Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jason Boggs"'
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Fig. S2 - PDF file 365K, Tankyrase and receptor tyrosine kinase pathway inhibitor effects on CRC cell line and intestinal organoid growth.(A) Percentage of cells for the indicated three cell lines showing phospho-histone H3 staining as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3671cf9cc3417dafef5febd7161cb4
https://doi.org/10.1158/0008-5472.22397417
https://doi.org/10.1158/0008-5472.22397417
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Data PDF file 168K, Supplementary Materials and Methods; Supplementary Figure and Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21399da823f5abc615038bcca3202ada
https://doi.org/10.1158/0008-5472.22397423.v1
https://doi.org/10.1158/0008-5472.22397423.v1
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Table S1 - PDF file 18K, Tankyrase inhibitor potency and selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3068d4183ba918387a3758670ec549d3
https://doi.org/10.1158/0008-5472.22397405.v1
https://doi.org/10.1158/0008-5472.22397405.v1
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
PDF file - 58K, G007-LK effects on tumor growth and mouse body weight in xenograft efficacy studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01837cac0b67d9a086e98b54d7a62b5a
https://doi.org/10.1158/0008-5472.22397408.v1
https://doi.org/10.1158/0008-5472.22397408.v1
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Fig. S4 - PDF file 724K, G007-LK effects in mice at toxic doses.(A) Higher magnification view, compared to Fig. 6C, of the ileum (H&E stained section) showing villous blunting (between arrow and arrowhead), fusion, and neutrophilic infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db0130943d23644785337b90d0c68c5
https://doi.org/10.1158/0008-5472.22397411.v1
https://doi.org/10.1158/0008-5472.22397411.v1
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Fig. S1 - PDF file 341K, Tankyrase inhibitor effects on APC-wildtype and -mutant cell lines. (A) Dose-response curves of three tankyrase inhibitors for TOPbrite Wnt/�-catenin luciferase reporter activity and cell viability (upper grap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37538160cda45c2ef4fe016626d27750
https://doi.org/10.1158/0008-5472.22397420
https://doi.org/10.1158/0008-5472.22397420
Autor:
Mike Costa, Stefan Krauss, Daniel D. Holsworth, Paul Polakis, Mark Merchant, Dolores Diaz, Edna Choo, Vladimir Korinek, Ondrej Machon, Ron Firestein, Melissa Schutten, Amy Sambrone, Steven Magnuson, Robert A. Blake, Jason Boggs, Jo Waaler, Marinella Callow, Emily Chan, Ted Lau
Supplementary Fig. S3 - PDF file 1785K,Pharmacokinetic and anti-tumor efficacy properties of tankyrase inhibitors. (A) Pharmacokinetic parameters for G007-LK and G244-LM determined from the mouse studies described in Fig. 4A. (B) G007-LK exposure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cf5bbfceadd629955c80bd540983d4
https://doi.org/10.1158/0008-5472.22397414.v1
https://doi.org/10.1158/0008-5472.22397414.v1
Autor:
S. Cyrus Khojasteh, Shuguang Ma, Edna F. Choo, Cornelis E. C. A. Hop, Qin Yue, Justin Ly, Ryan H. Takahashi, Jason Boggs, Andrew McClory, Heasook Kim-Kang, Alec Fettes, Yuzhong Deng, Yijun Yi
Publikováno v:
Xenobiotica. 47:50-65
1. The absorption, metabolism and excretion of cobimetinib, an allosteric inhibitor of MEK1/2, was characterized in mass balance studies following single oral administration of radiolabeled (14C) cobimetinib to Sprague–Dawley rats (30 mg/kg) and Be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d933d347fb26d4ec3bb5b1fb81d994
https://doi.org/10.3109/00498254.2016.1157645
https://doi.org/10.3109/00498254.2016.1157645
Autor:
Dolores Diaz, Eric Harstad, Mark Merchant, Ted Lau, Paula Katavolos, Amy Sambrone, Melissa Schutten, Trung Nguyen, David Kan, Jason Boggs, Mike Costa, Yu Zhong
Publikováno v:
Toxicologic Pathology. 44:267-278
Activated Wnt/β-catenin signaling is frequently associated with colorectal cancer. Wnt inhibitors, including tankyrase inhibitors, are being explored as potential anticancer agents. Wnt signaling is also critical for intestinal tissue homeostasis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd8f8f835a627de646f5df3c8b34a02
https://doi.org/10.1177/0192623315621192
https://doi.org/10.1177/0192623315621192
Autor:
Joy Drobnick, Kevin X. Chen, Amy Sambrone, Stephen Schmidt, Lan Wang, Tao Wang, Ping Wu, Jim Nonomiya, Jinhua Chen, Seth F. Harris, Stacey Yeung, Chudi Ndubaku, Zijin Xu, Stephen E. Gould, Huifen Chen, Terry Crawford, Weilan Ye, Tanya Smyczek, Jason Boggs, Rajiv Jesudason, Erin McNamara, Philip Vitorino, Ding Charles Z, Lesley J. Murray
Publikováno v:
ACS Medicinal Chemistry Letters. 6:913-918
Diverse biological roles for mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) have necessitated the identification of potent inhibitors in order to study its function in various disease contexts. In particular, compounds that can be u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4691b6776a7f46441928aa91ff58247f
https://doi.org/10.1021/acsmedchemlett.5b00174
https://doi.org/10.1021/acsmedchemlett.5b00174