Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jason A, Regules"'
Autor:
Jessica S. Bolton, Randall S. MacGill, Emily Locke, Jason A. Regules, Elke S. Bergmann-Leitner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPre-erythrocytic malaria vaccines hold the promise of inducing sterile protection thereby preventing the morbidity and mortality associated with Plasmodium infection. The main surface antigen of P. falciparum sporozoites, i.e., the circum
Externí odkaz:
https://doaj.org/article/0ade5144f61c4c5a99b1bb4130173d62
Autor:
Mark D. Langowski, Farhat A. Khan, Sofya Savransky, Dallas R. Brown, Arasu Balasubramaniyam, William B. Harrison, Xiaoyan Zou, Zoltan Beck, Gary R. Matyas, Jason A. Regules, Robin Miller, Lorraine A. Soisson, Adrian H. Batchelor, Sheetij Dutta
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract The Circumsporozoite Protein (CSP) of Plasmodium falciparum contains an N-terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major (NPNA) and minor repeats followed by a C-terminal domain. The recently approve
Externí odkaz:
https://doaj.org/article/0da9d7df686a4d03baf0a5d54ff2c7f7
Autor:
Nathan Beutler, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Randall S MacGill, Elijah Garcia, Jaeson Calla, Mara Parren, Linlin Yang, Wayne Volkmuth, Emily Locke, Jason A Regules, Sheetij Dutta, Daniel Emerling, Angela M Early, Daniel E Neafsey, Elizabeth A Winzeler, C Richter King, Fidel Zavala, Dennis R Burton, Ian A Wilson, Thomas F Rogers
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010409 (2022)
Potent and durable vaccine responses will be required for control of malaria caused by Plasmodium falciparum (Pf). RTS,S/AS01 is the first, and to date, the only vaccine that has demonstrated significant reduction of clinical and severe malaria in en
Externí odkaz:
https://doaj.org/article/466c773f347b462fb6e06036904736dc
Autor:
William Chad Young, Lindsay N. Carpp, Sidhartha Chaudhury, Jason A. Regules, Elke S. Bergmann-Leitner, Christian Ockenhouse, Ulrike Wille-Reece, Allan C. deCamp, Ellis Hughes, Celia Mahoney, Suresh Pallikkuth, Savita Pahwa, S. Moses Dennison, Sarah V. Mudrak, S. Munir Alam, Kelly E. Seaton, Rachel L. Spreng, Jon Fallon, Ashlin Michell, Fernando Ulloa-Montoya, Margherita Coccia, Erik Jongert, Galit Alter, Georgia D. Tomaras, Raphael Gottardo
Publikováno v:
Frontiers in Big Data, Vol 4 (2021)
RTS,S/AS01 (GSK) is the world’s first malaria vaccine. However, despite initial efficacy of almost 70% over the first 6 months of follow-up, efficacy waned over time. A deeper understanding of the immune features that contribute to RTS,S/AS01-media
Externí odkaz:
https://doaj.org/article/3a278326c7e94b59825dbc56352b388d
Autor:
Sidhartha Chaudhury, Jack Hutter, Jessica S Bolton, Shilpa Hakre, Evelyn Mose, Amy Wooten, William O'Connell, Joseph Hudak, Shelly J Krebs, Janice M Darden, Jason A Regules, Clinton K Murray, Kayvon Modjarrad, Paul Scott, Sheila Peel, Elke S Bergmann-Leitner
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252628 (2021)
Serological assessment of SARS-CoV-2 specific responses are an essential tool for determining the prevalence of past SARS-CoV-2 infections in the population especially when testing occurs after symptoms have developed and limited contact tracing is i
Externí odkaz:
https://doaj.org/article/3b8a19a2f28c4c5ba6f8ec00eed61395
Autor:
Ying Du, Ethan G. Thompson, Julius Muller, Joseph Valvo, Jackie Braun, Smitha Shankar, Robert A. van den Berg, Erik Jongert, Drew Dover, Jerald Sadoff, Jenny Hendriks, Malcolm J. Gardner, W. Ripley Ballou, Jason A. Regules, Robbert van der Most, Alan Aderem, Christian F. Ockenhouse, Adrian V. Hill, Ulrike Wille-Reece, Daniel E. Zak
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The RTS,S/AS01 vaccine provides partial protection against Plasmodium falciparum infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associ
Externí odkaz:
https://doaj.org/article/7307d7b8880a4c2faaa0b56834a30238
Autor:
Sidhartha Chaudhury, Jason A. Regules, Christian A. Darko, Sheetij Dutta, Anders Wallqvist, Norman C. Waters, Erik Jongert, Franck Lemiale, Elke S. Bergmann-Leitner
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract A recent study of the RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase in efficacy from 50–60% to 80% when using a delayed fractional dose regimen, in which the standard 0–1–2 month
Externí odkaz:
https://doaj.org/article/da43572f2ab14d5da906e3ca77074fd9
Autor:
Kristopher M, Paolino, Jason A, Regules, James E, Moon, Richard C, Ruck, Jason W, Bennett, Shon A, Remich, Kristin T, Mills, Leyi, Lin, Cadeidre N, Washington, Ghariwayne A, Fornillos, Changhong Y, Lindsey, Kristan A, O'Brien, Meng, Shi, R, Mark Jones, Brian J, Green, Stephen, Tottey, Jessica A, Chichester, Stephen J, Streatfield, Vidadi, Yusibov
Publikováno v:
Vaccine. 40:1864-1871
The potential use of Bacillus anthracis as a bioterrorism weapon requires a safe and effective vaccine that can be immediately distributed for mass vaccination. Protective antigen (PA), a principal component of virulence factors edema toxin and letha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe3a4cfd8259275aee5d7324600c5a2
https://doi.org/10.1016/j.vaccine.2022.01.047
https://doi.org/10.1016/j.vaccine.2022.01.047
Autor:
James E, Moon, Christian, Ockenhouse, Jason A, Regules, Johan, Vekemans, Cynthia, Lee, Ilin, Chuang, Magali, Traskine, Erik, Jongert, Karen, Ivinson, Danielle, Morelle, Jack L, Komisar, Marc, Lievens, Martha, Sedegah, Lindsey S, Garver, April K, Sikaffy, Norman C, Waters, William Ripley, Ballou, Opokua, Ofori-Anyinam, Linda, Murray
Publikováno v:
The Journal of Infectious Diseases
Background A previous RTS,S/AS01B vaccine challenge trial demonstrated that a 3-dose (0-1-7–month) regimen with a fractional third dose can produce high vaccine efficacy (VE) in adults challenged 3 weeks after vaccination. This study explored the V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8469f62f402d7500db38f274e675fb01
https://doi.org/10.1093/infdis/jiaa421
https://doi.org/10.1093/infdis/jiaa421
Autor:
Sidhartha Chaudhury, Jessica S. Bolton, Leigh Anne Eller, Merlin Robb, Julie Ake, Viseth Ngauy, Jason A. Regules, Edwin Kamau, Elke S. Bergmann-Leitner
Publikováno v:
Journal of Clinical Medicine; Volume 11; Issue 7; Pages: 1839
Reliably assessing exposure to mosquitoes carrying malaria parasites continues to be a challenge due to the lack of reliable, highly sensitive diagnostics with high-throughput potential. Here, we describe an approach that meets these requirements by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f224cbfe5c11816cde93e504f6def94