Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jason A. Mulder"'
Autor:
Yanchao Xin, Frank Roschangar, Zeena Williams, Denis Byrne, Dmitry Kurouski, Jason A. Mulder, Jinhua J. Song, Alice T. Granger, Laurence J. Nummy, Jon C. Lorenz, Scott Pennino, Frederic G. Buono, Chris H. Senanayake, Yaping Hong, Ajith Premasiri, Nathan K. Yee, Joe Gao, Sonia Rodriguez, Xinzhu Zhang, Bo Qu, Jack D. Brown, Rogelio P. Frutos, Bikshandarkoil A. Narayanan, Zhantong Mao, Azad Hossain, Ning Li, Mariusz Krawiec, Heewon Lee, Yongda Zhang, Zhengxu S. Han, Nizar Haddad, Zhibin Li, Yibo Xu, Nelu Grinberg, Joshua D. Sieber, Carl A. Busacca
Publikováno v:
The Journal of Organic Chemistry. 83:1448-1461
A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in five steps from the chiral auxiliary in 36% overall yield. Separtion and recovery of the auxil
Autor:
Zhidong Chen, Carl A. Busacca, Shengli Ma, Xingzhong Zeng, Peter Allen Nemoto, Paige E. Mahaney, Jason A. Mulder, Chris H. Senanayake, Jun Wang, Nitinchandra D. Patel, Zhibin Li, Todd Bosanac, Daniel R. Fandrick, Jean-Nicolas Desrosiers, Heewon Lee, Sonia Rodriguez, Jon C. Lorenz, Nathan K. Yee, Joe Gao, Nelu Grinberg, Hidenori Takahashi, Alessandra Bartolozzi, Jinhua J. Song, Keith R. Fandrick
Publikováno v:
Organic Process Research & Development. 21:1427-1434
A practical and efficient synthesis of the FLAP inhibitor 1 was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separ
Autor:
Sonia Rodriguez, Jason A. Mulder, Chris H. Senanayake, Bing-Shiou Yang, Tampone Thomas G, Nathan K. Yee, Rogelio P. Frutos
Publikováno v:
Organic Process Research & Development. 20:982-988
A practical, safe, and efficient process for the synthesis of PDE4 (phosphodiesterase type 4) inhibitors represented by 1 and 2 was developed and demonstrated on a multi-kilogram scale. Key aspects of the process include the regioselective synthesis
Autor:
Keith R. Fandrick, Nitinchandra D. Patel, Nelu Grinberg, Heewon Lee, Nathan K. Yee, Shengli Ma, Kanwar Sidhu, Yongda Zhang, Carl A. Busacca, Jason A. Mulder, Jinhua J. Song, Zhibin Li, Joe Gao, Jon C. Lorenz, Melissa A. Herbage, Chris H. Senanayake
Publikováno v:
Organic Process Research & Development. 20:95-99
A practical and cost-effective synthesis of (2-aminopyrimidin-5-yl) boronic acid 1b has been developed. Key features of the synthesis include the inexpensive in situ protection of the amine via bis-silylation using TMSCl followed by metal–halogen e
Autor:
Yuwen Wang, Frank Roschangar, Joseph Kaloko, Heewon Lee, Sanjit Sanyal, Jason A. Mulder, Ling Wu, Daniel R. Fandrick, Matthias Hoffmann, Chris H. Senanayake
Publikováno v:
Organic Letters. 17:2964-2967
A Michael equilibration model is presented to provide for site-selective pyrazole condensations between alkoxyacrylonitriles and hydrazines. Both pyrazole isomers were accessed with high selectivity by employment of kinetically or thermodynamically c
Autor:
Xingzhong Zeng, Nathan K. Yee, Nizar Haddad, Melissa A. Herbage, Joe J. Gao, Xudong Wei, Sonia Rodriguez, Bo Qu, Chris H. Senanayake, Shengli Ma, Heewon Lee, Jason A. Mulder, Nelu Grinberg, Keith R. Fandrick, Jinhua J. Song, Jean-Nicolas Desrosiers
Publikováno v:
Angewandte Chemie International Edition. 53:12153-12157
An enantioselective copper-catalyzed asymmetric conjugate addition of Me2Zn to (Z)-nitroalkenes led to the formation of all-carbon quaternary stereogenic centers with high stereoselectivity. The key features of the new method are the unprecedented us
Autor:
Heewon Lee, Rolf Schmid, Nelu Grinberg, Daniel R. Fandrick, Keith R. Fandrick, Jinhua J. Song, Adil Duran, Shengli Ma, Joe Gao, Elizabeth Archer, Nathan K. Yee, Jason A. Mulder, Juergen Daeubler, Carl A. Busacca, Michael Konrad, Nitinchandra D. Patel, Chris H. Senanayake, Frederic G. Buono
Publikováno v:
Organic Letters. 16:4360-4363
A practical noncryogenic process for the Aggarwal stereospecific boronate rearrangement with chiral secondary benzylic carbamates has been developed. The use of LDA instead of sec-BuLi combined with an in situ trapping of the unstable lithiated carba
Autor:
Bo Qu, Jason A. Mulder, Max Sarvestani, Rogelio P. Frutos, Nizar Haddad, Jinhua J. Song, Tampone Thomas G, Magnus C. Eriksson, Nitinchandra D. Patel, Sherry Shen, Xiufeng Sun, Joe Gao, Chris H. Senanayake
Publikováno v:
Organic Process Research & Development. 17:940-945
Reported herein is a safe and economical synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate, an intermediate in the synthesis of novel anti-infective agents. The key to this process is the trifluoromethylation of an aryl iodide using an inexp
Total Synthesis of (+)-Azaspiracid-1. An Exhibition of the Intricacies of Complex Molecule Synthesis
Autor:
David A. Evans, Edward J. Olhava, Travis B. Dunn, Lisbet Kværnø, André Beauchemin, Martin Juhl, Brian Raymer, Katsuji Kagechika, David A. Favor, Jason A. Mulder
Publikováno v:
Journal of the American Chemical Society. 130:16295-16309
The synthesis of the marine neurotoxin azaspiracid-1 has been accomplished. The individual fragments were synthesized by catalytic enantioselective processes: A hetero-Diels-Alder reaction to afford the E- and HI-ring fragments, a carbonyl-ene reacti
Autor:
David A. Evans, Travis B. Dunn, Lisbet Kværnø, André Beauchemin, Brian Raymer, Edward J. Olhava, Jason A. Mulder, Martin Juhl, Katsuji Kagechika, David A. Favor
Publikováno v:
Angewandte Chemie. 119:4782-4787