Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jason Charish"'
Autor:
Xue Fan Wang, Robin Vigouroux, Michal Syonov, Yuriy Baglaenko, Angeliki M. Nikolakopoulou, Dene Ringuette, Horea Rus, Peter V. DiStefano, Suzie Dufour, Alireza P. Shabanzadeh, Seunggi Lee, Bernhard K. Mueller, Jason Charish, Hidekiyo Harada, Jason E. Fish, Joan Wither, Thomas Wälchli, Jean-François Cloutier, Berislav V. Zlokovic, Peter L. Carlen, Philippe P. Monnier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Liver failure causes breakdown of the Blood CNS Barrier (BCB) leading to damages of the Central-Nervous-System (CNS), however the mechanisms whereby the liver influences BCB-integrity remain elusive. One possibility is that the liver secrete
Externí odkaz:
https://doaj.org/article/863ced8c4fb94a3aaaf67d19e08288c8
Autor:
Arthur Aubry, Joel D. Pearson, Jason Charish, Tao Yu, Jeremy M. Sivak, Dimitris P. Xirodimas, Hervé Avet-Loiseau, Jill Corre, Philippe P. Monnier, Rod Bremner
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113711- (2024)
Externí odkaz:
https://doaj.org/article/e123ac04ad4e41e196e403a93c6013ec
Autor:
Arthur Aubry, Joel D. Pearson, Jason Charish, Tao Yu, Jeremy M. Sivak, Dimitris P. Xirodimas, Hervé Avet-Loiseau, Jill Corre, Philippe P. Monnier, Rod Bremner
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112925- (2023)
Summary: The neddylation inhibitor MLN4924/Pevonedistat is in clinical trials for multiple cancers. Efficacy is generally attributed to cullin RING ligase (CRL) inhibition, but the contribution of non-CRL targets is unknown. Here, CRISPR screens map
Externí odkaz:
https://doaj.org/article/98133b06f2024ab69e0484aa57d6b411
Autor:
Alireza P. Shabanzadeh, Jason Charish, Nardos G. Tassew, Nahal Farhani, Jinzhou Feng, Xinjue Qin, Shuzo Sugita, Andrea J. Mothe, Thomas Wälchli, Paulo D. Koeberle, Philippe P. Monnier
Publikováno v:
Neurobiology of Disease, Vol 150, Iss , Pp 105259- (2021)
Neuronal regeneration in the injured central nervous system is hampered by multiple extracellular proteins. These proteins exert their inhibitory action through interactions with receptors that are located in cholesterol rich compartments of the memb
Externí odkaz:
https://doaj.org/article/eea2d8129dd748bf887c1ba3d84a374e
Autor:
Gila Pirzad Jahromi, Alireza Shabanzadeh Pirsaraei, Mina Mokhtari Hashtjini, Seyed Shahabeddin Sadr, Javad Rasouli Vani, Javad Raouf Sarshoori, Jason Charish
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 21, Iss 10, Pp 1004-1012 (2018)
Objective(s): The beneficial outcomes of bone marrow-derived mesenchymal stem cell (BMSC) treatment on functional recovery following stroke has been well established. Furthermore, 5-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors h
Externí odkaz:
https://doaj.org/article/8f76b1e80ed841b2a5174442305ba42e
Autor:
Nardos G. Tassew, Jason Charish, Alireza P. Shabanzadeh, Valbona Luga, Hidekiyo Harada, Nahal Farhani, Philippe D’Onofrio, Brian Choi, Ahmad Ellabban, Philip E.B. Nickerson, Valerie A. Wallace, Paulo D. Koeberle, Jeffrey L. Wrana, Philippe P. Monnier
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 99-111 (2017)
Developing strategies that promote axonal regeneration within the injured CNS is a major therapeutic challenge, as axonal outgrowth is potently inhibited by myelin and the glial scar. Although regeneration can be achieved using the genetic deletion o
Externí odkaz:
https://doaj.org/article/bea754c088164e87b4812073230a8838
Autor:
Angeliki M. Nikolakopoulou, Dene Ringuette, Jason Charish, Joan E. Wither, Alireza P. Shabanzadeh, Seunggi Lee, Horea Rus, Bernhard K. Mueller, Hidekiyo Harada, Jean-François Cloutier, Peter L. Carlen, Philippe P. Monnier, Peter V. DiStefano, Michal Syonov, Thomas Wälchli, Yuriy Baglaenko, Suzie Dufour, Robin J. Vigouroux, Jason E. Fish, Xue Fan Wang, Berislav V. Zlokovic
Liver failure causes blood-brain-barrier (BBB) breakdown leading to central nervous system damage, however the mechanisms whereby the liver influences BBB-integrity remain elusive. One possibility is that the liver secretes an as-yet to be identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3aac60bcbc5442996bf49dabfcda060
https://doi.org/10.21203/rs.3.rs-1028867/v2
https://doi.org/10.21203/rs.3.rs-1028867/v2
Autor:
Jason Charish, Hidekiyo Harada, Xiaoyan Chen, Thomas Wälchli, Cathy L. Barr, Philippe Monnier
The gene KIAA0319-Like ( KIAA0319L ) is thought to confer susceptibility for developmental dyslexia. Dyslexia can be caused by defects in neuronal migration, however, studies done in KIAA0319L knock-out mice did not reveal any neuronal migration phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f15e02d8188e1ad99745dc1f8acc22d2
https://doi.org/10.21203/rs.3.rs-1785961/v1
https://doi.org/10.21203/rs.3.rs-1785961/v1
Autor:
Jean-François Cloutier, Jason Charish, Liliana Attisano, Shuzo Sugita, Rod Bremner, Philippe P. Monnier, Hidekiyo Harada, Nahal Farhani, Xue Fan Wang, Michael Reber, Michael F. Moran
Publikováno v:
Nature Chemical Biology. 15:1035-1042
Until recently, the existence of extracellular kinase activity was questioned. Many proteins of the central nervous system are targeted, but it remains unknown whether, or how, extracellular phosphorylation influences brain development. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd4ef9282f4c0b264a1d69829f8c436
https://doi.org/10.1038/s41589-019-0345-z
https://doi.org/10.1038/s41589-019-0345-z
Autor:
Sami Tabbarah, Erika Tavares, Matteo Di Scipio, Andrew H. Paterson, Jason Charish, Ajoy Vincent, Roberto Mendoza-Londono, Philippe P. Monnier, Elise Heon, Yue Yin, Jason T. Maynes
Publikováno v:
Scientific Reports
Leber congenital amaurosis (LCA), a form of autosomal recessive severe early-onset retinal degeneration, is an important cause of childhood blindness. This may be associated with systemic features or not. Here we identified COG5 compound-heterozygous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763427533406c7d8a39f73619f9eb914
http://europepmc.org/articles/PMC7718911
http://europepmc.org/articles/PMC7718911