Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jason Coppell"'
Autor:
Zijian Fang, Giuditta Corbizi Fattori, Thomas McKerrell, Rebecca H. Boucher, Aimee Jackson, Rachel S. Fletcher, Dorian Forte, Jose-Ezequiel Martin, Sonia Fox, James Roberts, Rachel Glover, Erica Harris, Hannah R. Bridges, Luigi Grassi, Alba Rodriguez-Meira, Adam J. Mead, Steven Knapper, Joanne Ewing, Nauman M. Butt, Manish Jain, Sebastian Francis, Fiona J. Clark, Jason Coppell, Mary F. McMullin, Frances Wadelin, Srinivasan Narayanan, Dragana Milojkovic, Mark W. Drummond, Mallika Sekhar, Hesham ElDaly, Judy Hirst, Maike Paramor, E. Joanna Baxter, Anna L. Godfrey, Claire N. Harrison, Simón Méndez-Ferrer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Current therapies for myeloproliferative neoplasms (MPNs) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem/progenitor cells (HSPCs). TAMARIN Pha
Externí odkaz:
https://doaj.org/article/16a1a95232b2462f94a84a299c0e1020
Autor:
Thomas Coats, Daniel Bean, Theodora Vatopoulou, Dhanapal Vijayavalli, Razan El‐Bashir, Aikaterini Panopoulou, Henry Wood, Manujasri Wimalachandra, Jason Coppell, Patrick Medd, Michelle Furtado, David Tucker, Austin Kulasakeraraj, Joya Pawade, Richard Dobson, Robin Ireland
Publikováno v:
eJHaem, Vol 2, Iss 2, Pp 261-265 (2021)
Abstract Accurate, reproducible diagnoses can be difficult to make in haemato‐oncology due to multi‐parameter clinical data, complex diagnostic criteria and time‐pressured environments. We have designed a decision tree application (DTA) that re
Externí odkaz:
https://doaj.org/article/45e62cae9a9544e3a2d18f39fb0be3a7
Autor:
Claire N. Harrison, Jyoti Nangalia, Rebecca Boucher, Aimee Jackson, Christina Yap, Jennifer O'Sullivan, Sonia Fox, Isaak Ailts, Amylou C. Dueck, Holly L. Geyer, Ruben A. Mesa, William G. Dunn, Eugene Nadezhdin, Natalia Curto-Garcia, Anna Green, Bridget Wilkins, Jason Coppell, John Laurie, Mamta Garg, Joanne Ewing, Steven Knapper, Josephine Crowe, Frederick Chen, Ioannis Koutsavlis, Anna Godfrey, Siamak Arami, Mark Drummond, Jennifer Byrne, Fiona Clark, Carolyn Mead-Harvey, Elizabeth Joanna Baxter, Mary Frances McMullin, Adam J. Mead
Publikováno v:
Harrison, C N, Nangalia, J, Boucher, R, Jackson, A, Yap, C, O'Sullivan, J, Fox, S, Ailts, I, Dueck, A C, Geyer, H L, Mesa, R A, Dunn, W G, Nadezhdin, E, Curto-Garcia, N, Green, A, Wilkins, B, Coppell, J, Laurie, J, Garg, M, Ewing, J, Knapper, S, Crowe, J, Chen, F, Koutsavlis, I, Godfrey, A, Arami, S, Drummond, M, Byrne, J, Clark, F, Mead-Harvey, C, Baxter, E J, McMullin, M F & Mead, A J 2023, ' Ruxolitinib versus best available therapy for polycythemia vera intolerant or resistant to hydroxycarbamide in a randomized trial ', Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology . https://doi.org/10.1200/JCO.22.01935
PURPOSE Polycythemia vera (PV) is characterized by JAK/STAT activation, thrombotic/hemorrhagic events, systemic symptoms, and disease transformation. In high-risk PV, ruxolitinib controls blood counts and improves symptoms. PATIENTS AND METHODS MAJIC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd7ce9bbaa9e48083024978d50aea3
https://pure.qub.ac.uk/en/publications/fcda774d-04e8-4597-8a71-76d0585a46e6
https://pure.qub.ac.uk/en/publications/fcda774d-04e8-4597-8a71-76d0585a46e6
Autor:
Claire Harrison, Jyoti Nangalia, Rebecca H. Boucher, Aimee Jackson, Christina Yap, Jennifer O'Sullivan, Sonia Fox, Isaak Ailts, Amylou C Dueck, Holly L. Geyer, Ruben Mesa, William Dunn, Eugene Nadezhdin, Natalia Curto-Garcia, Anna Green, Bridget Wilkins, Jason Coppell, John Laurie, Mamta Garg, Joanne Ewing, Steve Knapper, Josephine Crowe, Ioannis Koutsavlis, Anna L Godfrey, Siamak Arami, Mark W. Drummond, Jennifer Byrne, Fiona J Clark, Carolyn Mead-Harvey, Joanna E Baxter, Mary Frances McMullin, Adam J Mead
Publikováno v:
Blood. 140:1781-1783
Autor:
Zijian Fang, Giuditta Fattori, Thomas McKerrell, Rebecca Boucher, Aimee Jackson, Rachel Fletcher, Dorian Forte, Jose-Ezequiel Martin, Sonia Fox, James Roberts, Rachel Glover, Erica Harris, Hannah Bridges, Luigi Grassi, Alba Rodriguez-Meira, Adam Mead, Steven Knapper, Joanne Ewing, Nauman Butt, Manish Jain, Sebastian Francis, Fiona Clark, Jason Coppell, Mary McMullin, Frances Wadelin, Srinivasan Narayanan, Dragana Milojkovic, Mark Drummond, Mallika Sekhar, Hesham ElDaly, Judy Hirst, Maike Paramor, Elizabeth Baxter, Anna Godfrey, Claire Harrison, Simon Mendez-Ferrer
Current therapies for myeloproliferative neoplasms (MPN) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem and progenitor cells (HSPCs). TAMARIN is a Phas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9f944e8d08dec8b507ac1703d46b5ca
https://doi.org/10.21203/rs.3.rs-2687765/v1
https://doi.org/10.21203/rs.3.rs-2687765/v1
Autor:
Patrick Medd, Dhanapal Vijayavalli, M Wimalachandra, David Tucker, Daniel Bean, Razan El-Bashir, Henry Wood, Robin M. Ireland, Aikaterini Panopoulou, Theodora Vatopoulou, Austin Kulasakeraraj, Thomas Coats, Richard Dobson, Jason Coppell, Michelle Furtado, Joya Pawade
Publikováno v:
EJHaem. 2(2)
Accurate, reproducible diagnoses can be difficult to make in haemato-oncology due to multi-parameter clinical data, complex diagnostic criteria and time-pressured environments. We have designed a decision tree application (DTA) that reflects WHO diag
Autor:
Adam Reuben, Paul Ewings, Andrew Appelboam, Malcolm P Hilton, Jane Vickery, Kara Stevens, Jason Coppell, Andy Barton, Alison N. Jeffery, Wendy Ingram, Richard Body, Brian Wainman
Publikováno v:
Annals of emergency medicine. 77(6)
Study objective Epistaxis is a common emergency department (ED) presentation and, if simple first aid measures fail, can lead to a need for anterior nasal packing. Tranexamic acid is an agent that contributes to blood clot stability. The aim of this
Autor:
Chandan Saha, Holly L. Geyer, Mary Frances McMullin, Christina Yap, Aimee Jackson, Jason Coppell, Robyn M. Scherber, Joanne Ewing, Ruben A. Mesa, Claire N. Harrison, Adam J. Mead, Sonia Fox, Steve Knapper, Amylou C. Dueck, Isaak Ailts, Mark Drummond, Anna L. Godfrey, Carolyn Mead-Harvey, Rebecca H. Boucher
Publikováno v:
Blood. 138:3644-3644
MAJIC is a phase II trial of Ruxolitinib (RUX) vs Best Available Therapy (BAT) in polycythemia vera (PV) patients with resistance/intolerance to Hydroxycarbamide (HC). This analysis involved a primary comparison between the RUX and BAT arms for quali
Autor:
Mary Frances McMullin, Steve Knapper, Ruben A. Mesa, Joanne Ewing, Mark Drummond, Holly L. Geyer, Jason Coppell, Christina Yap, Chandan Saha, Anna L. Godfrey, Robyn M. Scherber, Rebecca H. Boucher, Adam J. Mead, Amylou C. Dueck, Carolyn Mead-Harvey, Claire N. Harrison, Aimee Jackson, Sonia Fox, Isaak Ailts
Publikováno v:
Blood. 138:1507-1507
The myeloproliferative neoplasms (MPN) polycythaemia vera (PV) and essential thrombocythaemia (ET) are associated with significant symptom burden with impaired quality of life (QoL). In the MAJIC study patients refractory/intolerant to hydroxycarbami
Autor:
Nicole A. Carreau, Eva C. Guinan, Paul L. Martin, Jason Coppell, Allen R. Chen, Nancy A. Kernan, Robert J. Soiffer, Tiziano Barbui, Massimo Iacobelli, Carolyn Revta, Dietger Niederwieser, Enric Carreras, Tapani Ruutu, Georgia B. Vogelsang, Sergio Giralt, Amrita Krishnan, Joseph H. Antin, Paul G. Richardson
Publikováno v:
Biology of Blood and Marrow Transplantation. 16(2):157-168
The occurrence of hepatic veno-occlusive disease (VOD) has been reported in up to 60% of patients following stem cell transplantation (SCT), with incidence varying widely between studies depending on the type of transplant, conditioning regimen, and