Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jason A. Cascio"'
Publikováno v:
Annals of Allergy, Asthma & Immunology. 129:254-255
Autor:
Habib Zaghouani, Alexis N. Cattin-Roy, Subhasis Barik, Jason S. Ellis, Jason A. Cascio, Tobechukwu K. Ukah, Mindy M. Miller
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(7)
IL-4 and IL-13 have been defined as anti-inflammatory cytokines that can counter myelin-reactive T cells and modulate experimental allergic encephalomyelitis. However, it is not known whether endogenous IL-4 and IL-13 contribute to the maintenance of
Autor:
Mindy M. Miller, Adam A. Zaghouani, John C. Hardaway, Jason A. Cascio, Linda M. Rowland, Fatma Betul Guloglu, Michael P. Sherman, Xiaoxiao Wan, Christine M. Hoeman, Mermagya Dhakal, Habib Zaghouani
Publikováno v:
European Journal of Immunology. 44:842-855
In this study, we examined the role IL-13 receptor alpha 1 (IL-13Rα1) plays in macrophage differentiation and function. The findings indicate that IL-13Rα1 is expressed on the M2 but not on the M1 subset of macrophages and specifically heterodimeri
Autor:
Mermagya Dhakal, Jason A. Cascio, Xiaoxiao Wan, Weirong Chen, Marie-Therese Khairallah, Mindy M. Miller, Linda M. Rowland, Habib Zaghouani
Publikováno v:
Journal of Neuroimmunology. 266:49-55
F 1 (SJL/J × C57BL/6) mice with MOG35–55-induced EAE recover from disease when treated with Ig-MOG carrying MOG35–55 peptide. However, Ig-PLP1, carrying PLP139–151, induced reduction of anti-MOG antibodies and exacerbated EAE. Herein, we show
Autor:
Jason A. Cascio, Jason S. Ellis, Mermagya Dhakal, Xiaoxiao Wan, Christine M. Hoeman, F. Betul Guloglu, Habib Zaghouani
Publikováno v:
The Journal of Immunology. 191:1126-1135
The events controlling the transition of T cells from effector to memory remain largely undefined. Many models have been put forth to account for the origin of memory precursors, but for CD4 T cells initial studies reported that memory T cells derive
Autor:
Xiaoxiao Wan, Christine M. Hoeman, Sarah Zaghouani, Amie M. VanMorlan, Jason A. Cascio, Mermagya Dhakal, F. Betul Guloglu, Habib Zaghouani, Linda M. Rowland
Publikováno v:
Diabetes
Immune modulation of pancreatic inflammation induces recovery from type 1 diabetes (T1D), but remission was not durable, perhaps because of an inability to sustain the formation and function of new pancreatic β-cells. We have previously shown that I
Autor:
Mermagya Dhakal, Sarah Zaghouani, Xiaoxiao Wan, Marie Therese Khairallah, Weirong Chen, Habib Zaghouani, Rohit D. Divekar, Linda M. Rowland, Cara L. Haymaker, Jason A. Cascio
Publikováno v:
The Journal of Immunology. 190:6004-6014
Dendritic cells (DCs) have been shown to play a major role in oral tolerance, and this function has been associated with their ability to produce anti-inflammatory cytokines and to induce suppressive regulatory T cells. In this study, we demonstrate
Autor:
Danielle M. Tartar, Jason A. Cascio, F. Betul Guloglu, Habib Zaghouani, Xiaoxiao Wan, Christine M. Hoeman, Amie M. VanMorlan, Jason S. Ellis, Mermagya Dhakal, Seung Hi Yahng, Cara L. Haymaker
Publikováno v:
The Journal of Immunology. 185:3149-3157
The role APCs play in the transition of T cells from effector to memory remains largely undefined. This is likely due to the low frequency at which long-lived T cells arise, which hinders analysis of the events involved in memory development. In this
Autor:
Mermagya Dhakal, Habib Zaghouani, Mohamed Oukka, Amie M. VanMorlan, Cara L. Haymaker, Renu Jain, F. Betul Guloglu, Xiaoxiao Wan, Jason A. Cascio, Christine M. Hoeman, Jason S. Ellis, Danielle M. Tartar
Publikováno v:
The Journal of Immunology. 184:3377-3385
Recently, traces of double-positive FoxP3+RORγt+ T cells were identified and viewed as dual programming differentiation intermediates geared toward development into T regulatory or Th17 cells. In this study, we report that FoxP3+RORγt+ intermediate
Autor:
Jason A. Cascio, Renu Jain, Austin Ostermeier, John C. Hardaway, Rohit D. Divekar, Cara L. Haymaker, Habib Zaghouani, Ping Yu, Danielle M. Tartar, Jason S. Ellis, Christine M. Hoeman
Publikováno v:
The Journal of Immunology. 181:73-80
Lately, it has become clear that regulatory T cells (Tregs) play a major role in the maintenance of peripheral tolerance and control of autoimmunity. Despite these critical functions, the process underlying the development of Tregs remains largely un