Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jason, Howitt"'
Autor:
Mayura V. Wagle, Julia M. Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C. Goodnow, Ian A. Parish
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 577-584 (2018)
Summary: Escape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin li
Externí odkaz:
https://doaj.org/article/f1df04bb8c3940ffbd9e365a5f64deff
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3452 (2020)
Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic drivers on the immune response, as well as their value as targets for immunotherapy. At the heart of tumour suppression
Externí odkaz:
https://doaj.org/article/86a1686378f745179a81fcc593bce7ec
Publikováno v:
Aging Cell. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45902c5b0e6c653a39562766a7393fa4
https://doi.org/10.1111/acel.13647
https://doi.org/10.1111/acel.13647
Publikováno v:
Aging cell. 21(7)
Aging is associated with a loss of metabolic homeostasis, with cofactors such as nicotinamide adenine dinucleotide (NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbcf78402858b19b2180b0e40f03a337
https://pubmed.ncbi.nlm.nih.gov/35661560
https://pubmed.ncbi.nlm.nih.gov/35661560
Autor:
Michelle Tang, Aleksandra Bankovacki, Samuel N. Young, Che A. Stafford, Sarah E Garnish, Joanne M Hildebrand, Ueli Nachbur, Cheree Fitzgibbon, Kristy Shield-Artin, John Silke, James M. Murphy, Zikou Liu, Jason Howitt, Andrew I. Webb, David Komander, Xiangyi Wang, Laura F. Dagley
Publikováno v:
EMBO J
Mixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c739544cf793f6111dd7795de02925
https://doi.org/10.15252/embj.2019103718
https://doi.org/10.15252/embj.2019103718
Autor:
Jason Howitt, Amanda M Gysbers, Scott Ayton, Francine Carew-Jones, Ulrich Putz, David I Finkelstein, Glenda M Halliday, Seong-Seng Tan
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87119 (2014)
Iron misregulation is a central component in the neuropathology of Parkinson's disease. The iron transport protein DMT1 is known to be increased in Parkinson's brains linking functional transport mechanisms with iron accumulation. The regulation of D
Externí odkaz:
https://doaj.org/article/767b3a60127b4941bb2af571c32d443e
Autor:
Cheree Fitzgibbon, James M. Murphy, Jason Howitt, Samuel N. Young, Xiangyi Wang, Zikou Liu, Ueli Nachbur, Laura F. Dagley, David Komander, Michelle Tang, Aleksandra Bankovacki, Andrew I. Webb, Che A. Stafford, John Silke, Joanne M Hildebrand, Sarah E Garnish, Kristy Shield-Artin
Mixed lineage kinase domain-like (MLKL) is the executioner in the caspase-independent form of programmed cell death called necroptosis. Receptor Interacting serine/threonine Protein Kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff9e3cb7c2fc3ceb3bfc78d1147aeb38
https://doi.org/10.1101/2021.05.01.442209
https://doi.org/10.1101/2021.05.01.442209
Autor:
Alex, Mazurskyy, Jason, Howitt
Publikováno v:
Sub-cellular biochemistry. 97
The role of extracellular vesicles (EVs) in the central nervous system, and in particular the brain, is a rapidly growing research area. Importantly, the role for EVs in the nervous system spans from early development through to old age, with EVs bei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad1382085b35cfc23701027786d28996
https://pubmed.ncbi.nlm.nih.gov/33779926
https://pubmed.ncbi.nlm.nih.gov/33779926
Autor:
Alex Mazurskyy, Jason Howitt
Publikováno v:
Subcellular Biochemistry ISBN: 9783030671709
The role of extracellular vesicles (EVs) in the central nervous system, and in particular the brain, is a rapidly growing research area. Importantly, the role for EVs in the nervous system spans from early development through to old age, with EVs bei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3db9b050263d8fc93132debdd3148417
https://doi.org/10.1007/978-3-030-67171-6_16
https://doi.org/10.1007/978-3-030-67171-6_16
Autor:
Jason Howitt, Ian A. Parish, Christopher C. Goodnow, Seong-Seng Tan, Julia M. Marchingo, Mayura V Wagle
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 577-584 (2018)
Summary: Escape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4da1302d96aebb468dff9fc7ffc9b53
https://doi.org/10.1016/j.celrep.2018.06.060
https://doi.org/10.1016/j.celrep.2018.06.060