Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jason B. Papke"'
Autor:
Kevin Y. Yin, Juan Mo, Lu Q. Le, Zhiguo Chen, Corina Anastasaki, Jason B. Papke, Tracey Shipman, David H. Gutmann
Publikováno v:
J Clin Invest
Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome caused by NF1 gene mutation, in which affected patients develop Schwann cell lineage peripheral nerve sheath tumors (neurofibromas). To investigate human neurofibroma pathogenes
Autor:
Olivia Cobb, Stephanie M. Morris, Kelly Hartigan, Jason B. Papke, Michelle L. Wegscheid, David H. Gutmann, Jennifer N. Traber, Corina Anastasaki
Publikováno v:
Cell reports
SUMMARY Neurodevelopmental disorders are often caused by chromosomal microdeletions comprising numerous contiguous genes. A subset of neurofibromatosis type 1 (NF1) patients with severe developmental delays and intellectual disability harbors such a
Autor:
Kelly Hartigan, Nathan Kopp, Jiayang Chen, Jason B. Papke, Michelle L. Wegscheid, Corina Anastasaki, David H. Gutmann, Olivia Cobb, Joseph D. Dougherty
Publikováno v:
Stem Cell Reports
Summary Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder caused by a spectrum of distinct germline NF1 gene mutations, traditionally viewed as equivalent loss-of-function alleles. To specifically address the issue of mutational
Publikováno v:
Annals of Biomedical Engineering. 44:3468-3477
Peripheral nerve injuries present challenges to regeneration. Currently, the gold standard for nerve repair is an autograft that results in another region of the body suffering nerve damage. Previously, bioactive borate glass (BBG) has been studied i
Publikováno v:
ACS chemical neuroscience. 8(10)
Calcein, a fluorescent fluid phase marker, has been used to track and visualize cellular processes such as synaptic vesicle fusion. It is also the fluorophore for live cells in the commonly used Live/Dead viability assay. In pilot studies designed to
Autor:
Amy B. Harkins, Jason B. Papke, Rebecca Kuntz Willits, Lauren R. Counts, Robert D. Adams, Sara R. Rendell
Publikováno v:
Annals of Biomedical Engineering. 42:1282-1291
Electrical and chemical stimulation have been studied as potent mechanisms of enhancing nerve regeneration and wound healing. However, it remains unclear how electrical stimuli affect nerve growth, particularly in the presence of neurotrophic factors
Publikováno v:
Electroanalysis. 23:2757-2763
Carbon-fiber amperometry is a real-time analytical tool to detect vesicle release events from individual secretory cells. This study compared the spike events released in response to local or global depolarization. We describe each spike shape that r
Autor:
William H. Roden, Jason B. Papke, Johnnie M. Moore, Anne L. Cahill, Amy B. Harkins, Heather Macarthur
Publikováno v:
American Journal of Physiology-Cell Physiology. 293:C1742-C1752
In sympathetic neurons, it is well-established that the neurotransmitters, norepinephrine (NE), neuropeptide Y (NPY), and ATP are differentially coreleased from the same neurons. In this study, we determined whether synaptotagmin (syt) I, the primary
Publikováno v:
BMC Neuroscience, Vol 11, Iss 1, p 104 (2010)
BMC Neuroscience
BMC Neuroscience
Background The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca2+-independent isoform has been implicated in transmitter r
Publikováno v:
The FASEB Journal. 20