Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jason B. Muhitch"'
Autor:
Angela L. Hughson, Gary Hannon, Noah A. Salama, Tara G. Vrooman, Caroline A. Stockwell, Bradley N. Mills, Jesse Garrett-Larsen, Haoming Qiu, Roula Katerji, Lauren Benoodt, Carl J. Johnston, Joseph D. Murphy, Emma Kruger, Jian Ye, Nicholas W. Gavras, David C. Keeley, Shuyang S. Qin, Maggie L. Lesch, Jason B. Muhitch, Tanzy M.T. Love, Laura M. Calvi, Edith M. Lord, Nadia Luheshi, Jim Elyes, David C. Linehan, Scott A. Gerber
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102350- (2024)
Pronounced T cell exhaustion characterizes immunosuppressive tumors, with the tumor microenvironment (TME) employing multiple mechanisms to elicit this suppression. Traditional immunotherapies, such as immune checkpoint blockade, often fail due to th
Externí odkaz:
https://doaj.org/article/f027f2b3c534440cbdc1ca41fe01b771
Autor:
Christopher J. Greene, Kristopher Attwood, Nitika J. Sharma, Benjamin Balderman, Rongia Deng, Jason B. Muhitch, Gary J. Smith, Kenneth W. Gross, Bo Xu, Eric C. Kauffman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Iron is a potent catalyst of oxidative stress and cellular proliferation implicated in renal cell carcinoma (RCC) tumorigenesis, yet it also drives ferroptosis that suppresses cancer progression and represents a novel therapeutic target for advanced
Externí odkaz:
https://doaj.org/article/f6b91ca2c5c249dc9afb505e6f186f2e
Autor:
Fumito Ito, Trupti D. Vardam, Michelle M. Appenheimer, Kevin H. Eng, Sandra O. Gollnick, Jason B. Muhitch, Sharon S. Evans
Publikováno v:
International Journal of Hyperthermia, Vol 36, Iss 0, Pp 22-36 (2019)
Purpose: The aim of this study is to investigate whether radiofrequency ablation (RFA) improves the efficacy of adoptive T cell immunotherapy in preclinical mouse cancer models. Method: Mice implanted subcutaneously (sc) with syngeneic colon adenocar
Externí odkaz:
https://doaj.org/article/b38ac1ff40ff47bfb08165de3816b4ba
Autor:
Jason B. Muhitch, Nicholas C. Hoffend, Gissou Azabdaftari, Austin Miller, Wiam Bshara, Carl D. Morrison, Thomas Schwaab, Scott I. Abrams
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Tumor-associated macrophages have been well-characterized in solid malignancies, including renal cell carcinoma and generally correlate with poor prognosis. However, the molecular mechanisms which govern intratumoral macrophage behavior and
Externí odkaz:
https://doaj.org/article/e4701ddebf774665811e8d7e4d12c060
Autor:
Daniel T. Fisher, Jason B. Muhitch, Minhyung Kim, Kurt C. Doyen, Paul N. Bogner, Sharon S. Evans, Joseph J. Skitzki
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Intravital microscopy has been used in laboratory animals to visualise the blood vessels in tumours. Here, the authors use this technique in melanoma patients undergoing surgery and show that vessels in situhave a larger diameter than excised tissue
Externí odkaz:
https://doaj.org/article/4c243fca4982431b9c53e89ecd44d2df
Autor:
Patrick M. Boland, Renuka Iyer, Pawel Kalinski, Jennifer A. Jurcevic, Karen A. Hicks, Kristopher Attwood, Alan D. Hutson, Chong Wang, Scott I. Abrams, Jason B. Muhitch, Erik S. Knudsen, Hanna R. Rosenheck, Ram Nambiar, Hans Minderman, Orla Maguire, Agnieszka K. Witkiewicz, Joel Saltzman, Sarbajit Mukherjee, David L. Bajor, Christos Fountzilas
T-cell infiltration for patient LH-01-26 with BRAF V600 mutation in comparison to study population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8353c4f2e2360c24923a91498af6f545
https://doi.org/10.1158/1078-0432.22482590.v1
https://doi.org/10.1158/1078-0432.22482590.v1
Autor:
Patrick M. Boland, Renuka Iyer, Pawel Kalinski, Jennifer A. Jurcevic, Karen A. Hicks, Kristopher Attwood, Alan D. Hutson, Chong Wang, Scott I. Abrams, Jason B. Muhitch, Erik S. Knudsen, Hanna R. Rosenheck, Ram Nambiar, Hans Minderman, Orla Maguire, Agnieszka K. Witkiewicz, Joel Saltzman, Sarbajit Mukherjee, David L. Bajor, Christos Fountzilas
Multispectral immunofluorescence. Number of cells positive for exhaustion (PD-L1, TIM3, LAG3, CTLA4) and activation markers (OX40) in baseline tumor specimens (A); Quantitation of signals per specimen (B). There are more PDL1 positive tumor cell in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0593ee4c25f03ae86a60bf0b6fbe151b
https://doi.org/10.1158/1078-0432.22482602
https://doi.org/10.1158/1078-0432.22482602
Autor:
Jason B. Muhitch, Thomas Schwaab, Scott I. Abrams, Junko Matsuzaki, Kunle Odunsi, Wiam Bshara, Graham W. Warren, Lalith K. Kumaraswamy, Leighton C. Stein, Nicholas C. Hoffend, Austin Miller, Lilia Heit, Vincent Goritz, Mohammad Habiby Kermany, Timothy B. Winslow, Anurag K. Singh
Purpose: While stereotactic body radiotherapy (SBRT) can reduce tumor volumes in patients with metastatic renal cell carcinoma (mRCC), little is known regarding the immunomodulatory effects of high-dose radiation in the tumor microenvironment. The ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48da3407f3dc47421d384bf0509b61d
https://doi.org/10.1158/1078-0432.c.6526448
https://doi.org/10.1158/1078-0432.c.6526448
Autor:
Jason B. Muhitch, Thomas Schwaab, Scott I. Abrams, Junko Matsuzaki, Kunle Odunsi, Wiam Bshara, Graham W. Warren, Lalith K. Kumaraswamy, Leighton C. Stein, Nicholas C. Hoffend, Austin Miller, Lilia Heit, Vincent Goritz, Mohammad Habiby Kermany, Timothy B. Winslow, Anurag K. Singh
Supplementary figure S3 shows gating strategy and isotype staining of live tumor cells used for patient samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f35a07ca3caf75c3a14776afa288e9
https://doi.org/10.1158/1078-0432.22466849
https://doi.org/10.1158/1078-0432.22466849
Autor:
Jason B. Muhitch, Thomas Schwaab, Scott I. Abrams, Junko Matsuzaki, Kunle Odunsi, Wiam Bshara, Graham W. Warren, Lalith K. Kumaraswamy, Leighton C. Stein, Nicholas C. Hoffend, Austin Miller, Lilia Heit, Vincent Goritz, Mohammad Habiby Kermany, Timothy B. Winslow, Anurag K. Singh
Supplementary table 3 shows immunohistochemical antibodies and dilutions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7d7f074c2a6a47cb6b8d1cd256a9e6
https://doi.org/10.1158/1078-0432.22466834
https://doi.org/10.1158/1078-0432.22466834