Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jason A. Magida"'
Autor:
Ling-Wa Chong, S. M. Bukola Obayomi, Annette R. Atkins, Zong Wei, Ruth T. Yu, Liu Wang, Tae Gyu Oh, Gabriela Estepa, Jason A. Magida, Diana C. Hargreaves, Michael Downes, Jovylyn Gatchalian, Ronald M. Evans
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Glucocorticoids are widely prescribed antiinflammatory drugs that suppress inflammatory gene expression through activation of the glucocorticoid receptor (GR); however, the mechanisms of GR-mediated repression are not fully understood. W
Autor:
Jason A. Magida, Yuxiao Tan, Christopher E. Wall, Brooke C. Harrison, Thomas G. Marr, Angela K. Peter, Cecilia A. Riquelme, Leslie A. Leinwand
Publikováno v:
The Journal of general physiology. 154(4)
As an opportunistic predator, the Burmese python (Python molurus bivittatus) consumes large and infrequent meals, fasting for up to a year. Upon consuming a large meal, the Burmese python exhibits extreme metabolic responses. To define the pathways t
Autor:
Racheal N. McVicar, Karsten Zengler, Adam P. Cribbs, Alex E. Clark, Andrea Denardo, Elizabeth M. Kwong, Sydney A. Majowicz, Xin Yin, Ann Piermatteo, Daniel R. Sandoval, Joanna K.C. Coker, Chelsea Nora, Ben A. Croker, Udo Oppermann, Kaare V. Grunddal, Blake M. Hauser, Catrine Johansson, Mark A Tye, Gregory J. Golden, Timothy M. Caradonna, Jeffrey D. Esko, Martin Philpott, Anoop Narayanan, Philip L.S.M. Gordts, N Connor Payne, Joyce Jose, Eric R. Griffis, Sotirios Tsimikas, Ryan J. Weiss, Micheal Downes, Jason A. Magida, Thomas Mandel Clausen, Aaron G. Schmidt, Yuan Pu, Cameron J. Nowell, Carlo Ballatore, Thibault Alle, Charlotte B. Spliid, Jared Feldman, Ronald M. Evans, Sumit K. Chanda, Sandra L. Leibel, Aaron F. Garretson, James E. Dunford, Ralph Mazitschek, Aaron F. Carlin
Publikováno v:
bioRxiv
Summary ParagraphWe identify the prolyl-tRNA synthetase (PRS) inhibitor halofuginone1, a compound in clinical trials for anti-fibrotic and anti-inflammatory applications2, as a potent inhibitor of SARS-CoV-2 infection and replication. The interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3387ce706f91aec434a2d597280b9361
https://doi.org/10.1101/2021.03.22.436522
https://doi.org/10.1101/2021.03.22.436522
Autor:
Jason A. Magida, Ronald M. Evans
Publikováno v:
Proceedings of the National Academy of Sciences. 115:5051-5053
While 92 million Americans are currently estimated to have some form of cardiovascular disease (CVD), nearly one-half of adults in the United States are projected to develop CVD by 2030, annually eclipsing all other causes of death for the past centu
Autor:
Joseph L. Witztum, Nathanael J. Spann, Ronald M. Evans, Sotirios Tsimikas, Alan R. Saltiel, Xuchu Que, Michael Downes, Zhongji Liao, Tatiana Kisseleva, Fangli Zhou, Christopher K. Glass, David A. Brenner, Ty D. Troutman, Jason A. Magida, Peng Zhao, Xiaohong Yang, Xiaoli Sun, Jason S. Seidman, Martina P. Pasillas
Publikováno v:
Cell Metab
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are pro-inflammatory and pro-atherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown. Here, we show that OxPLs accumulate in human and mouse NASH. Using a t
Autor:
Leslie A. Leinwand, Jason A. Magida
Publikováno v:
EMBO Molecular Medicine
Familial hypertrophic cardiomyopathy (HCM) is largely caused by dominant mutations in genes encoding cardiac sarcomeric proteins, and it is etiologically distinct from secondary cardiomyopathies resulting from pressure/volume overload and neurohormon
Autor:
Robert M. Weiss, Kathy Zimmerman, Melissa K Davis, Robert M. Brooks, Donald D. Heistad, Gary L. Baumbach, Hardik Doshi, Donald D. Lund, Biyi Chen, Nathan D. Funk, Ramzi El Accaoui, Long-Sheng Song, Tariq Hameed, Georges P. Hajj, Yi Chu, Leslie A. Leinwand, Jason A. Magida
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 35(7)
Objective— We studied the mechanistic links between fibrocalcific changes in the aortic valve and aortic valve function in mice homozygous for a hypomorphic epidermal growth factor receptor mutation (Wave mice). We also studied myocardial responses
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 39:183-186
Intestinal epithelial cells (IEC) are known to produce monocyte chemoattractant protein-1 (MCP-1). However, MCP-1 production, as with many other cytokines, can be regulated by a network of cytokines present in the environment of the IEC. Both IEC and
Autor:
Leslie A. Leinwand, Jason A. Magida, Brooke C. Harrison, Christopher E. Wall, Stephen M. Secor, Thomas G. Marr, Cecilia Riquelme
Burmese pythons display a marked increase in heart mass after a large meal. We investigated the molecular mechanisms of this physiological heart growth with the goal of applying this knowledge to the mammalian heart. We found that heart growth in pyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec9983f8e95ea11d1f5d89eb5f07f94
https://europepmc.org/articles/PMC3383835/
https://europepmc.org/articles/PMC3383835/
Publikováno v:
In Vitro Cellular and Developmental Biology-Animal.