Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Jason C O'Connor"'
Publikováno v:
JMIR Research Protocols, Vol 12, p e52199 (2023)
BackgroundFatigue is a strong predictor of negative health outcomes in older adults. Kynurenine, a metabolite of tryptophan, is strongly associated with fatigue. Reductions in fatigue are observed with exercise; however, exercise training does not co
Externí odkaz:
https://doaj.org/article/dc70824813c1468c900a0d8b4eaa9136
Autor:
Dianelys Gonzalez-Pena, Scott E Nixon, Jason C O'Connor, Bruce R Southey, Marcus A Lawson, Robert H McCusker, Tania Borras, Debbie Machuca, Alvaro G Hernandez, Robert Dantzer, Keith W Kelley, Sandra L Rodriguez-Zas
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150858 (2016)
Depression symptoms following immune response to a challenge have been reported after the recovery from sickness. A RNA-Seq study of the dysregulation of the microglia transcriptome in a model of inflammation-associated depressive behavior was undert
Externí odkaz:
https://doaj.org/article/5181b5e3b1f74903ad63b2e1dcade39d
Autor:
Jennifer M Parrott, Jason C O'Connor
Publikováno v:
Frontiers in Psychiatry, Vol 6 (2015)
Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders. The kynurenine pathway consists of two functionally distinct branches that gen
Externí odkaz:
https://doaj.org/article/5654e4a1752a43da939ebb463bf65b1f
Autor:
Xiuhua Li, Laney Redus, Cang Chen, Paul A Martinez, Randy Strong, Senlin Li, Jason C O'Connor
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71341 (2013)
Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by progressive loss of dopamine neurons, leading to loss of motor coordination. However, PD is associated with a high rate of non-motor neuropsychiatric comorbities that
Externí odkaz:
https://doaj.org/article/658bb09489a941fa9832a5fa186b1cc4
Autor:
Christopher B Guest, Matthew E Hartman, Jason C O'Connor, Kenneth S Chakour, Ali A Sovari, Gregory G Freund
Publikováno v:
PLoS ONE, Vol 2, Iss 6, p e511 (2007)
Type 2 diabetes (T2D) is associated with accelerated atherosclerosis, which accounts for approximately 75% of all diabetes-related deaths. Here we investigate the link between diabetes and macrophage cholesteryl ester accumulation. When diabetic (db/
Externí odkaz:
https://doaj.org/article/3850c5e0fc0142c48ef03eaa8dd687db
Autor:
Cang Chen, Michael J. Guderyon, Yang Li, Guo Ge, Anindita Bhattacharjee, Cori Ballard, Zhixu He, Eliezer Masliah, Robert A. Clark, Jason C. O’Connor, Senlin Li
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 83-98 (2020)
Glial cell-line-derived neurotrophic factor (GDNF) is a potent neuroprotective agent in cellular and animal models of Parkinson’s disease (PD). However, CNS delivery of GDNF in clinical trials has proven challenging due to blood-brain barrier (BBB)
Externí odkaz:
https://doaj.org/article/5c056ea128414a0eaa1386177f078e69
Autor:
Danielle Santana-Coelho, Donna Layne-Colon, Roslyn Valdespino, Corinna C. Ross, Suzette D. Tardif, Jason C. O'Connor
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Understanding the mechanism(s) by which maternal immune activation (MIA) during gestation may disrupt neurodevelopment and increase the susceptibility for disorders such as autism spectrum disorder (ASD) or schizophrenia is a critical step in the dev
Externí odkaz:
https://doaj.org/article/f587fc139c254379a88eb1c44bda4041
Autor:
Ronna N. Robbins, Jessica L. Kelleher, Priyathama Vellanki, Jason C. O’Connor, Jennifer S. Mascaro, Joe R. Nocera, Monica C. Serra
Publikováno v:
Journal of Functional Morphology and Kinesiology, Vol 7, Iss 2, p 45 (2022)
This pilot examines whether resistance training (RT) can induce changes in kynurenine (KYN) metabolism, which may contribute to improved physical function in breast cancer survivors (BCSs). Thirty-six BCSs (63.2 ± 1.1 years) underwent assessments of
Externí odkaz:
https://doaj.org/article/165b722e65d740b79b77ebe6d0cb0101
Publikováno v:
Archives of Physical Medicine and Rehabilitation. 103:2077-2084
To investigate the effect of aerobic exercise vs control (stretching/balance) on inflammatory and oxidative stress biomarkers in stroke survivors and whether these changes are associated with improvements in physical and metabolic health.Randomized c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aded907ac3225d651fae41b1a44095b
https://doi.org/10.1016/j.apmr.2022.06.011
https://doi.org/10.1016/j.apmr.2022.06.011
Publikováno v:
Cells, Vol 10, Iss 6, p 1548 (2021)
Diseases of the central nervous system (CNS) remain a significant health, social and economic problem around the globe. The development of therapeutic strategies for CNS conditions has suffered due to a poor understanding of the underlying pathologie
Externí odkaz:
https://doaj.org/article/736609b939384dfca6053e946d465997