Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jason, Younkin"'
Autor:
Alaina M, Jaster, Jason, Younkin, Travis, Cuddy, Mario, de la Fuente Revenga, Justin L, Poklis, Mikhail G, Dozmorov, Javier, González-Maeso
Publikováno v:
Neurosci Lett
Psychedelics, also known as classical hallucinogens, affect processes related to perception, cognition and sensory processing mostly via the serotonin 5-HT(2A) receptor (5-HT(2A)R). This class of psychoactive substances, which includes lysergic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3be76837db27fe9d89c9cdf3a7ad4cb
https://pubmed.ncbi.nlm.nih.gov/35963476
https://pubmed.ncbi.nlm.nih.gov/35963476
Autor:
Alaina M. Jaster, Jason Younkin, Travis Cuddy, Mario de la Fuente Revenga, Justin L. Poklis, Mikhail G. Dozmorov, Javier González-Maeso
Publikováno v:
Neuroscience Letters. 788:136836
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f38ea57ed8713e21ae108648ca84352d
https://doi.org/10.1016/j.neulet.2022.136836
https://doi.org/10.1016/j.neulet.2022.136836
Autor:
Kelsey S. Hideshima, Diomedes E. Logothetis, Jose M. Eltit, Jason Younkin, Lia Baki, Amr Ellaithy, Supriya A Gaitonde, Javier González-Maeso, Malgorzata Dukat, José L. Moreno, Rakesh H. Vekariya, Sneha Shah, Richard A. Glennon, Peter Drossopoulos
Publikováno v:
ACS Chemical Neuroscience. 7:1292-1299
Several pharmacophore models have been proposed for 5-HT2A serotonin receptor antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a given distance from each other, and from a basic amine. Although specified distance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c757905d6e4c7182d21979a6df29b4
https://doi.org/10.1021/acschemneuro.6b00162
https://doi.org/10.1021/acschemneuro.6b00162
Autor:
Javier González-Maeso, José L. Moreno, Jason Younkin, Lia Baki, Jose M. Eltit, Adishesh Narahari, Diomedes E. Logothetis, Zhanna V. Vysotskaya, Stuart C. Sealfon, Miguel Fribourg, Gyu Park
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:775-793
We previously reported that co-expression of the Gi-coupled metabotropic glutamate receptor 2 (mGlu2R) and the Gq-coupled serotonin (5-HT) 2A receptor (2AR) in Xenopus oocytes (Fribourg et al. Cell 147:1011-1023, 2011) results in inverse cross-signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281dc459f362c72ae7a99270ed4d06ce
https://doi.org/10.1007/s00424-015-1780-7
https://doi.org/10.1007/s00424-015-1780-7
Autor:
Hailin Zhang, Jason Younkin, Guoqing Xiang, George Liapakis, Katerina Spyridaki, Meng Cui, Miguel Fribourg, Amr Ellaithy, Candice Hatcher-Solis, Javier González-Maeso, Diomedes E. Logothetis
Publikováno v:
Current Pharmaceutical Biotechnology. 15:987-995
Kir3 (or GIRK) channels have been known for nearly three decades to be activated by direct interactions with the βγ subunits of heterotrimeric G (Gαβγ) proteins in a membrane-delimited manner. Gα also interacts with GIRK channels and since PTX-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4b97e9437e1dbd8fee7cacee7b2fc1
https://doi.org/10.2174/1389201015666141031111916
https://doi.org/10.2174/1389201015666141031111916
Autor:
Graeme Milligan, Patricia Miranda-Azpiazu, Anastasios Georgakopoulos, Meng Cui, Ariel Ben-Ezra, Georgios Voloudakis, Nikolaos K. Robakis, Diomedes E. Logothetis, Aintzane García-Bea, Juan F. López-Giménez, Alexey Kozlenkov, Lia Baki, Javier González-Maeso, Jason Younkin, Yongchao Ge, José L. Moreno, Amanda K. Fakira, Jose A. Morón, J. Javier Meana
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
PMCID: PMC4819166.-- Moreno et al.
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) can form multiprotein complexes (heteromers), which can alter the pharmacology and functions of the constituent receptors.
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) can form multiprotein complexes (heteromers), which can alter the pharmacology and functions of the constituent receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870a4b456ac480c71abf6a58f578a748
https://europepmc.org/articles/PMC4819166/
https://europepmc.org/articles/PMC4819166/
Publikováno v:
Trends in neurosciences. 38(8)
The past two decades have witnessed a rise in the ‘NMDA receptor hypofunction’ hypothesis for schizophrenia, a devastating disorder that affects around 1% of the population worldwide. A variety of presynaptic, postsynaptic, and regulatory protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fa4475bfc0a659f5856bf1d2b886d5
https://pubmed.ncbi.nlm.nih.gov/26148747
https://pubmed.ncbi.nlm.nih.gov/26148747
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfdb390610e63a7cdac61a6bb17b5236
https://doi.org/10.1096/fasebj.26.1_supplement.660.12
https://doi.org/10.1096/fasebj.26.1_supplement.660.12
Autor:
Zhanna V. Vysotskaya, Miguel Fribourg, Gyu Park, Amr Ellaithy, Jason Younkin, Jose M. Eltit, Diomedes E. Logothetis, Lia Baki
Publikováno v:
Biophysical Journal. 108:416a
Atypical antipsychotic drugs targeting the 5-HT2A receptor (2AR) are widely used in the treatment of schizophrenia and psychosis. Recent studies point to a new class of potential antipsychotic drugs targeting the metabotropic glutamate receptor 2 (mG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9814699c5dcf21eb00da0a614c2dd3
https://doi.org/10.1016/j.bpj.2014.11.2280
https://doi.org/10.1016/j.bpj.2014.11.2280
Publikováno v:
Biophysical Journal. 108:416a
Atypical antipsychotic drugs targeting the Gq-coupled serotonin 5-HT2A receptor (2AR) are widely used in the treatment of schizophrenia, whereas recent studies point to a new class of potential antipsychotic drugs targeting the Gi-coupled metabotropi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acabc34f48a2395868554de357bede8
https://doi.org/10.1016/j.bpj.2014.11.2281
https://doi.org/10.1016/j.bpj.2014.11.2281