Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jason, Breed"'
Autor:
Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Mutant RAS family members occur in a wide range of tumour types, and there is a great interest in identifying isoform-specific inhibitors. Here, the authors characterise two designed ankyrin repeat proteins (DARPins) that specifically inhibit the KRA
Externí odkaz:
https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd
Autor:
James S. Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J. Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R. J. Davey, David I. Fisher, Eric T. Gangl, Tyler Grebe, Ryan D. Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J. Hughes, Thomas A. Hunt, Tony Johnson, Stefan L. Kavanagh, Teresa C. M. Klinowska, Carrie J. B. Larner, Mandy Lawson, Andrew S. Lister, David Longmire, Stacey Marden, Thomas M. McGuire, Caroline McMillan, Lindsay McMurray, Christopher J. Morrow, J. Willem M. Nissink, Thomas A. Moss, Daniel H. O’Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J. Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Publikováno v:
Journal of Medicinal Chemistry. 66:2918-2945
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ec7d4c4fb73ee3f4aed9c21a77b1bf
https://doi.org/10.1021/acs.jmedchem.2c01964
https://doi.org/10.1021/acs.jmedchem.2c01964
Autor:
Sandrine Guillard, Paulina Kolasinska-Zwierz, Judit Debreczeni, Jason Breed, Jing Zhang, Nicolas Bery, Rose Marwood, Jon Tart, Ross Overman, Pawel Stocki, Bina Mistry, Christopher Phillips, Terence Rabbitts, Ronald Jackson, Ralph Minter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great efforts. Here the authors structurally and functionally characterize a DARPin that potently inhibits the nucleotide exchange of Ras, which might facilit
Externí odkaz:
https://doaj.org/article/511b9c0f118d47a5b8dc1ab52f044f6e
Autor:
Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Michael S. Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J. Carbajo, Doyle J. Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L. Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J. Lewis, Libin Liu, Michael J. Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme Robb, David M. Robinson, Sarah Ross, Matthew G. Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:6940-6952
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb2a4d859543d18252213a2d5a9b54c
https://doi.org/10.1021/acs.jmedchem.2c00369
https://doi.org/10.1021/acs.jmedchem.2c00369
Autor:
Guy Nimrod, Sharon Fischman, Mark Austin, Asael Herman, Feenagh Keyes, Olga Leiderman, David Hargreaves, Marek Strajbl, Jason Breed, Shelley Klompus, Kevin Minton, Jennifer Spooner, Andrew Buchanan, Tristan J. Vaughan, Yanay Ofran
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2121-2131.e5 (2018)
Summary: The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by focusing on functional epitopes, integrating large-scale statistical analysis with multip
Externí odkaz:
https://doaj.org/article/e21b3c7b86a74d50adb9bf3461cc5156
Autor:
Roger Castells-Graells, Kyle Meador, Mark A. Arbing, Michael R. Sawaya, Morgan Gee, Duilio Cascio, Emma Gleave, Judit É. Debreczeni, Jason Breed, Chris Phillips, Todd O. Yeates
Numerous technical advances have made cryo-EM an attractive method for atomic structure determination. Cryo-EM is ideally suited for large macromolecular structures, while problems of low signal-to-noise prevent routine structure determination of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66a660e313b807d2de9725cea7726274
https://doi.org/10.1101/2022.09.18.508009
https://doi.org/10.1101/2022.09.18.508009
Autor:
J Willem M Nissink, Michal Bista, Jason Breed, Nikki Carter, Kevin Embrey, Jonathan Read, Jon J Winter-Holt
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151154 (2016)
MTH1 (NUDT1) is an oncologic target involved in the prevention of DNA damage. We investigate the way MTH1 recognises its substrates and present substrate-bound structures of MTH1 for 8-oxo-dGTP and 8-oxo-rATP as examples of novel strong and weak bind
Externí odkaz:
https://doaj.org/article/9fb8b358bc4f48ecb81ceedb4cb0f8a9
Autor:
Rodrigo J. Carbajo, S. Harlfinger, Lyman Feron, Jason Grant Kettle, E.S. Gleave, Hilary J. Lewis, L. Liu, A. Jackson, Doyle Joseph Cassar, Sharanjeet Kaur Bagal, David Robinson, Radoslaw Polanski, L. Zhang, M.R. Howard, Sabina Cosulich, L. Evans, Jason Breed, Graeme R. Robb, A. Chakraborty, Rachel L. Howells, Rebecca Whiteley, Scott G. Lamont, Lyndsey Hanson, J.K. Kingston, Michael Davies, Iain A. Cumming, Sarah Ross, Sue Bickerton, Paul D. Kemmitt, Derek Ogg, Andrew John Eatherton, James M. Smith, S. Li, Bodnarchuk, Frederick W. Goldberg, Christopher R. Phillips, X. Zhao, Jun Yang, Michael Tonge, Shaun M. Fillery
Publikováno v:
Journal of Medicinal Chemistry. 63:4468-4483
Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRASG12C mutant represents an "Achilles heel" and has recently yielded to covalent targeting with small mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c0d1227f159830cde7d87c48972047a
https://doi.org/10.1021/acs.jmedchem.9b01720
https://doi.org/10.1021/acs.jmedchem.9b01720
Autor:
Teresa Klinowska, J. Willem M. Nissink, Hoan K. Huynh, Jason Breed, Christopher J. Morrow, Paul R. J. Davey, Thomas A. Moss, Jeffrey G. Varnes, Rodrigo J. Carbajo, James S. Scott, Bin Yang, Radoslaw Polanski, Ryan Greenwood
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the use of metathesis to construct a novel tetracyclic core in a series of estrogen receptor degraders. This improved the chemical stability, as assessed using an NMR-MS based assay, and gave a molecule with excelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f525834993e999069006af5d92eabab5
https://doi.org/10.1021/acsmedchemlett.9b00370
https://doi.org/10.1021/acsmedchemlett.9b00370
Autor:
Haixia Wang, Stefan Kavanagh, Radoslaw Polanski, Eric Gangl, Michael J. Tucker, Jason Breed, Thomas Anthony Hunt, Paul R. J. Davey, Mandy Lawson, Darren Stead, Oona Delpuech, Ye Wu, J. Willem M. Nissink, Barlaam Bernard Christophe, Dedong Wu, Sudhir M. Hande, Amber Balazs, Dermot F. McGinnity, Wenzhan Yang, Thomas A. Moss, Bin Yang, Sladjana Gagrica, Kumar Thakur, Stacey Marden, Tyler Grebe, Daniel Hillebrand O'donovan, Teresa Klinowska, Samantha Jayne Hughes, Kara Herlihy, David I Fisher, Stephen Stokes, Holia Hatoum-Mokdad, Tony Johnson, James S. Scott, Elisabetta Chiarparin, Bo Peng, Sophie L. M. Janbon, Scott Throner, Ryan Greenwood, David Matthew Wilson, Andrew Lister, Stephen Fawell, Hoan Huynh, Jeffrey G. Varnes, Christopher J. Morrow, Rodrigo J. Carbajo
Publikováno v:
Journal of medicinal chemistry. 63(23)
Herein we report the optimization of a series of tricyclic indazoles as selective estrogen receptor degraders (SERD) and antagonists for the treatment of ER+ breast cancer. Structure based design together with systematic investigation of each region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307a07ad198923d95942c131a39083de
https://pubmed.ncbi.nlm.nih.gov/32910656
https://pubmed.ncbi.nlm.nih.gov/32910656