Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jason A. Belsky"'
Autor:
Ishara F Azmi, Shinya Watanabe, Michael F Maloney, Sukhyun Kang, Jason A Belsky, David M MacAlpine, Craig L Peterson, Stephen P Bell
Publikováno v:
eLife, Vol 6 (2017)
Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initia
Externí odkaz:
https://doaj.org/article/521e37a5772a4be499b9d91e1175b534
Autor:
David M. MacAlpine, Joseph A. Prinz, Sara K. Powell, Heather K. MacAlpine, Yulong Li, Jason A. Belsky
Publikováno v:
The EMBO Journal. 34:531-543
Eukaryotic replication origins are defined by the ORC-dependent loading of the Mcm2-7 helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2-7 relative to ORC assembled onto chromatin in G1. These excess Mcm2-7 complexes
Autor:
Benjamin L. Lampson, David M. MacAlpine, Christopher M. Counter, Jason A. Belsky, Erin Kaltenbrun, Nicole L.K. Pershing
Publikováno v:
Journal of Clinical Investigation. 125:222-233
The KRAS gene is commonly mutated in human cancers, rendering the encoded small GTPase constitutively active and oncogenic. This gene has the unusual feature of being enriched for rare codons, which limit protein expression. Here, to determine the ef
Autor:
Craig L. Peterson, Stephen P. Bell, Sukhyun Kang, Shinya Watanabe, Ishara F. Azmi, Michael F. Maloney, David M. MacAlpine, Jason A. Belsky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72c83ab2486c43d304c13a779ece93a4
https://doi.org/10.7554/elife.22512.030
https://doi.org/10.7554/elife.22512.030
Autor:
Matthew L. Eaton, Shuqi Li, Jason A. Belsky, Hui Zhou, Qing Li, Jianxun Feng, Zhiguo Zhang, David M. MacAlpine, Haiyun Gan
Publikováno v:
Molecular and cellular biology. 36(13)
FACT (facilitates chromatin transcription) consists of two essential subunits, Spt16 and Pob3, and functions as a histone chaperone. Mutation of spt16 results in a global loss of nucleosomes as well as aberrant transcription. Here, we show that the m
Publikováno v:
Proceedings of the National Academy of Sciences. 108:18318-18323
We have combined standard micrococcal nuclease (MNase) digestion of nuclei with a modified protocol for constructing paired-end DNA sequencing libraries to map both nucleosomes and subnucleosome-sized particles at single base-pair resolution througho
Autor:
David M. MacAlpine, Heather K. MacAlpine, Yoav Lubelsky, Jason A. Belsky, Alexander J. Hartemink
Start sites of DNA replication are marked by the origin recognition complex (ORC), which coordinates Mcm2–7 helicase loading to form the prereplicative complex (pre-RC). Although pre-RC assembly is well characterized in vitro, the process is poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1919c573f1606f222c9a0de07b26afb1
https://europepmc.org/articles/PMC4298139/
https://europepmc.org/articles/PMC4298139/
Autor:
Thea A. Egelhofer, Maxwell W. Libbrecht, Michael M. Hoffman, Ju Han Kim, David M. MacAlpine, William Stafford Noble, Charles B. Epstein, Alex Appert, Q. Brent Chen, Michael J. Pazin, Peter J. Park, Manolis Kellis, Aki Minoda, Sheng'en Shawn Hu, Moritz Herrmann, Chitra V. Kotwaliwale, Jason A. Belsky, Jason D. Lieb, Susan Strome, Sasha A. Langley, Tingting Gu, Sevinc Ercan, Youngsook L. Jung, Kyung-Ah Sohn, Joshua W. K. Ho, Daniel He, Xikun Duan, Gary H. Karpen, Erica Larschan, Noam Shoresh, Isabel J. Latorre, Tao Liu, Bradley E. Bernstein, Bo Qin, Artyom A. Alekseyenko, Ron A.-J. Chen, Nicole C. Riddle, Przemyslaw Stempor, A. Vielle, Jacob M. Garrigues, Andreas Rechtsteiner, Huiling Xue, Tess E. Jeffers, Xiaole Shirley Liu, Burak H. Alver, Sarah K. Bowman, Anshul Kundaje, Stephen C. J. Parker, Peter V. Kharchenko, Soohyun Lee, Richard W. Park, Kohta Ikegami, Elise A. Feingold, Julie Ahringer, Psalm Haseley, Annette Plachetka, P. Kolasinska-Zwierz, Sarah C. R. Elgin, Vincenzo Pirrotta, Abby F. Dernburg, Eric Bishop, Yan Dong, Peter J. Good, Michael Y. Tolstorukov, Francesco Ferrari, Thomas D. Tullius, Xueqiu Lin, Yuri B. Schwartz, Chengyang Wang, Daniel S. Day, Dalal Asker, Andréa C. Dosé, Nischay Kumar, Christina M. Whittle, Robert E. Kingston, Nils Gehlenborg, Mitzi I. Kuroda, Hoang N. Pham
Publikováno v:
Nature, vol 512, iss 7515
Nature
Nature
Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25214de76e78b67a2ecafcb1e36b0481
https://escholarship.org/uc/item/6f66s6x2
https://escholarship.org/uc/item/6f66s6x2
Autor:
Yulong Li, David M. MacAlpine, Jason A. Belsky, Joseph A. Prinz, Leyna DeNapoli, Yoav Lubelsky
DNA replication is a dynamic process that occurs in a temporal order along each of the chromosomes. A consequence of the temporally coordinated activation of replication origins is the establishment of broad domains (>100 kb) that replicate either ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4788a5d9bae57e23e9cc6ea4d0ad5da9
https://europepmc.org/articles/PMC4079966/
https://europepmc.org/articles/PMC4079966/