Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jason A. Davy"'
Autor:
Mihaela M. Esanu, Edmund Leung, Nande Wright, Selcuk Calimsiz, Xiang Wang, Olivier St-Jean, Eric A. Standley, Guojun Yu, Li Wang, Dustin Bringley, Roberts Benjamin James, Jaspal Phull, Anna Chiu, Jason A. Davy, Doxsee Ian James, Jeffrey D. Ng, Wen-Tau T. Chang, Lennie Lin, Jenny Phoenix, David Allen Siler, Olga Lapina, Andrea Ambrosi, Youri Kim, Jeffrey A. O. Garber, Jinyu Shen, Bernard Kwong, Keshab Sarma, Bing Shi, Andrew Anthony Martins
Publikováno v:
Organic Process Research & Development. 25:1215-1236
This manuscript describes the chemical process development and multi-kilogram synthesis of rovafovir etalafenamide (GS-9131), a phosphonamidate prodrug nucleotide reverse transcriptase inhibitor un...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e6d25441ec292ea6d90f7f6942f094e
https://doi.org/10.1021/acs.oprd.1c00059
https://doi.org/10.1021/acs.oprd.1c00059
Autor:
Jonah W. Curl, Olivier St-Jean, Jason A. Davy, Olga Lapina, Sangsun Park, Mary Rosario, Jeffrey A. O. Garber, Sura Ha, Bernard Kwong, David Allen Siler, Selcuk Calimsiz, Keshab Sarma, Doxsee Ian James, Jinyu Shen, Jeffrey D. Ng, Lennie Lin, Guojun Yu, Jisung Lee
Publikováno v:
Organic Process Research & Development. 25:1263-1274
Fluorinated nucleoside 1 is a key starting material in the synthesis of rovafovir etalafenamide (2), a novel nucleotide reverse transcriptase inhibitor under development at Gilead Sciences for the ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26f676376f843d7c8975b05c66d15f0f
https://doi.org/10.1021/acs.oprd.1c00026
https://doi.org/10.1021/acs.oprd.1c00026
Autor:
Nande Wright, Roberts Benjamin James, Bernard Kwong, Keshab Sarma, Smith Mark, Alan Scott Triman, Elan Shao, Jason A. Davy, Andrew Anthony Martins, Jinyu Shen, Brandon Heath Brown, Dustin Bringley, Keiko Sujino, Selcuk Calimsiz, Detian Gao
Publikováno v:
Organic Process Research & Development. 25:1237-1246
As part of the synthesis of rovafovir etalafenamide, the development and manufacturing-scale demonstration of a dioxirane-mediated oxidative elimination is described. The reaction presented multipl...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::716ab3ca237293fc9365771f045b76d4
https://doi.org/10.1021/acs.oprd.0c00439
https://doi.org/10.1021/acs.oprd.0c00439
Publikováno v:
Tetrahedron. 71:2643-2657
Didemnaketals A and B are isolation artifacts whose exact structures have been the subject of recent controversy. Although the biological function of the presumed progenitor—didemnaketal C—remains unknown, both degradation products are inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647294861d4d71034e853036725111f1
https://doi.org/10.1016/j.tet.2015.03.043
https://doi.org/10.1016/j.tet.2015.03.043
Xanthates as Synthetic Equivalents of Oxyacyl Radicals: Access to Lactones under Tin-Free Conditions
Publikováno v:
The Journal of Organic Chemistry. 77:6332-6339
In addition to their utility in Barton-McCombie deoxygenations, xanthates can engage in 5-exo-trig radical cyclizations to afford lactones after oxidative workup. In this paper, we describe a tin-free protocol that provides direct access to lactones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c053959d72ffca43808922d728fb59f
https://doi.org/10.1021/jo300939f
https://doi.org/10.1021/jo300939f
Publikováno v:
Synthesis. 44:1854-1862
A novel, highly stereoselective tandem dihydroxylation, hemiketalization and conjugate addition reaction is reported that transforms a linear meso-functionalized bis-enone into a substituted singly anomeric spiroketal, effectively controlling six ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f36627271536d496d3793d23396a1f93
https://doi.org/10.1055/s-0031-1290817
https://doi.org/10.1055/s-0031-1290817
Publikováno v:
Journal of Sulfur Chemistry. 28:45-72
The inclusion of one or more sulfur atoms at the backbone of glycerophospholipids or phosphonolipids has created a number of new non-natural substrates for investigation in medicinal chemistry and enzymology. This review, containing 138 references, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e7681b6267690a69cda10b65bf52c0c
https://doi.org/10.1080/17415990601080166
https://doi.org/10.1080/17415990601080166
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:113-117
The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs were measured on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e678c5b47a0fe8f92dd46b5d22bcbb
https://doi.org/10.1016/j.bmcl.2006.09.083
https://doi.org/10.1016/j.bmcl.2006.09.083
Publikováno v:
ChemInform. 43
In the presence of BEt3 and air, some strained xanthates react with radical cyclization to afford fused lactones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a086f80a8f376bc837689c4bdc31a3a
https://doi.org/10.1002/chin.201249103
https://doi.org/10.1002/chin.201249103
Autor:
Robert H. Notter, Alan J. Waring, Adrian L. Schwan, Zhengdong Wang, Suneel P. Singh, Jason A. Davy, Frans J. Walther, Larry M. Gordon
Publikováno v:
MedChemComm. 2(12)
This paper reports the chemical synthesis and purification of a novel phospholipase-resistant C16:0, C16:1 diether phosphonoglycerol with structural analogy to ester-linked anionic phosphatidylglycerol (PG) in endogenous pulmonary surfactant. This di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2fa5b92e86b8b2c06aec1880884c8f
https://pubmed.ncbi.nlm.nih.gov/22530092
https://pubmed.ncbi.nlm.nih.gov/22530092