Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jason, Cassaday"'
Autor:
Stephen H. Kasper, Stephanie Otten, Brian Squadroni, Cionna Orr‐Terry, Yi Kuang, Lily Mussallem, Lan Ge, Lin Yan, Srinivasaraghavan Kannan, Chandra S. Verma, Christopher J. Brown, Charles W. Johannes, David P. Lane, Arun Chandramohan, Anthony W. Partridge, Lee R. Roberts, Hubert Josien, Alex G. Therien, Erik C. Hett, Bonnie J. Howell, Andrea Peier, Xi Ai, Jason Cassaday
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 5, Pp n/a-n/a (2023)
Abstract Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have
Externí odkaz:
https://doaj.org/article/4ede5586001347c2a4d447e4b2a014ec
Autor:
Jiajie Wei, Scott Radcliffe, Amanda Pirrone, Meiqing Lu, Yuan Li, Jason Cassaday, William Newhard, Gwendolyn J. Heidecker, William A. Rose II, Xi He, Daniel Freed, Michael Citron, Amy Espeseth, Dai Wang
Publikováno v:
Viruses, Vol 15, Iss 10, p 2034 (2023)
Despite the success of rotavirus vaccines, rotaviruses remain one of the leading causes of diarrheal diseases, resulting in significant childhood morbidity and mortality, especially in low- and middle-income countries. The reverse genetics system ena
Externí odkaz:
https://doaj.org/article/491cba653e574a2d85c2b488220ee08b
Autor:
null Stephen H. Kasper, null Stephanie Otten, null Brian Squadroni, null Cionna Orr‐Terry, null Yi Kuang, null Lily Mussallem, null Lan Ge, null Lin Yan, null Srinivasaraghavan Kannan, null Chandra S. Verma, null Christopher J. Brown, null Charles W. Johannes, null David P. Lane, null Arun Chandramohan, null Anthony W. Partridge, null Lee R. Roberts, null Hubert Josien, null Alex G. Therien, null Erik C. Hett, null Bonnie J. Howell, null Andrea Peier, null Xi Ai, null Jason Cassaday
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a3660365f9c9945a524ebfb3f98bc0
https://doi.org/10.1002/btm2.10542/v2/response1
https://doi.org/10.1002/btm2.10542/v2/response1
Autor:
Brian Squadroni, William Newhard, Donna Carr, Huong Trinh, Fred Racine, Paul Zuck, Bonnie Howell, Daria J. Hazuda, Jason Cassaday
Publikováno v:
SLAS technology. 27(4)
Dynamic in vitro antibacterial studies provide valuable insight on effective dosing strategies prior to translating to in vivo models. Frequent sampling is required to monitor the pharmacodynamics (PD) of these studies, leading to significant work wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb57c4f2d687295dd99dd7a13dcc1bc9
https://pubmed.ncbi.nlm.nih.gov/35367399
https://pubmed.ncbi.nlm.nih.gov/35367399
Autor:
Jian Liu, Brian Squadroni, Bonnie J. Howell, Paul Zuck, Wensheng Yu, Daria J. Hazuda, Joe Kozlowski, Jeanine E. Ballard, Ryan C. Vargo, Richard J. O. Barnard, Jason Cassaday, Guoxin Wu, Munjal Patel, William Newhard
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(5)
Antiretroviral therapy is able to effectively control but not eradicate HIV infection, which can persist, leading to the need for lifelong therapy. The existence of latently HIV-infected cells is a major barrier to the eradication of chronic HIV infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6796f1335c27c8423ccf8769b32223
https://pubmed.ncbi.nlm.nih.gov/33427012
https://pubmed.ncbi.nlm.nih.gov/33427012
Autor:
Elisabeth MacColl, Paul Zuck, Victor N. Uebele, Michelle F Homsher, Jeffrey D. Hermes, Jason Cassaday, Jennifer Nothstein
Publikováno v:
SLAS Technology. 22:485-492
Automated mechanism of action studies are introducing the need for tailored compound delivery, which can be challenging for standard compound management procedures. Jump dilution assays investigating inhibitor reversibility require compound delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956e7b3fb6d3ae7591d1a0972d3e9c2e
https://doi.org/10.1177/2472630316684807
https://doi.org/10.1177/2472630316684807
Autor:
Douglas C. Beshore, Stephen Day, Jason Cassaday, Michelle F. Homsher, Brian Squadroni, David Pechter, Michelle Smith, Lei Ma, Jeffrey D. Hermes, Elizabeth Mohammed, Michelle Hartnett, Paul Zuck, Michael F.A. Finley, Victor N. Uebele, Fredrick Monsma
Publikováno v:
SLAS Discovery. 22:1060-1066
Agonist shift assays feature cross-titrations of allosteric modulators and orthosteric ligands. Information generated in agonist shift assays can include a modulator's effect on the orthosteric agonist's potency (alpha) and efficacy (beta), as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aa4a57a20f8bcde2680cb5a7bfd7c52
https://doi.org/10.1177/2472555217705373
https://doi.org/10.1177/2472555217705373
Autor:
Bharti Gajera, Albert Rauch, Paul Zuck, Sylvie Jezequel-Sur, Michael F.A. Finley, Jason Cassaday, Jeffrey D. Hermes, Victor N. Uebele, Brian Squadroni
Publikováno v:
SLAS Technology. 22:195-205
In the triage of hits from a high-throughput screening campaign or during the optimization of a lead compound, it is relatively routine to test compounds at multiple concentrations to determine potency and maximal effect. Additional follow-up experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061a421fab1301d8c06fa8e561b2e973
https://doi.org/10.1177/2211068216679805
https://doi.org/10.1177/2211068216679805
Autor:
Michelle F, Homsher, Douglas C, Beshore, Jason, Cassaday, Brian, Squadroni, Elizabeth, Mohammed, Michelle, Hartnett, Stephen, Day, Lei, Ma, David, Pechter, Michelle D, Smith, Fredrick, Monsma, Paul, Zuck, Michael F, Finley, Victor N, Uebele, Jeffrey D, Hermes
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(8)
Agonist shift assays feature cross-titrations of allosteric modulators and orthosteric ligands. Information generated in agonist shift assays can include a modulator's effect on the orthosteric agonist's potency (alpha) and efficacy (beta), as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7c79a7b5f4df8eb76db0b4627102a9f
https://pubmed.ncbi.nlm.nih.gov/28426939
https://pubmed.ncbi.nlm.nih.gov/28426939
Autor:
Kelly-Ann S. Schlegel, Peter S. Kutchukian, Lee Warren, Sophie Parmentier-Batteur, Jason Cassaday, Victor N. Uebele, Brian C. Magliaro, Brian Squadroni, Danielle M. Hurzy, Eric N. Johnson, J. Chris Culberson, Gregory O'Donnell, Adam Amoss, Fiona Thomson, Michael F.A. Finley, Paul Zuck, Andrew J. Cooke, Danette Pascarella, Jeffrey D. Hermes
N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ee89032dec0bd4c1bf64d0fea584c0
https://eprints.gla.ac.uk/146530/1/146530.pdf
https://eprints.gla.ac.uk/146530/1/146530.pdf