Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jason C Tanny"'
Autor:
Sarah MacKinnon, Viviane Pagé, Jennifer J Chen, Ali Shariat-Panahi, Ryan D Martin, Terence E Hébert, Jason C Tanny
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1010492 (2023)
Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability. Paradoxically, transcription of heterochromatic sequences is required for establ
Externí odkaz:
https://doaj.org/article/dbd12551f7714f75a90c65fa64656856
Autor:
Jean Mbogning, Stephen Nagy, Viviane Pagé, Beate Schwer, Stewart Shuman, Robert P Fisher, Jason C Tanny
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004029 (2013)
Cyclin-dependent kinase 9 (Cdk9) promotes elongation by RNA polymerase II (RNAPII), mRNA processing, and co-transcriptional histone modification. Cdk9 phosphorylates multiple targets, including the conserved RNAPII elongation factor Spt5 and RNAPII i
Externí odkaz:
https://doaj.org/article/1a30c2609ea648ff8662ebc16ea2b4b4
Autor:
Miriam Sansó, Karen M Lee, Laia Viladevall, Pierre-Étienne Jacques, Viviane Pagé, Stephen Nagy, Ariane Racine, Courtney V St Amour, Chao Zhang, Kevan M Shokat, Beate Schwer, François Robert, Robert P Fisher, Jason C Tanny
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002822 (2012)
Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation are not understood.
Externí odkaz:
https://doaj.org/article/ac50f2f8315a444bae83530986674001
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Histone ubiquitylation is a critical part of both active and repressed transcriptional states, and lies at the heart of DNA damage repair signaling. The histone residues targeted for ubiquitylation are often highly conserved through evolution, and ex
Externí odkaz:
https://doaj.org/article/2b5d21594737430b9c8ebb7cc21c959e
Autor:
Shahriar M. Khan, Ryan D. Martin, Andrew Bayne, Darlaine Pétrin, Kyla Bourque, Jace Jones-Tabah, Celia Bouazza, Jacob Blaney, Jenny Lau, Kimberly Martins-Cannavino, Sarah Gora, Andy Zhang, Sarah MacKinnon, Phan Trieu, Paul B.S. Clarke, Jean-François Trempe, Jason C. Tanny, Terence E. Hébert
Publikováno v:
J Biol Chem
Gβγ subunits mediate many different signaling processes in various compartments of the cell, including the nucleus. To gain insight into the functions of nuclear Gβγ signaling, we investigated the functional role of Gβγ signaling in the regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0c1bfa2516edf92669128fd1b416ba
https://europepmc.org/articles/PMC10060754/
https://europepmc.org/articles/PMC10060754/
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3354 (2020)
Inhibitors targeting the general RNA polymerase II (RNAPII) transcription machinery are candidate therapeutics in cancer and other complex diseases. Here, we review the molecular targets and mechanisms of action of these compounds, framing them withi
Externí odkaz:
https://doaj.org/article/d730a48df81d47309df49b9a5340fa6e
Publikováno v:
Molecular Pharmacology. 100:526-539
Genetically encoded biosensors can be used to track signaling events in living cells by measuring changes in fluorescence emitted by one or more fluorescent proteins. Here, we describe the use of genetically encoded biosensors based on Forster resona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6ec8e1b002c456be140ce59d86f75c
https://doi.org/10.1124/molpharm.121.000290
https://doi.org/10.1124/molpharm.121.000290
Autor:
Mohammad Amraei, Monique Lagacé, Jean-Michel Longpré, Viktoriya Lukasheva, Ryan D. Martin, Christian Le Gouill, Graciela Piñeyro, Dominic Devost, Yuji Shinjo, Stéphane A. Laporte, Junken Aoki, Billy Breton, Mireille Hogue, Michel Bouvier, Asuka Inoue, Yoon Namkung, Terence E. Hébert, Jason C. Tanny
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
A comprehensive understanding of signalling downstream of GPCRs requires a broad approach to capture novel signalling modalities in addition to established pathways. Here, using an array of sixteen validated BRET-based biosensors, we analyzed the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1089637a764ec4169b322941b3c13d
http://link.springer.com/article/10.1038/s41598-020-65636-3
http://link.springer.com/article/10.1038/s41598-020-65636-3
Autor:
Alain Fournier, Bruce G. Allen, Tuan Anh Hoang, Terence E. Hébert, Ryan D. Martin, Alfonso Carotenuto, Juliana C. C. Dallagnol, Myriam Létourneau, Hassan Nassour, David Chatenet, Étienne Billard, Jason C. Tanny, Ettore Novellino
Publikováno v:
The Journal of Biological Chemistry
Over the last decade, the urotensinergic system, composed of one G protein-coupled receptor and two endogenous ligands, has garnered significant attention as a promising new target for the treatment of various cardiovascular diseases. Indeed, this sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fe3abca6a81eb53384d871fe901993
http://europepmc.org/articles/PMC8424217
http://europepmc.org/articles/PMC8424217
Autor:
Paul Bs Clarke, Jace Jones-Tabah, Ryan D. Martin, Terence E. Hébert, Jennifer J. Chen, Jason C. Tanny
The activity of striatal medium-spiny projection neurons is regulated by dopamine acting principally at D1 and D2 dopamine receptors. The dopamine D1 receptor (D1R) is a Gαs/olf-coupled GPCR which activates a cAMP/PKA/DARPP-32 signalling cascade tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d06c82169a12bb3a9fa5b12b3fb8686b
https://doi.org/10.1101/2021.07.01.450754
https://doi.org/10.1101/2021.07.01.450754