Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jason C. Thoen"'
Publikováno v:
Organic Letters. 4:4455-4458
[reaction: see text] The novel amino acid residue (2R,3R,4S)-4-amido-7-guanidino-2,3-dihydroxyheptanoic acid (AGDHE, 3), a constituent of the cyclic depsipeptides callipeltins A and D, and its (2S,3S,4S) diastereomer were synthesized from a protected
Autor:
Chen Mao, Jason C. Thoen, Chun-Lin Chen, Fatih M. Uckun, Xing-Ping Liu, Elise Sudbeck, Hao Chen, Ravi Malaviya
Publikováno v:
Drug Metabolism and Disposition. 30:74-85
Here we report the phase I metabolism of the rationally designed Janus kinase-3 (JAK) inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131; JANEX-1). JANEX-1 was metabolized by the cytochrome P450 enzymes CYP1A1 and CYP1A2 in a reg
Publikováno v:
Tetrahedron Letters. 41:4019-4024
1,4-Didehydronaphthalene, generated by thermolysis of 1,2-diethynylbenzene, reacts with organic hydrogen atom donors via hydrogen atom abstraction. The resulting naphthyl radical undergoes the expected abstraction of a hydrogen atom from a second hyd
Publikováno v:
Tetrahedron Letters. 40:53-56
A new reagent -- 4-nitro-1-H-pyrazole-1-[N, N′-bis(tert-butoxycarbonyl)]car☐amidine -- has been developed to effect the rapid and efficient synthesis of bis(carbamate)-protected guanidines from primary and secondary amines. The reagent is a more
Publikováno v:
The Journal of Organic Chemistry. 63:4604-4610
The cyclic dipeptide cyclo[(R)-His-(R)-Phe] (1) has been known since 1981 to catalyze the enantioselective formation of cyanohydrins from aldehydes and HCN. Although 1 has proved to be very effective in the production of optically active cyanohydrins
Autor:
Mark A. Lipton, Jason C. Thoen
Publikováno v:
Tetrahedron: Asymmetry. 8:3947-3954
The cyclic dipeptide cyclo[( R )-His-( R )-Phe] 1 has been known since 1981 to catalyze the enantioselective formation of cyanohydrins from aldehydes and HCN. Although 1 has proved to be very effective in the production of optically active cyanohydri
Publikováno v:
ChemInform. 27
Autor:
Mark A. Lipton, Jason C. Thoen
Publikováno v:
ChemInform. 29
The cyclic dipeptide cyclo[( R )-His-( R )-Phe] 1 has been known since 1981 to catalyze the enantioselective formation of cyanohydrins from aldehydes and HCN. Although 1 has proved to be very effective in the production of optically active cyanohydri
Publikováno v:
ChemInform. 31
1,4-Didehydronaphthalene, generated by thermolysis of 1,2-diethynylbenzene, reacts with organic hydrogen atom donors via hydrogen atom abstraction. The resulting naphthyl radical undergoes the expected abstraction of a hydrogen atom from a second hyd
Publikováno v:
The Journal of Organic Chemistry. 60:8407-8409