Zobrazeno 1 - 10
of 397
pro vyhledávání: '"Jason C, Kovacic"'
Autor:
Danit G. Saks, Beata Bajorek, Vibeke S. Catts, Adam C. Bentvelzen, Jiyang Jiang, Wei Wen, Karen A. Mather, Anbupalam Thalamuthu, Jessie Huang-Lung, Lisa Nivison-Smith, Lyn R. Griffiths, Robert A. Smith, Adrienne Sexton, Paul James, Tharusha Jayasena, Anne Poljak, Gurpreet K. Hansra, Satoshi Hosoki, Ashley Park, Claudia M. Hillenbrand, Peter van Wijngaarden, Russell J. Chander, Sam Humphrey, Rory Chen, Nicole A. Kochan, Tessa J. Helman, Christopher Levi, Amy Brodtmann, Michael J. O'Sullivan, Romesh Markus, Ken Butcher, Mark Parsons, Jason C. Kovacic, Perminder S. Sachdev
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100225- (2024)
Introduction: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic condition with a broad phenotypic presentation. This study aims to establish the first Australian cohort of individua
Externí odkaz:
https://doaj.org/article/526edede2535460a845731b93a501cc1
Autor:
Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100465- (2024)
Summary: Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms of these risk loci du
Externí odkaz:
https://doaj.org/article/edb54c8409764f119fe134388ec9ee15
Autor:
Radoslav Savić, Jialiang Yang, Simon Koplev, Mahru C. An, Priyanka L. Patel, Robert N. O’Brien, Brittany N. Dubose, Tetyana Dodatko, Eduard Rogatsky, Katyayani Sukhavasi, Raili Ermel, Arno Ruusalepp, Sander M. Houten, Jason C. Kovacic, Andrew F. Stewart, Christopher B. Yohn, Eric E. Schadt, Remi-Martin Laberge, Johan L.M. Björkegren, Zhidong Tu, Carmen Argmann
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113371- (2023)
Summary: Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we integrate the transcripto
Externí odkaz:
https://doaj.org/article/1c20f6d542d54b86acc9526737df22b2
Autor:
Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. Sheffield, Clint L. Miller
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113380- (2023)
Summary: Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the arterial wall. CAD progression involves complex interactions and phenotypic plasticity among vascular and immune cell lineages. Single-cell RNA-seq (sc
Externí odkaz:
https://doaj.org/article/f36322cc9dc74a4986bc713522f0f6e4
Autor:
Mayooran Namasivayam, Thomas Meredith, David W. M. Muller, David A. Roy, Andrew K. Roy, Jason C. Kovacic, Christopher S. Hayward, Michael P. Feneley
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundModerate severity aortic stenosis (AS) is poorly understood, is associated with subclinical myocardial dysfunction, and can lead to adverse outcome rates that are comparable to severe AS. Factors associated with progressive myocardial dysfu
Externí odkaz:
https://doaj.org/article/5ed9570774c24d0aa7618f1de6c4585f
Autor:
Monique Bax, Valentin Romanov, Keerat Junday, Eleni Giannoulatou, Boris Martinac, Jason C. Kovacic, Renjing Liu, Siiri E. Iismaa, Robert M. Graham
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Arterial dissections, which involve an abrupt tear in the wall of a major artery resulting in the intramural accumulation of blood, are a family of catastrophic disorders causing major, potentially fatal sequelae. Involving diverse vascular beds, inc
Externí odkaz:
https://doaj.org/article/e4b610f8950143d3b877b17fd6679115
Autor:
Adrien Georges, Min-Lee Yang, Takiy-Eddine Berrandou, Mark K. Bakker, Ozan Dikilitas, Soto Romuald Kiando, Lijiang Ma, Benjamin A. Satterfield, Sebanti Sengupta, Mengyao Yu, Jean-François Deleuze, Delia Dupré, Kristina L. Hunker, Sergiy Kyryachenko, Lu Liu, Ines Sayoud-Sadeg, Laurence Amar, Chad M. Brummett, Dawn M. Coleman, Valentina d’Escamard, Peter de Leeuw, Natalia Fendrikova-Mahlay, Daniella Kadian-Dodov, Jun Z. Li, Aurélien Lorthioir, Marco Pappaccogli, Aleksander Prejbisz, Witold Smigielski, James C. Stanley, Matthew Zawistowski, Xiang Zhou, Sebastian Zöllner, FEIRI investigators, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group, MEGASTROKE, Philippe Amouyel, Marc L. De Buyzere, Stéphanie Debette, Piotr Dobrowolski, Wojciech Drygas, Heather L. Gornik, Jeffrey W. Olin, Jerzy Piwonski, Ernst R. Rietzschel, Ynte M. Ruigrok, Miikka Vikkula, Ewa Warchol Celinska, Andrzej Januszewicz, Iftikhar J. Kullo, Michel Azizi, Xavier Jeunemaitre, Alexandre Persu, Jason C. Kovacic, Santhi K. Ganesh, Nabila Bouatia-Naji
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Fibromuscular dysplasia is a cardiovascular disease affecting mostly women with a mostly unknown genetic basis. Here the authors have performed a genome-wide association meta-analysis of Fibromuscular dysplasia to identify genetic loci, some of which
Externí odkaz:
https://doaj.org/article/1ca76cab0eb244289d31e35f5458c7b3
Autor:
Lijiang Ma, Nicole S Bryce, Adam W Turner, Antonio F Di Narzo, Karishma Rahman, Yang Xu, Raili Ermel, Katyayani Sukhavasi, Valentina d'Escamard, Nirupama Chandel, Bhargavi V'Gangula, Kathryn Wolhuter, Daniella Kadian-Dodov, Oscar Franzen, Arno Ruusalepp, Ke Hao, Clint L Miller, Johan L M Björkegren, Jason C Kovacic
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010261 (2022)
Genome wide association studies (GWAS) have identified thousands of single nucleotide polymorphisms (SNPs) associated with the risk of common disorders. However, since the large majority of these risk SNPs reside outside gene-coding regions, GWAS gen
Externí odkaz:
https://doaj.org/article/8f50972152a349d08f4369b9b5980542
Autor:
Ariella T. Cohain, William T. Barrington, Daniel M. Jordan, Noam D. Beckmann, Carmen A. Argmann, Sander M. Houten, Alexander W. Charney, Raili Ermel, Katyayani Sukhavasi, Oscar Franzen, Simon Koplev, Carl Whatling, Gillian M. Belbin, Jialiang Yang, Ke Hao, Eimear E. Kenny, Zhidong Tu, Jun Zhu, Li-Ming Gan, Ron Do, Chiara Giannarelli, Jason C. Kovacic, Arno Ruusalepp, Aldons J. Lusis, Johan L. M. Bjorkegren, Eric E. Schadt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucos
Externí odkaz:
https://doaj.org/article/0c2afd1828064aad921b2b15f3e5c1e2
Autor:
Sabine Bauer, Jana Eigenmann, Yuqi Zhao, Julia Fleig, Johann S. Hawe, Calvin Pan, Dario Bongiovanni, Simon Wengert, Angela Ma, Aldons J. Lusis, Jason C. Kovacic, Johan L. M. Björkegren, Lars Maegdefessel, Heribert Schunkert, Moritz von Scheidt
Publikováno v:
Metabolites, Vol 12, Iss 9, p 840 (2022)
Coronary artery disease (CAD) is a complex, multifactorial disease caused, in particular, by inflammation and cholesterol metabolism. At the molecular level, the role of tissue-specific signaling pathways leading to CAD is still largely unexplored. T
Externí odkaz:
https://doaj.org/article/efe6562806804c91a3b74dc0b85090ca