Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jason Brunton"'
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Francisella tularensis is a Gram-negative, facultative, intracellular bacterial pathogen and one of the most virulent organisms known. A hallmark of F. tularensis pathogenesis is the bacterium’s ability to replicate to high densities withi
Externí odkaz:
https://doaj.org/article/37165435e81943a0b6fd0a6c6f202536
Publikováno v:
eLife, Vol 5 (2016)
Macrophages are myeloid-derived phagocytic cells and one of the first immune cell types to respond to microbial infections. However, a number of bacterial pathogens are resistant to the antimicrobial activities of macrophages and can grow within thes
Externí odkaz:
https://doaj.org/article/c96ceebd512c49aa85f58a9543bafd6a
Autor:
Shaun Steele, Jason Brunton, Benjamin Ziehr, Sharon Taft-Benz, Nathaniel Moorman, Thomas Kawula
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003562 (2013)
Francisella tularensis is a highly virulent intracellular pathogen that invades and replicates within numerous host cell types including macrophages, hepatocytes and pneumocytes. By 24 hours post invasion, F. tularensis replicates up to 1000-fold in
Externí odkaz:
https://doaj.org/article/352391c67a1a42378612f506c70a1c2a
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003552 (2013)
Externí odkaz:
https://doaj.org/article/27a5191ce98244c681eaa84b23a3a7f9
Publikováno v:
mBio
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e01471-18 (2018)
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e01471-18 (2018)
The widespread onset of antibiotic resistance prioritizes the need for novel antimicrobial strategies to prevent the spread of disease. With its low infectious dose, broad host range, and high rate of mortality, F. tularensis poses a severe risk to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cb036dac8a01ccc4be1841576c0869
https://pubmed.ncbi.nlm.nih.gov/30459188
https://pubmed.ncbi.nlm.nih.gov/30459188
Autor:
Shaun Steele, Anthony R. Richardson, James R. Fuller, Cheryl N. Miller, Jason Brunton, Eric D. LoVullo, Thomas H. Kawula, Sharon Taft-Benz, Todd M. Kijek
Publikováno v:
Journal of Bacteriology. 195:965-976
Pantothenate, commonly referred to as vitamin B(5), is an essential molecule in the metabolism of living organisms and forms the core of coenzyme A. Unlike humans, some bacteria and plants are capable of de novo biosynthesis of pantothenate, making t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4009b3ad6979dfbb02895d40589d73b6
https://doi.org/10.1128/jb.01740-12
https://doi.org/10.1128/jb.01740-12
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Macrophages are myeloid-derived phagocytic cells and one of the first immune cell types to respond to microbial infections. However, a number of bacterial pathogens are resistant to the antimicrobial activities of macrophages and can grow within thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44363114054a837becfbd35f07dda06
https://pubmed.ncbi.nlm.nih.gov/26919282
https://pubmed.ncbi.nlm.nih.gov/26919282
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 5 (2015)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
Following entry into host cells intracellular pathogens must simultaneously evade innate host defense mechanisms and acquire energy and anabolic substrates from the nutrient-limited intracellular environment. Most of the potential intracellular nutri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8bdbbc7cce9d3dabb834c18ee76694
http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00051/full
http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00051/full
Autor:
Sharon Taft-Benz, Cheryl N. Miller, Thomas H. Kawula, Jason Brunton, E. Lovullo, Shaun Steele
Francisella tularensis is a highly virulent Gram-negative intracellular pathogen capable of infecting a vast diversity of hosts, ranging from amoebae to humans. A hallmark of F. tularensis virulence is its ability to quickly grow to high densities wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2f0e4da266ea96d1e6db3e9d8eb10c
