Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Jason A. Butler"'
Autor:
Pradeep Ramalingam, Michael C. Gutkin, Michael G. Poulos, Taylor Tillery, Chelsea Doughty, Agatha Winiarski, Ana G. Freire, Shahin Rafii, David Redmond, Jason M. Butler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Aging associated defects within stem cell-supportive niches contribute towards age-related decline in stem cell activity. However, mechanisms underlying age-related niche defects, and whether restoring niche function can improve stem cell fi
Externí odkaz:
https://doaj.org/article/bfeb0e9c16e84018b805b3d540fe3b9c
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.
Externí odkaz:
https://doaj.org/article/20905f69c37543e4b5a99130d19e5860
Publikováno v:
KONA Powder and Particle Journal, Vol 39, Iss 0, Pp 84-99 (2021)
Inherent challenges regarding the rheological characterization of slurries of elongated particles have necessitated the development of alternatives to standardized rheometers. These methods of measurement, and the associated advances in the quantific
Externí odkaz:
https://doaj.org/article/75a962acc60843c4a5579a2432273e72
Autor:
Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppr
Externí odkaz:
https://doaj.org/article/6b54770221c34086b376c539aef6277a
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Sponge-like biomaterials formed from silk fibroin are promising as degradable materials in clinical applications due to their controllable breakdown into simple amino acids or small peptides in vivo. Silk fibroin, isolated from Bombyx mori silkworm c
Externí odkaz:
https://doaj.org/article/5a99c844169047bcb2afa94f7a5c6750
Autor:
Mateusz Rytelewski, Karine Harutyunyan, Natalia Baran, Saradhi Mallampati, M. Anna Zal, Antonio Cavazos, Jason M. Butler, Sergej Konoplev, Mirna El Khatib, Shane Plunkett, Joseph R. Marszalek, Michael Andreeff, Tomasz Zal, Marina Konopleva
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Abnormally low level of interstitial oxygen, or hypoxia, is a hallmark of tumor microenvironment and a known promoter of cancer chemoresistance. Inside a solid tumor mass, the hypoxia stems largely from inadequate supply of oxygenated blood through s
Externí odkaz:
https://doaj.org/article/04b6ea0b0f514755b3a0d14df43854f4
Autor:
Ana G Freire, Jason M Butler
Publikováno v:
F1000Research, Vol 9 (2020)
The generation of hematopoietic stem cells (HSCs) from pluripotent stem cell (PSC) sources is a long-standing goal that will require a comprehensive understanding of the molecular and cellular factors that determine HSC fate during embryogenesis. A p
Externí odkaz:
https://doaj.org/article/e3db11d4df5d41d5bb65a492dea6256e
Autor:
Suranjit Mukherjee, Tuo Zhang, Lauretta A. Lacko, Lei Tan, Jenny Zhaoying Xiang, Jason M. Butler, Shuibing Chen
Publikováno v:
Stem Cell Research, Vol 30, Iss , Pp 12-21 (2018)
Interest in human brown fat as a novel therapeutic target to tackle the growing obesity and diabetes epidemic has increased dramatically in recent years. While much insight into brown fat biology has been gained from murine cell lines and models, few
Externí odkaz:
https://doaj.org/article/b80c6ebffcd6487284c5e0192f36ea58
Autor:
Bowen Xu, Ling Cai, Jason M. Butler, Dongliang Chen, Xiongdong Lu, David F. Allison, Rui Lu, Shahin Rafii, Joel S. Parker, Deyou Zheng, Gang Greg Wang
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 675-683 (2018)
Summary: Self-renewal and differentiation of adult stem cells are tightly regulated partly through configuration of chromatin structure by chromatin remodelers. Using knockout mice, we here demonstrate that bromodomain PHD finger transcription factor
Externí odkaz:
https://doaj.org/article/68b649dbacad4069b98f371a76ed6495
Autor:
Martin Dreyling, Michael Dickinson, Joaquin Martinez Lopez, Arne Kolstad, Jason P Butler, Monalisa Ghosh, Leslie L. Popplewell, Julio Chavez, Emmanuel Bachy, Koji Kato, Hideo Harigae, Marie Jose Kersten, Charalambos Andreadis, Peter A. Riedell, Phoebe Joy Ho, Jose A. Perez-Simon, Andy Chen, Loretta J. Nastoupil, Bastian von Tresckow, Andrés J M Ferreri, Takanori Teshima, Piers E.M. Patten, Joseph P. McGuirk, Andreas Petzer, Fritz Offner, Andreas Viardot, Pier Luigi Zinzani, Ram Malladi, Ines Paule, Aiesha Zia, Rakesh Awasthi, Xia Han, Davide Germano, Darragh O'Donovan, Roberto Ramos, Aisha Masood, Catherine Thieblemont, Nathan H. Fowler, Stephen J. Schuster
Publikováno v:
Blood. 140:1459-1463
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::548dc2e074aaccf8ffbf7c72c3a598cb
https://doi.org/10.1182/blood-2022-158024
https://doi.org/10.1182/blood-2022-158024