Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jason A. Garness"'
Autor:
Blanche Capel, Jack D. Keene, Sofia Batchvarova, Josiah Hardy, Victor A. Ruthig, Tetsuhiro Yokonishi, Jason A. Garness, Matthew B Friedersdorf
Publikováno v:
Biol Reprod
In vertebrates, the RNA-binding protein (RBP) dead end 1 (DND1) is essential for primordial germ cell (PGC) survival and maintenance of cell identity. In multiple species, Dnd1 loss or mutation leads to severe PGC loss soon after specification or, in
Autor:
Robert S. Weiss, Timothy M. Pierpont, Claire M. Anderson, Amy M. Lyndaker, Jason A. Garness, Hilary Zhaoxu Hu, Jamie L. Roden, Teresa L. Southard, Matthew S. Cook, Nandita Kataria, Elizabeth S. Moore, Donald H. Schlafer, Lina Bagepalli, Blanche Capel, Alicia M Braxton, Qiming Jin
Publikováno v:
Cell Reports, Vol 21, Iss 7, Pp 1896-1909 (2017)
Summary: Testicular germ cell tumors (TGCTs) are among the most responsive solid cancers to conventional chemotherapy. To elucidate the underlying mechanisms, we developed a mouse TGCT model featuring germ cell-specific Kras activation and Pten inact
Autor:
Victor A. Ruthig, Blanche Capel, Corey Bunce, Steve C. Munger, Jack D. Keene, Matthew B Friedersdorf, Jason A. Garness
Publikováno v:
Development
The adult spermatogonial stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis around embryonic day 10.5 (E10.5). These cells undergo rapid mitotic proliferation, then enter a prolonged period of cell c
Publikováno v:
The International journal of developmental biology. 57(2-4)
Teratomas represent a critical interface between stem cells, differentiation and tumorigenesis. These tumors are composed of cell types representing all three germ layers reflecting the pluripotent nature of their cell of origin. The study of these c