Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jason B Williams"'
Autor:
Christina Martins, Mariana Silva, Erik Rasbach, Praveen Singh, Yuta Itoh, Jason B. Williams, Edith Statham, Anna Meurer, Daniela V. Martinez, Anne Brandenburg, Markus V. Heppt, Steven R. Barthel, Tobias Schatton
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Monoclonal antibodies (abs) targeting the programmed cell death 1 (PD-1) immune checkpoint pathway have revolutionized tumor therapy. Because T-cell-directed PD-1 blockade boosts tumor immunity, anti-PD-1 abs have been developed for examinin
Externí odkaz:
https://doaj.org/article/d2e344242cfd4990a98e6ad3d7dce9a7
Autor:
Jason B. Williams, Shuyin Li, Emily F. Higgs, Alexandra Cabanov, Xiaozhong Wang, Haochu Huang, Thomas F. Gajewski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Melanoma is a cancer that responds relatively well to immunotherapy but resistance does ensue. Here, the authors show that loss of IFNGR2 or JAK1 in a melanoma cell line enhances T cell mediated lysis, however these cells are paradoxically more sensi
Externí odkaz:
https://doaj.org/article/05f527948e2246e587a6a28eb959a7ed
Autor:
Thomas F. Gajewski, Stefani Spranger, Alexandra Cabanov, Jason B. Williams, Brendan L. Horton
Four supplemental figures and their legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f2cb9badce18552ee75fc670cfb53b
https://doi.org/10.1158/2326-6066.22539986.v1
https://doi.org/10.1158/2326-6066.22539986.v1
Autor:
Thomas F. Gajewski, Stefani Spranger, Alexandra Cabanov, Jason B. Williams, Brendan L. Horton
Subsets of human tumors are infiltrated with tumor antigen–specific CD8+ T cells [tumor-infiltrating lymphocytes (TILs)] despite tumor progression. These TILs are thought to be inactivated by the immunosuppressive tumor microenvironment, through th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2b2119bb70e6d1b4bba5e6f626c6b2
https://doi.org/10.1158/2326-6066.c.6549245.v1
https://doi.org/10.1158/2326-6066.c.6549245.v1
Autor:
Alan J. Tackett, Gang Greg Wang, Thomas F. Gajewski, Nukhet Aykin-Burns, Rick D. Edmondson, Samuel G. Mackintosh, Tung-Chin Chiang, Kimberly J. Krager, Jason B. Williams, Hidetaka Uryu, Jeong Hyun Ahn, Samrat Roy Choudhury, Charity L. Washam, Allen J. Gies, Stephanie D. Byrum, Aaron J. Storey, Erin M. Taylor, Bradley D. Shields, Brian Koss
T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2aed658cb8479aa41c12a11abbf7a0
https://doi.org/10.1158/0008-5472.c.6512143.v1
https://doi.org/10.1158/0008-5472.c.6512143.v1
Autor:
Alan J. Tackett, Gang Greg Wang, Thomas F. Gajewski, Nukhet Aykin-Burns, Rick D. Edmondson, Samuel G. Mackintosh, Tung-Chin Chiang, Kimberly J. Krager, Jason B. Williams, Hidetaka Uryu, Jeong Hyun Ahn, Samrat Roy Choudhury, Charity L. Washam, Allen J. Gies, Stephanie D. Byrum, Aaron J. Storey, Erin M. Taylor, Bradley D. Shields, Brian Koss
Figure S1-7. Figure S1: Assessing the effect of EZH2i on in vitro T cell cytotoxic function. Figure S2: Systems approach uncovers drivers of T cell exhaustion resulting from EZH2-inhibtion. Figure S3: Loss of EZH2 function leads to metabolic exhausti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7199995713bf285261746195a1b94520
https://doi.org/10.1158/0008-5472.22425820
https://doi.org/10.1158/0008-5472.22425820
Autor:
Jeong Hyun Ahn, Kimberly J. Krager, Allen Gies, Rick D. Edmondson, Jason B. Williams, Bradley D. Shields, Samuel G. Mackintosh, Tung-Chin Chiang, Stephanie D. Byrum, Hidetaka Uryu, Samrat Roy Choudhury, Alan J. Tackett, Charity L. Washam, Erin M. Taylor, Thomas F. Gajewski, Nukhet Aykin-Burns, Aaron J. Storey, Gang Greg Wang, Brian Koss
Publikováno v:
Cancer Research. 80:4707-4719
T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources
Combining affective intelligence with learning to improve action selection in decision-making agents
Autor:
Jason B. Williams, Xiaoqin Zhang
Publikováno v:
International Journal of Hybrid Intelligent Systems. 15:27-53
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo
659 Blocking cytokine IL-1 with anakinra for the prevention of cytokine release syndrome in COVID-19
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background The novel coronavirus, known as SARS-CoV-2, or COVID-19 became a pandemic in early 2020, causing significant human suffering and economic woes globally. The pathophysiology of acute respiratory failure may be related to a robust immune rea