Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jason A. Halliwell"'
Autor:
Jason Alexander Halliwell, Javier Martin-Gonzalez, Adnan Hashim, John Arne Dahl, Eva R. Hoffmann, Mads Lerdrup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The timing of DNA replication in mammals is crucial for minimizing errors and influenced by genome usage and chromatin states. Replication timing in the newly formed mammalian embryo remains poorly understood. Here, we have investigated repl
Externí odkaz:
https://doaj.org/article/a28619d16a8d4704add66bf4ca318364
Publikováno v:
Current protocolsLiterature Cited. 2(11)
Human pluripotent stem cells (hPSCs) can be grown in culture indefinitely, making them a valuable tool for use in basic biology, disease modeling, and regenerative medicine. However, over prolonged periods in culture, hPSCs tend to acquire genomic ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0045ff3989fb13f633a7f0591d127bc
https://pubmed.ncbi.nlm.nih.gov/36426882
https://pubmed.ncbi.nlm.nih.gov/36426882
Autor:
Jason A. Halliwell, Eva Hoffmann
Publikováno v:
Cell
Genetic recombination generates novel trait combinations, and understanding how recombination is distributed across the genome is key to modern genetics. The PRDM9 protein defines recombination hotspots; however, megabase-scale recombination patterni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4772f7d01c0e30d34c9fc87bfecb6c7d
https://doi.org/10.1016/j.cell.2021.07.014
https://doi.org/10.1016/j.cell.2021.07.014
Autor:
Jonathon Carr, Jason Wray, Chela James, Christopher J. Price, Jason A. Halliwell, Charlotta Böiers, Tariq Enver, John Brown, Dylan Stavish, Thomas J. R. Frith, Peter W. Andrews, Ivana Barbaric, Ingrid Saldaña-Guerrero
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
We postulate that exit from pluripotency involves intermediates that retain pluripotency while simultaneously exhibiting lineage-bias. Using a MIXL1 reporter, we explore mesoderm lineage-bias within the human pluripotent stem cell compartment. We ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783bae19c509210a5f4e00479a6b2065
https://doaj.org/article/49cf589d5cb741e6a087de76d2e33465
https://doaj.org/article/49cf589d5cb741e6a087de76d2e33465
Autor:
Oliver J. Bower, Zoe Hewitt, Peter W. Andrews, Sherif F. El-Khamisy, Paul J. Gokhale, Dylan Stavish, Jason A. Halliwell, Christopher J. Price, Thomas J. R. Frith, Owen Laing, Ivana Barbaric
Publikováno v:
Stem Cell Reports
Summary Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900a2242e028f43789b4c6eefbf9736c
https://doi.org/10.1016/j.stemcr.2020.04.004
https://doi.org/10.1016/j.stemcr.2020.04.004
Autor:
Emma Betteridge, Peter W. Andrews, Jason Skelton, Jason A. Halliwell, Duncan Baker, Michael A. Quail, Kim Judge, Karen Oliver, Ivana Barbaric
Publikováno v:
Stem Cells and Development
Copy number variants (CNVs) are genomic rearrangements implicated in numerous congenital and acquired diseases, including cancer. The appearance of culture-acquired CNVs in human pluripotent stem cells (PSC) has prompted concerns for their use in reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e62bac339c9caee59a1c2a6354addb
https://pubmed.ncbi.nlm.nih.gov/33757297
https://pubmed.ncbi.nlm.nih.gov/33757297
Autor:
Karen Oliver, Michael A. Quail, Emma Betteridge, Peter W. Andrews, Jason Skelton, Ivana Barbaric, Duncan Baker, Kim Judge, Jason A. Halliwell
Copy number variants (CNVs) are genomic rearrangements implicated in numerous congenital and acquired diseases, including cancer. In human pluripotent stem cells (PSC), the appearance of culture-acquired CNVs prompted concerns for their use in regene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8afaa7eb60a742f388d3dea2755d95
https://doi.org/10.1101/2020.07.11.198382
https://doi.org/10.1101/2020.07.11.198382
Publikováno v:
Current Protocols in Stem Cell Biology. 54
Human pluripotent stem cells (PSC) acquire recurrent chromosomal instabilities during prolonged in vitro culture that threaten to preclude their use in cell-based regenerative medicine. The rapid proliferation of pluripotent cells leads to constituti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd2bba62e68c8f9bf1a751d2c9a528e
https://doi.org/10.1002/cpsc.115
https://doi.org/10.1002/cpsc.115
Autor:
Wagner Narciso de Campos, Juliana Doblas Massaro, Steven G.E. Marsh, Jason A. Halliwell, Eduardo Antônio Donadi, Celso T. Mendes-Junior, Ana de Lourdes Candolo Martinelli
Publikováno v:
HLA. 90:238-242
The HFE molecule controls iron uptake from gut, and defects in the molecule have been associated with iron overload, particularly in hereditary hemochromatosis. The HFE gene including both coding and boundary intronic regions were sequenced in 304 Br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220308f19e7cf2cdb9b75ce689f4339
https://doi.org/10.1111/tan.13097
https://doi.org/10.1111/tan.13097
Autor:
Christopher J. Price, John Brown, Peter W. Andrews, Dylan Stavish, Charlotta Böiers, Tariq Enver, Thomas J. R. Frith, Ivana Barbaric, Chela James, Jason A. Halliwell, Jonathon Carr
We postulate that exit from pluripotency involves intermediates that retain pluripotency while simultaneously exhibiting lineage-bias. Using a MIXL1 reporter, we explored mesoderm lineage-bias within the human pluripotent stem cell compartment. We id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1d6945651ecbb0852de029cb3426d5