Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jason Corbin"'
Autor:
Hao Chen, Nghi H. Nguyen, Charlene M. Magtoto, Simon A. Cobbold, Grace M. Bidgood, Lizeth G. Meza Guzman, Lachlan W. Richardson, Jason Corbin, Amanda E. Au, Bernhard C. Lechtenberg, Rebecca Feltham, Kate D. Sutherland, Christoph Grohmann, Sandra E. Nicholson, Brad E. Sleebs
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102552- (2023)
The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway senses reactive oxygen species and regulates cellular oxidative stress. Inhibiting KEAP1 to activate the NRF2 antioxidant response
Externí odkaz:
https://doaj.org/article/8bf601d4ee3e4a67b3cbbfafd936ded8
Autor:
Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M. Murphy, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Warren S. Alexander, Emma C. Josefsson
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). Previous studies suggested a role for the necroptotic machinery in platelets, where loss of MLKL or its upstream
Externí odkaz:
https://doaj.org/article/f37f0075e07d4c99befb53fb3fbfba5e
Autor:
Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providin
Externí odkaz:
https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd
Autor:
James A Rickard, Holly Anderton, Nima Etemadi, Ueli Nachbur, Maurice Darding, Nieves Peltzer, Najoua Lalaoui, Kate E Lawlor, Hannah Vanyai, Cathrine Hall, Aleks Bankovacki, Lahiru Gangoda, Wendy Wei-Lynn Wong, Jason Corbin, Chunzi Huang, Edward S Mocarski, James M Murphy, Warren S Alexander, Anne K Voss, David L Vaux, William J Kaiser, Henning Walczak, John Silke
Publikováno v:
eLife, Vol 3 (2014)
SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm mutation causes TNF-dependent multi-organ inflammation, characterized by
Externí odkaz:
https://doaj.org/article/dc7dcb5894674dcf8834bbc332067b93
Autor:
Amanda E. Au, Jason Corbin, Marion Lebois, Pradnya Gangatirkar, Fatme Yassinson, Stephanie R. Hyslop, Ping Cannon, Kylie D. Mason, Connie S. N. Li-Wai-Suen, Alexandra L. Garnham, Diane Moujalled, Luisa Cimmino, Warren S. Alexander, Emma C. Josefsson
Publikováno v:
Blood Advances. 7:1560-1571
Platelets have been shown to enhance the survival of lymphoma cell lines. However, it remains unclear whether they play a role in lymphoma. Here, we investigated the potential role of platelets and/or megakaryocytes in the progression of Eμ-myc lymp
Autor:
Marnie E. Blewitt, Douglas J. Hilton, Warren S. Alexander, Gordon K. Smyth, Ian J. Majewski, James M. Murphy, Miha Pakusch, Jason Corbin, Stanley Lee, Yifang Hu, Kelan Chen, Huei San Leong
Supplementary Material PDF file - 709K, Supplementary Tables 1 and 2, supplementary methods, supplementary figure legends and supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55111f649031bfd4f5f7e664a7ea78d5
https://doi.org/10.1158/0008-5472.22398279.v1
https://doi.org/10.1158/0008-5472.22398279.v1
Autor:
Marnie E. Blewitt, Douglas J. Hilton, Warren S. Alexander, Gordon K. Smyth, Ian J. Majewski, James M. Murphy, Miha Pakusch, Jason Corbin, Stanley Lee, Yifang Hu, Kelan Chen, Huei San Leong
Supplementary Tables S3-S4 XLSX file - 576K, Gene set analysis (Camera) and differentially expressed genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1826c40b4776a691d89e58e2f08c66cb
https://doi.org/10.1158/0008-5472.22398276
https://doi.org/10.1158/0008-5472.22398276
Autor:
Stephanie R. Hyslop, Pradnya Gangatirkar, Ariena Kersbergen, Ashley P. Ng, Warren S. Alexander, Marliese Alexander, Jason Corbin, Alesha A. Thai, Andrew J. Kueh, Marco J Herold, Kate D. Sutherland, Emma C. Josefsson, Benjamin J. Solomon
Publikováno v:
Oncogene. 39:5177-5186
Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimental transplantation of cancer cell lines has uncovered a role for platelets in blood-borne metastasis. These studies, howe
Autor:
Cody C. Allison, Benjamin T. Kile, Esme C. Hatchell, Maria Kozlovskaia, Catriona McLean, Pradnya Gangatirkar, Gabriela Brumatti, Marc Pellegrini, Pamela A. McCombe, Julie Sheridan, Donald Metcalf, Klaus Warnatz, Natasha Silke, Maria C. Tanzer, Janelle E. Collinge, Seth L. Masters, Victoria E. Jackson, Jason Corbin, David B. Ascher, Dina Stockwell, Nicole Vlahovich, Zhixiu Li, James M. Murphy, Carola G. Vinuesa, Maria Kauppi, Ronald M. Laxer, John Reveille, Adrienne A. Hilton, John Silke, Ian J. Majewski, David Hughes, Gillian M. Tannahill, Melanie Bahlo, Christine Biben, Michael A. Silk, Maria A. Fiatarone Singh, Cathrine Hall, Peter E. Czabotar, Jian-Guo Zhang, Polly J. Ferguson, Sukhdeep K Spall, Carolyn A. de Graaf, Michael D. Stutz, Nils Venhoff, Alexander G. Bassuk, Zikou Liu, Holly Anderton, Michael S. Hildebrand, Tracy A. Willson, James A Rickard, Hiroyasu Nakano, Vicki Athanasopoulos, Matthew A. Brown, Samuel N. Young, Jens Thiel, Emma J. Petrie, Diep Chau, Sarah E Garnish, Sanae Miyake, Anne Tripaydonis, Warren S. Alexander, Allison Cox, Stefan Blum, Joanne M Hildebrand, Thomas S. Scerri, Kristin A Rigbye, Leila N. Varghese, Benjamin W. Darbro, Emma C. Josefsson, Ladina Di Rago
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
NATURE COMMUNICATIONS
Nature Communications
NATURE COMMUNICATIONS
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, MlklD139V, that alters the two-helix ‘brace’ that connects the killer four-helix bundle and reg
Autor:
Maria Kauppi, Jason Corbin, Najoua Lalaoui, Marion Lebois, Diane Moujalled, Joanne M Hildebrand, Pradnya Gangatirkar, James M. Murphy, Warren S. Alexander, John Silke, Emma C. Josefsson
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 1, Pp 1-17 (2021)
Cell Death and Disease, Vol 12, Iss 1, Pp 1-17 (2021)
Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). Previous studies suggested a role for the necroptotic machinery in platelets, where loss of MLKL or its upstream regulato