA hybridization events. Fluorescence lifetime analysis of DNA microarray spots of hybridized QD l
Externí odkaz:
https://doaj.org/article/5d5e4d5e2839426f84fd10805e08aed3
Autor:
Linda X. Phan, Victor Cruces Chamorro, Hector Martinez-Seara, Jason Crain, Mark S.P. Sansom, Stephen J. Tucker
Publikováno v:
Biophysical Journal. 122:1548-1556
The functional properties of some biological ion channels and membrane transport proteins are proposed to exploit anion-hydrophobic interactions. Here, we investigate a chloride-pumping rhodopsin (ClR) as an example of a membrane protein known to con
Autor:
Valeria Losasso, Khushbu Agarwal, Morris Waskar, Amitabha Majumdar, Jason Crain, Martyn Winn, Michael Hoptroff
Publikováno v:
Biophysical Journal. 121:491-501
The skin-associated microbiome plays an important role in general well-being and in a variety of treatable skin conditions. In this regard, endogenous antimicrobial peptides have both a direct and indirect role in determining the composition of the m
Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces
Since its emergence, the Covid19 pandemic has been sustained by a series of transmission waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher transmissivity and/or increased disease severity. Here we use molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe674766d0dfe5ab2ee88e6c002727cc
https://doi.org/10.1101/2022.12.20.521221
https://doi.org/10.1101/2022.12.20.521221
Publikováno v:
Biophysical Journal. 122:112a-113a
Autor:
Lewis W. Anderson, Martin Kiffner, Panagiotis Kl. Barkoutsos, Ivano Tavernelli, Jason Crain, Dieter Jaksch
Variational quantum algorithms (VQAs) are increasingly being applied in simulations of strongly-bound (covalently bonded) systems using full molecular orbital basis representations. The application of quantum computers to the weakly-bound intermolecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186705ce8d62fe4e1c04b5b3cbf7f8ac
https://ora.ox.ac.uk/objects/uuid:b443e8d3-19b2-44e4-82f6-551b5dd0f91d
https://ora.ox.ac.uk/objects/uuid:b443e8d3-19b2-44e4-82f6-551b5dd0f91d
Autor:
Vijil Chenthamarakshan, Samuel Hoffman, C. David Owen, Petra Lukacik, Claire Strain-damerell, Daren Fearon, Tika Malla, Anthony Tumber, Christopher Schofield, Helen Duyvesteyn, Wanwisa Ddejnirattisai, Loic Carrique, Thomas Walter, Gavin Screaton, Tetiana Matviyuk, Aleksandra Mojsilovic, Jason Crain, Martin Walsh, David Stuart, Payel Das
The COVID-19 pandemic has highlighted the urgency for developing more efficient molecular discovery pathways. As exhaustive exploration of the vast chemical space is infeasible, discovering novel inhibitor molecules for emerging drug-target proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7e450c90346533d91027662255fb83b
https://doi.org/10.21203/rs.3.rs-1648691/v1
https://doi.org/10.21203/rs.3.rs-1648691/v1
Autor:
Aleksandra Mojsilovic, Cicero Nogueira dos Santos, James L. Hedrick, Jason Crain, Sebastian Gehrmann, Kahini Wadhawan, Flaviu Cipcigan, Inkit Padhi, Hendrik Strobelt, Yi Yan Yang, Pin-Yu Chen, Payel Das, Jeremy P. K. Tan, Vijil Chenthamarakshan, Tom Sercu
Publikováno v:
Nature Biomedical Engineering. 5:613-623
The de novo design of antimicrobial therapeutics involves the exploration of a vast chemical repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report an efficient computational method for the generation of antimicrob
Autor:
Leonardo De Maria, Ekaterina L. Ratkova, Flaviu Cipcigan, Paul Smith, Jason Crain, Anders Hogner, Antonio Llinas
Publikováno v:
Journal of Chemical Information and Modeling. 61:263-269
Cyclic peptides have the potential to bind to challenging targets, which are undruggable with small molecules, but their application is limited by low membrane permeability. Here, using a series of cyclic pentapeptides, we showed that established phy
Publikováno v:
ACS Nano. 14:8616-8623
Water provides the driving force for the assembly and stability of many cellular components. Despite its impact on biological functions, a nanoscale understanding of the relationship between its structure and dynamics under soft confinement has remai