Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jason C. Choi"'
Autor:
Jasmine Saunders, Kunal Sikder, Elizabeth Phillips, Anurag Ishwar, David Mothy, Kenneth B. Margulies, Jason C. Choi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6155 (2023)
Mediator 25 (Med25) is a member of the mediator complex that relays signals from transcription factors to the RNA polymerase II machinery. Multiple transcription factors, particularly those involved in lipid metabolism, utilize the mediator complex,
Externí odkaz:
https://doaj.org/article/8c9376d479bb4a72bfd129a93b313b0f
Abstract 730: Celltype-Specific Functions in Dilated Cardiomyopathy Caused by the LMNA Gene Mutation
Autor:
Elizabeth Phillips, Kunal Sikder, Kenneth B. Margulies, Jason C. Choi, Zhijiu Zhong, Nadan Wang
Publikováno v:
Circulation Research. 125
Mutations in the LMNA gene, encoding lamins A and C (lamin A/C) cause a diverse group of human diseases termed laminopathies. The most prevalent laminopathy is dilated cardiomyopathy (herein referred to as LMNA cardiomyopathy) characterized by variab
Autor:
Howard J. Worman, Jason C. Choi, Fusako Sera, Elizabeth Phillips, Wei Wu, Shunichi Homma, Robin Plevin
Publikováno v:
Human molecular genetics. 27(13)
Mutations in the lamin A/C gene (LMNA) encoding the nuclear intermediate filament proteins lamins A and C cause a group of tissue-selective diseases, the most common of which is dilated cardiomyopathy (herein referred to as LMNA cardiomyopathy) with
Autor:
Uma Shastri, Paul Hobeika, Ali Shariat, Ashton Frulla, Kwesi Kwofie, Daquan Xu, Emine Aysu Salviz, Junping Chen, Sanford Littwin, Emily Lin, Jason C. Choi, Admir Hadzic
Publikováno v:
Anesthesia & Analgesia. 117:1485-1492
We performed this randomized trial to compare the recovery profile of patients receiving single injection (SISB) and continuous interscalene brachial plexus block (CISB) or general anesthesia (GA) for arthroscopic rotator cuff repair surgery through
Publikováno v:
Current Opinion in Anaesthesiology. 26:467-474
Purpose of review There has been an increasing use of peripheral nerve blocks (PNBs) in ambulatory surgery. Several recent reports have contributed to our understanding of the optimal PNB technique for specific surgical procedures in this setting. In
Publikováno v:
Journal of Biological Chemistry. 287:40513-40524
Mutations in LMNA gene cause cardiomyopathy, for which mechanistic insights are lacking.Dusp4 expression is enhanced in hearts with LMNA cardiomyopathy, and its overexpression in mice causes it by activating AKT-mTOR signaling that impairs autophagy.
Autor:
Gregg G. Gundersen, Howard J. Worman, Cecilia Östlund, Yuexia Wang, Theresa C Swayne, Jason C. Choi
Publikováno v:
Nucleus. 3:452-462
Mutations in the lamin A/C gene that cause Hutchinson-Gilford progeria syndrome lead to expression of a truncated, permanently farnesylated prelamin A variant called progerin. Blocking farnesylation leads to an improvement in the abnormal nuclear mor
Autor:
Howard J. Worman, Edgar R. Gomes, Gregg G. Gundersen, Eric S. Folker, Jason C. Choi, Cecilia Östlund
Publikováno v:
Journal of Cell Science. 122:4099-4108
The linker of nucleoskeleton and cytoskeleton (LINC) complex is situated in the nuclear envelope and forms a connection between the lamina and cytoskeletal elements. Sun1, Sun2 and nesprin-2 are important components of the LINC complex. We expressed
Autor:
Ann Ho, Yan Zhou, Stefan D. Schlussman, Ji-Sheng Han, Jason C. Choi, Cai-Lian Cui, Mary Jeanne Kreek
Publikováno v:
Neuroscience. 153:1225-1234
Recent evidence suggests an important role for hypothalamic orexins/hypocretins in modulation of drug reward and addiction-like behaviors in rodents. Our recent study has shown that the aversive state of arousal during acute morphine withdrawal is as
Autor:
Sharon S. Evans, Bonnie L. Hylander, Yan Xu, Arindam Sen, Elizabeth A. Repasky, Jason C. Choi, William G. Kraybill
Publikováno v:
International Journal of Hyperthermia. 23:513-527
Two major questions were addressed: (1) Can fever-range whole body hyperthermia (FR-WBH) affect the number of perfused tumor blood vessels? (2) Can pre-treatment with FR-WBH improve accumulation or anti-tumor efficacy of doxorubicin or DOXIL (liposom