Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jason B. Cross"'
Autor:
Ying Lai, Michael J. Tuvim, Jeremy Leitz, John Peters, Richard A. Pfuetzner, Luis Esquivies, Qiangjun Zhou, Barbara Czako, Jason B. Cross, Philip Jones, Burton F. Dickey, Axel T. Brunger
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different speci
Externí odkaz:
https://doaj.org/article/a5d10121e3a641d6bd7fa03f7507213a
Publikováno v:
Drug Discovery Today. 27:967-984
Artificial intelligence (AI) is becoming an integral part of drug discovery. It has the potential to deliver across the drug discovery and development value chain, starting from target identification and reaching through clinical development. In this
Autor:
Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2 inhibition has demonstrated tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679aa5c2787960118aa25b0d20d0a771
https://doi.org/10.1158/0008-5472.c.6512119.v1
https://doi.org/10.1158/0008-5472.c.6512119.v1
Autor:
Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun
Supplementary Materials and Methods Supplementary References Tables S1 to S3 and legends Figures S1 to S4 and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb5082d82bd02f09e6060ee7ba89279
https://doi.org/10.1158/0008-5472.22425706.v1
https://doi.org/10.1158/0008-5472.22425706.v1
Autor:
Barbara, Czako, Yuting, Sun, Timothy, McAfoos, Jason B, Cross, Paul G, Leonard, Jason P, Burke, Christopher L, Carroll, Ningping, Feng, Angela L, Harris, Yongying, Jiang, Zhijun, Kang, Jeffrey J, Kovacs, Pijus, Mandal, Brooke A, Meyers, Faika, Mseeh, Connor A, Parker, Simon S, Yu, Christopher C, Williams, Qi, Wu, Maria Emilia, Di Francesco, Giulio, Draetta, Timothy, Heffernan, Joseph R, Marszalek, Nancy E, Kohl, Philip, Jones
Publikováno v:
Journal of medicinal chemistry. 64(20)
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) plays a role in receptor tyrosine kinase (RTK), neurofibromin-1 (NF-1), and Kirsten rat sarcoma virus (KRAS) mutant-driven cancers, as well as in RTK-mediated resistance, making the identifi
Autor:
Jacqulyne P, Robichaux, Xiuning, Le, R S K, Vijayan, J Kevin, Hicks, Simon, Heeke, Yasir Y, Elamin, Heather Y, Lin, Hibiki, Udagawa, Ferdinandos, Skoulidis, Hai, Tran, Susan, Varghese, Junqin, He, Fahao, Zhang, Monique B, Nilsson, Lemei, Hu, Alissa, Poteete, Waree, Rinsurongkawong, Xiaoshan, Zhang, Chenghui, Ren, Xiaoke, Liu, Lingzhi, Hong, Jianjun, Zhang, Lixia, Diao, Russell, Madison, Alexa B, Schrock, Jennifer, Saam, Victoria, Raymond, Bingliang, Fang, Jing, Wang, Min Jin, Ha, Jason B, Cross, Jhanelle E, Gray, John V, Heymach
Publikováno v:
Nature. 597(7878)
Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18-21 and are established driver mutations in non-small cell lung cancer (NSCLC)
Autor:
Xin Zhang, Yuchuan Wu, Alexander Heifetz, Jan Antoinette C. Romero, J. Christian Baber, M. Dominic Ryan, Eric Humphries, Katie Hall, Sabrina Stucka, Jason B. Cross, Jing Zhang, Haoqun Chandonnet, Lippa Blaise S
Publikováno v:
Journal of Computer-Aided Molecular Design. 32:573-582
Antagonism of CCR9 is a promising mechanism for treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. There is limited experimental data on CCR9 and its ligands, complicating efforts to identify new small molecule
Autor:
Kien T. Nguyen, Chester A. Metcalf, Douglas Bevan, Jan Antoinette C. Romero, Bin Wang, Dominic Ryan, Jing Zhang, Jared Silverman, Felix Epie, Anu Daniel, Nicole M. Carter, Terence Moy, Yanzhi Zhang, Jason B. Cross, Ajit Chavan, Lippa Blaise S, Qingyi Yang, Katherine M. Poutsiaka, Joseph Shotwell, Roland E. Dolle, Brian Chamberlain, Xin Zhang
Publikováno v:
Journal of Medicinal Chemistry. 58:8503-8512
The emergence and spread of multidrug resistant bacteria are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed. We report on the discovery of azaindole u
Autor:
Jason B, Cross
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1705
Virtual screening (VS) has become an integral part of the drug discovery process and is a valuable tool for finding novel chemical starting points for GPCR targets. Ligand-based VS makes use of biochemical data for known, active compounds and has bee
Autor:
Jing Zhang, Jason B. Cross, Sabrina Stucka, Audrey Chan, Brian Chamberlain, Haoqun Chandonnet, Mustafa Varoglu, Lippa Blaise S, Dominic Ryan, Jan Antoinette C. Romero, Jennifer Goss
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3661-3664
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, affects millions of people worldwide. CCR9 has been shown to be a key chemokine receptor mediating the local inflammatory responses in the GI tract. The CCR9 inhibitor Verc