Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jason A. Weesner"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103253- (2024)
Summary: Dynamic communication between intracellular organelles often takes place at specialized membrane contact sites that form between their membranes. Here we detail a procedure for the purification of endoplasmic reticulum-plasma membrane (ER-PM
Externí odkaz:
https://doaj.org/article/d063f8c374a34bb3a644ddba48c24647
Autor:
Jason A. Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G. Robinson, Yvan Campos, Ashutosh Mishra, Leigh E. Fremuth, Elida Gomero, Huimin Hu, Alessandra d’Azzo
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114117- (2024)
Summary: Endoplasmic reticulum-plasma membrane (ER-PM) junctions mediate Ca2+ flux across neuronal membranes. The properties of these membrane contact sites are defined by their lipid content, but little attention has been given to glycosphingolipids
Externí odkaz:
https://doaj.org/article/82ef0594197640f998e89cdc49f6a710
Autor:
Huimin Hu, Rosario Mosca, Elida Gomero, Diantha van de Vlekkert, Yvan Campos, Leigh E. Fremuth, Scott A. Brown, Jason A. Weesner, Ida Annunziata, Alessandra d’Azzo
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 644-658 (2021)
AAV-mediated gene therapy holds promise for the treatment of lysosomal storage diseases (LSDs), some of which are already in clinical trials. Yet, ultra-rare subtypes of LSDs, such as some glycoproteinoses, have lagged. Here, we report on a long-term
Externí odkaz:
https://doaj.org/article/4f4d2859730e48d497c3d91716323069
Autor:
Aimee N. Winter, Meena S. Subbarayan, Bethany Grimmig, Jason A. Weesner, Lauren Moss, Melinda Peters, Edwin Weeber, Kevin Nash, Paula C. Bickford
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that mediates communication between neurons and microglia. By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammatio
Externí odkaz:
https://doaj.org/article/3937848b251241b290cb3d4474efd3d7
Publikováno v:
FEBS Open Bio, Vol 13, Iss 9, Pp 1587-1600 (2023)
Intracellular organelles carry out many of their functions by engaging in extensive interorganellar communication through specialized membrane contact sites (MCSs) formed where two organelles tether to each other or to the plasma membrane (PM) withou
Externí odkaz:
https://doaj.org/article/e96877f81529489ba58e5be32f27bc97
Autor:
Jason Andrew Weesner, Ida Annunziata, Tianhong Yang, Walter Acosta, Elida Gomero, Huimin Hu, Diantha van de Vlekkert, Jorge Ayala, Xiaohui Qiu, Leigh Ellen Fremuth, David N. Radin, Carole L. Cramer, Alessandra d’Azzo
Publikováno v:
Cells, Vol 11, Iss 16, p 2579 (2022)
GM1-gangliosidosis is a catastrophic, neurodegenerative lysosomal storage disease caused by a deficiency of lysosomal β-galactosidase (β-Gal). The primary substrate of the enzyme is GM1-ganglioside (GM1), a sialylated glycosphingolipid abundant in
Externí odkaz:
https://doaj.org/article/05df366dd2894f4e94a3be11fe6fa3d9
Autor:
Xiaohui Qiu, Yvan Campos, Diantha van de Vlekkert, Elida Gomero, Ajay C. Tanwar, Ravi Kalathur, Jason A. Weesner, Antonella Bongiovanni, Jeroen Demmers, Alessandra d’Azzo
Publikováno v:
Journal of Biological Chemistry, 298(10):102425. American Society for Biochemistry and Molecular Biology Inc.
Alix is a ubiquitously expressed scaffold protein that participates in numerous cellular processes related to the remodeling/repair of membranes and the actin cytoskeleton. Alix exists in monomeric and dimeric/multimeric configurations, but how dimer
Autor:
Leigh E. Fremuth, Huimin Hu, Diantha van de Vlekkert, Jason A. Weesner, Elida M. Gomero, Alessandra d'Azzo
Publikováno v:
Molecular Genetics and Metabolism. 138:107105
Autor:
Jason A. Weesner, Diantha van de Vlekkert, Walter L. Acosta, Tianhong Yang, Elida M. Gomero, Huimin Hu, David Radin, Carole L. Cramer, Alessandra d'Azzo
Publikováno v:
Molecular Genetics and Metabolism. 138:107356
Autor:
Edwin J. Weeber, Bethany Grimmig, Melinda M. Peters, Paula C. Bickford, Kevin Nash, Jason A. Weesner, Lauren D. Moss, Aimee N. Winter, Meena S. Subbarayan
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that mediates communication between neurons and microglia. By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammation within