Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Jason C Cole"'
Publikováno v:
Kidney Medicine, Vol 5, Iss 2, Pp 100587- (2023)
Rationale & Objective: There is limited published research on how autosomal dominant polycystic kidney disease (ADPKD) impacts caregivers. This study explored how caregivers of individuals with ADPKD perceive the burdens placed on them by the disease
Externí odkaz:
https://doaj.org/article/a7021933a80a454d8cdd11cb83033419
Autor:
Dorothee Oberdhan, Franz Schaefer, Jason C. Cole, Andrew C. Palsgrove, Ann Dandurand, Lisa Guay-Woodford
Publikováno v:
Kidney Medicine, Vol 4, Iss 3, Pp 100415- (2022)
Rationale & Objective: Little is known about symptoms and disease impacts in adolescents with autosomal dominant polycystic kidney disease (ADPKD). The objective of the study was to explore these issues from the adolescent patient’s perspective. St
Externí odkaz:
https://doaj.org/article/ea3fc631ef394a19b277bb08cd289102
Publikováno v:
Oncology and Therapy, Vol 8, Iss 2, Pp 299-310 (2020)
Abstract Introduction There are no validated patient-reported outcome (PRO) instruments for Epstein–Barr virus-driven post-transplant lymphoproliferative disease (EBV+ PTLD). The aim of this study was to assess the content applicability for three f
Externí odkaz:
https://doaj.org/article/a3f93ec3b29e41e18952e518600d4608
Autor:
Andreas Tosstorff, Markus G. Rudolph, Jason C. Cole, Michael Reutlinger, Christian Kramer, Hervé Schaffhauser, Agnès Nilly, Alexander Flohr, Bernd Kuhn
Publikováno v:
Journal of Computer-Aided Molecular Design. 36:753-765
We release a new, high quality data set of 1162 PDE10A inhibitors with experimentally determined binding affinities together with 77 PDE10A X-ray co-crystal structures from a Roche legacy project. This data set is used to compare the performance of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffb943fe62ae8f7b151926cb2e8bdee
https://doi.org/10.1007/s10822-022-00478-x
https://doi.org/10.1007/s10822-022-00478-x
Publikováno v:
Structural Dynamics, Vol 6, Iss 5, Pp 054301-054301-6 (2019)
The Cambridge Structural Database (CSD) is the world's largest and most comprehensive collection of organic, organometallic, and metal-organic crystal structure information. Analyses using the data have wide impact across the chemical sciences in all
Externí odkaz:
https://doaj.org/article/f5975189adde4a5da12145008d2617f3
Autor:
Lawson T. Glasby, Kristian Gubsch, Rosalee Bence, Rama Oktavian, Kesler Isoko, Seyed Mohamad Moosavi, Joan L. Cordiner, Jason C. Cole, Peyman Z. Moghadam
Publikováno v:
Chemistry of Materials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::002dc3f8d4b80ff1d8919bbdb40e326e
https://doi.org/10.1021/acs.chemmater.3c00788
https://doi.org/10.1021/acs.chemmater.3c00788
Publikováno v:
Neurology and Therapy. 11:725-739
Fatigue is one of the most common and debilitating symptoms of multiple sclerosis (MS) but is challenging to assess and has not been comprehensively characterized in patients with progressive MS. This study aimed to (1) obtain qualitative evidence fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804e047e27f9f5791582766ec2cef39d
https://doi.org/10.1007/s40120-022-00337-9
https://doi.org/10.1007/s40120-022-00337-9
Publikováno v:
Wright, S E, Cole, J C & Cruz-cabeza, A J 2021, ' Conformational Change in Molecular Crystals: Impact of Solvate Formation and Importance of Conformational Free Energies ', Crystal Growth & Design . https://doi.org/10.1021/acs.cgd.1c00833
Changes in molecular conformation and its relationship with crystal polymorphism have been well documented in previous work. To the best of our knowledge, however, the effect of solvate formation on molecular conformation has never been explored. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774764ce66f7f71e9d41107f78998a20
https://doi.org/10.1021/acs.cgd.1c00833
https://doi.org/10.1021/acs.cgd.1c00833
Publikováno v:
ChemMedChem. 16:3428-3438
The previously introduced ratio of frequencies (RF ) framework provides statistically sound information on the relative interaction preferences of atoms in crystal structures. By applying the methodology to protein-ligand complexes, we can investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4eb37f55eb6981630f5bc8572f80657
https://doi.org/10.1002/cmdc.202100387
https://doi.org/10.1002/cmdc.202100387
Autor:
Mark P. Walsh, James A. Barclay, Callum S. Begg, Jinyi Xuan, Natalie T. Johnson, Jason C. Cole, Matthew O. Kitching
Publikováno v:
JACS Au, 2022, Vol.2(10), pp.2235-2250 [Peer Reviewed Journal]
Conglomerate crystallization is the spontaneous generation of individually enantioenriched crystals from a nonenantioenriched material. This behavior is responsible for spontaneous resolution and the discovery of molecular chirality by Pasteur. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905d6a71c5bf7cf27018a224002799f1
https://pubmed.ncbi.nlm.nih.gov/36311827
https://pubmed.ncbi.nlm.nih.gov/36311827