Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jason B, Cross"'
Autor:
Ying Lai, Michael J. Tuvim, Jeremy Leitz, John Peters, Richard A. Pfuetzner, Luis Esquivies, Qiangjun Zhou, Barbara Czako, Jason B. Cross, Philip Jones, Burton F. Dickey, Axel T. Brunger
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different speci
Externí odkaz:
https://doaj.org/article/a5d10121e3a641d6bd7fa03f7507213a
Autor:
Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2 inhibition has demonstrated tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679aa5c2787960118aa25b0d20d0a771
https://doi.org/10.1158/0008-5472.c.6512119.v1
https://doi.org/10.1158/0008-5472.c.6512119.v1
Publikováno v:
Drug Discovery Today. 27:967-984
Artificial intelligence (AI) is becoming an integral part of drug discovery. It has the potential to deliver across the drug discovery and development value chain, starting from target identification and reaching through clinical development. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c96a08b9ecf88e12f06dbd0c02a032e
https://doi.org/10.1016/j.drudis.2021.11.023
https://doi.org/10.1016/j.drudis.2021.11.023
Autor:
Barbara, Czako, Yuting, Sun, Timothy, McAfoos, Jason B, Cross, Paul G, Leonard, Jason P, Burke, Christopher L, Carroll, Ningping, Feng, Angela L, Harris, Yongying, Jiang, Zhijun, Kang, Jeffrey J, Kovacs, Pijus, Mandal, Brooke A, Meyers, Faika, Mseeh, Connor A, Parker, Simon S, Yu, Christopher C, Williams, Qi, Wu, Maria Emilia, Di Francesco, Giulio, Draetta, Timothy, Heffernan, Joseph R, Marszalek, Nancy E, Kohl, Philip, Jones
Publikováno v:
Journal of medicinal chemistry. 64(20)
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) plays a role in receptor tyrosine kinase (RTK), neurofibromin-1 (NF-1), and Kirsten rat sarcoma virus (KRAS) mutant-driven cancers, as well as in RTK-mediated resistance, making the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef1c5b3d344a33f3d6564080b26ff7f2
https://pubmed.ncbi.nlm.nih.gov/34643390
https://pubmed.ncbi.nlm.nih.gov/34643390
Autor:
Jacqulyne P, Robichaux, Xiuning, Le, R S K, Vijayan, J Kevin, Hicks, Simon, Heeke, Yasir Y, Elamin, Heather Y, Lin, Hibiki, Udagawa, Ferdinandos, Skoulidis, Hai, Tran, Susan, Varghese, Junqin, He, Fahao, Zhang, Monique B, Nilsson, Lemei, Hu, Alissa, Poteete, Waree, Rinsurongkawong, Xiaoshan, Zhang, Chenghui, Ren, Xiaoke, Liu, Lingzhi, Hong, Jianjun, Zhang, Lixia, Diao, Russell, Madison, Alexa B, Schrock, Jennifer, Saam, Victoria, Raymond, Bingliang, Fang, Jing, Wang, Min Jin, Ha, Jason B, Cross, Jhanelle E, Gray, John V, Heymach
Publikováno v:
Nature. 597(7878)
Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18-21 and are established driver mutations in non-small cell lung cancer (NSCLC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::690751a83c5308106525e50e6aa28f32
https://pubmed.ncbi.nlm.nih.gov/35590196
https://pubmed.ncbi.nlm.nih.gov/35590196
Autor:
Xin Zhang, Yuchuan Wu, Alexander Heifetz, Jan Antoinette C. Romero, J. Christian Baber, M. Dominic Ryan, Eric Humphries, Katie Hall, Sabrina Stucka, Jason B. Cross, Jing Zhang, Haoqun Chandonnet, Lippa Blaise S
Publikováno v:
Journal of Computer-Aided Molecular Design. 32:573-582
Antagonism of CCR9 is a promising mechanism for treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. There is limited experimental data on CCR9 and its ligands, complicating efforts to identify new small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde9eb16d466bc3420118aad3385a30a
https://doi.org/10.1007/s10822-018-0113-2
https://doi.org/10.1007/s10822-018-0113-2
Autor:
Jason B, Cross
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1705
Virtual screening (VS) has become an integral part of the drug discovery process and is a valuable tool for finding novel chemical starting points for GPCR targets. Ligand-based VS makes use of biochemical data for known, active compounds and has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::574246dcc4e26599387715f91813661f
https://pubmed.ncbi.nlm.nih.gov/29188566
https://pubmed.ncbi.nlm.nih.gov/29188566
Autor:
Kien T. Nguyen, Chester A. Metcalf, Douglas Bevan, Jan Antoinette C. Romero, Bin Wang, Dominic Ryan, Jing Zhang, Jared Silverman, Felix Epie, Anu Daniel, Nicole M. Carter, Terence Moy, Yanzhi Zhang, Jason B. Cross, Ajit Chavan, Lippa Blaise S, Qingyi Yang, Katherine M. Poutsiaka, Joseph Shotwell, Roland E. Dolle, Brian Chamberlain, Xin Zhang
Publikováno v:
Journal of Medicinal Chemistry. 58:8503-8512
The emergence and spread of multidrug resistant bacteria are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed. We report on the discovery of azaindole u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b67169430f8d7544a01fb0b95c703d
https://doi.org/10.1021/acs.jmedchem.5b00961
https://doi.org/10.1021/acs.jmedchem.5b00961
Autor:
Michael W. Wood, Jan Antoinette C. Romero, Yugui Gu, Yanzhi Zhang, Scott Coleman, Chester A. Metcalf, Ian Parr, Ajit Chavan, M. Dominic Ryan, Jason Kwong, Cassandra Abel, Jason B. Cross, Tongchuan Li, Jonathan F. Lawrence, Ole A. Andersen, Ryan Heney, Katherine M. Poutsiaka, Robert K. Y. Cheng, Felix Epie, Ning Yin, Liu Christopher Matthew, Audrey Chan, Cynthia Clark, Prudencio S. Herradura, Azard Mahamoon, Mary Conrad, Kien T. Nguyen, Jennifer Goss, Mark A. Brooks, Edward Clark, Jing Zhang, John M. Barker, Lippa Blaise S
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(8)
The emergence and spread of multidrug-resistant (MDR) Gram negative bacteria presents a serious threat for public health. Novel antimicrobials that could overcome the resistance problems are urgently needed. UDP-3-O-(R-3-hydroxymyristol)-N-acetylgluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08658c3019db1758d8d5c0ab1429532
https://pubmed.ncbi.nlm.nih.gov/28302397
https://pubmed.ncbi.nlm.nih.gov/28302397
Publikováno v:
Journal of Chemical Health & Safety. 21:4-13
Study purpose Currently, there is no OSHA or NIOSH monitoring method for subtilisin. This study evaluated a personal aerosol monitoring method for detection and quantification of subtilisin. The ACGIH ceiling limit and NIOSH short term exposure limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63471cfa734d97c47a3499ed3dba1fe9
https://doi.org/10.1016/j.jchas.2014.06.002
https://doi.org/10.1016/j.jchas.2014.06.002