Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jason, Aoto"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Proteins critical for synaptic transmission are non-uniformly distributed and assembled into regions of high density called subsynaptic densities (SSDs) that transsynaptically align in nanocolumns. Neurexin-1 and neurexin-3 are essential pre
Externí odkaz:
https://doaj.org/article/fa67ec0472b64f748f8dd41aede6d8f6
Autor:
Samantha S. Olah, Dean J. Kareemo, William C. Buchta, Brooke L. Sinnen, Carley N. Miller, Hannah S. Actor-Engel, Sara E. Gookin, Christina S. Winborn, Mason S. Kleinjan, Kevin C. Crosby, Jason Aoto, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113331- (2023)
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and postsynaptic elemen
Externí odkaz:
https://doaj.org/article/3444965cf8894b45b28692c79eca5faf
Autor:
Emma E. Boxer, Jason Aoto
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Since the discovery of neurexins (Nrxns) as essential and evolutionarily conserved synaptic adhesion molecules, focus has largely centered on their functional contributions to glutamatergic synapses. Recently, significant advances to our understandin
Externí odkaz:
https://doaj.org/article/b1409ae9a19845a7b0204006ba938b53
Autor:
Alicia M. Purkey, Kevin M. Woolfrey, Kevin C. Crosby, Dominik G. Stich, Wallace S. Chick, Jason Aoto, Mark L. Dell’Acqua
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 974-987.e4 (2018)
Summary: Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating CP-AMPARs are poorly
Externí odkaz:
https://doaj.org/article/5cfe45e1aa0144229d4b3260ef3ae995
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience.
Ventral subiculum (vSUB) is the major output region of ventral hippocampus (vHIPP) and sends major projections to nucleus accumbens medial shell (NAcMS). Hyperactivity of the vSUB-NAcMS circuit is associated with substance use disorders and the modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a309991428d1adc7a2195ee67d5efba
https://pubmed.ncbi.nlm.nih.gov/36609456
https://pubmed.ncbi.nlm.nih.gov/36609456
Publikováno v:
J Neurosci
Presynaptic α-neurexins are highly expressed and more frequently linked to neuropsychiatric and neurodevelopmental disorders than β-neurexins. However, how extracellular sequences specific to α-neurexins enable synaptic transmission is poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9863ee12ceff3f1f608a903147ad716
https://doi.org/10.1523/jneurosci.1261-19.2019
https://doi.org/10.1523/jneurosci.1261-19.2019
Autor:
Felicia Mermer, Kathryn Rigsby, Scott Demerast, Patrick S. McGrath, Jing-Qiong Kang, Jason Aoto, Dennis Lal, Gerald Nwosu, Ganna Bilousova, Anuj Rastogi, Wangzhen Shen, Alejandra I. Romero-Morales, Sarah Poliquin, Vivian Gama
Publikováno v:
Brain : a journal of neurology. 144(8)
Solute carrier family 6 member 1 (SLC6A1) is abundantly expressed in the developing brain even before the central nervous system is formed. Its encoded GABA transporter 1 is responsible for the reuptake of GABA into presynaptic neurons and glia, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599ba78fde5f38527c1b34284a0d85df
https://pubmed.ncbi.nlm.nih.gov/34283886
https://pubmed.ncbi.nlm.nih.gov/34283886
Publikováno v:
Journal of Visualized Experiments.
Protein interactions at cellular interfaces dictate a multitude of biological outcomes ranging from tissue development and cancer progression to synapse formation and maintenance. Many of these fundamental interactions occur in trans and are typicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f82e4af2e6704cbb5b208e898bcb224
https://doi.org/10.3791/61237
https://doi.org/10.3791/61237
Autor:
Aaron J. Norris, Michael R. Bruchas, Christina L. Wysoczynski, Jason Aoto, Chandra L. Tucker, Kyle Meador
Publikováno v:
Nucleic Acids Research
A common mechanism for inducibly controlling protein function relies on reconstitution of split protein fragments using chemical or light-induced dimerization domains. A protein is split into fragments that are inactive on their own, but can be recon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd000e38b256250396b713875c0e718
https://pubmed.ncbi.nlm.nih.gov/31287871
https://pubmed.ncbi.nlm.nih.gov/31287871
Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum
Autor:
Emma E. Boxer, Charlotte Seng, David Lukacsovich, JungMin Kim, Samantha Schwartz, Matthew J. Kennedy, Csaba Földy, Jason Aoto
Publikováno v:
Cell reports
SUMMARY Ventral subiculum (vSUB) is integral to the regulation of stress and reward; however, the intrinsic connectivity and synaptic properties of the inhibitory local circuit are poorly understood. Neurexin-3 (Nrxn3) is highly expressed in hippocam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01d5947134f5ba67fb24e0691da9a38
http://europepmc.org/articles/PMC8763380
http://europepmc.org/articles/PMC8763380