Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jasna Jerecic"'
ACU193: An Immunotherapeutic Poised to Test the Amyloid β Oligomer Hypothesis of Alzheimer’s Disease
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Alzheimer’s disease (AD) is an age-related neurodegenerative disease that affects 50 million people worldwide, with 10 million new cases occurring each year. The emotional and economic impacts of AD on patients and families are devastating. Approve
Externí odkaz:
https://doaj.org/article/4971a750ae7b43df80daa863a1f35673
Autor:
Erika N. Cline, Hugo Marcel Vanderstichele, Derrick Johnson, Sanofar Jainul Abdeen, Paul McDermott, James Cruse, Kirsten L. Viola, Robert A Dean, Jasna Jerecic
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Keran Ma, Inma Cobos, YueQiang Xue, Jasna Jerecic, Kaitlyn Ho, Jorge J. Palop, Jean-Cosme Dodart, Abdullah S. Khan, Maria M. Martinez-Losa
Publikováno v:
Alzheimer's & Dementia. 15:P595-P595
Autor:
Paul Acton, Sara J. Fernandez, Gene G. Kinney, Diana Wu, William L. Klein, Mary P. Lambert, Elizabeth Chen-Dodson, Paul J. Shughrue, Eileen H. Bigio, Jasna Jerecic, Fernanda G. De Felice, Pauline T. Velasco, Pascale N. Lacor
Publikováno v:
Neurobiology of Aging. 29:1334-1347
Alzheimer's disease (AD) is characterized by presence of extracellular fibrillar A beta in amyloid plaques, intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated tau and elevated brain levels of soluble A beta oligomers (
Autor:
Raymond Lowe, Jean-Claude R. Breach, Todd Pray, Michele McEntee, Hsiu-Mei Wu, Catherine M. Hironaka, Lily Ruslim-Litrus, Sue Zhang, David Summa, Susan M. Catalano, Gary C. Look, Jasna Jerecic, Walter J. Crosier, Lev Igoudin, Diana B. Cherbavaz, William F. Goure, Grant A. Krafft
Publikováno v:
Current Alzheimer Research. 4:562-567
Amyloid beta-derived diffusible ligands (ADDLs) comprise the neurotoxic subset of soluble Abeta(1-42) oligomers, now widely considered to be the molecular cause of memory malfunction and neurodegeneration in Alzheimer's disease (AD). We have develope
Autor:
Bradley T. Hyman, Daniel Kanmert, Tiernan T. O'Malley, Jasna Jerecic, Lynn R Zieske, Dennis J. Selkoe, Dominic M. Walsh, Ting Yang, Henrik Zetterberg
Publikováno v:
Alzheimer's Research & Therapy
Introduction Amyloid β-protein oligomers play a key role in Alzheimer’s disease (AD), but well-validated assays that routinely detect them in cerebrospinal fluid (CSF) are just emerging. We sought to confirm and extend a recent study using the Sin
Autor:
Rolf Sprengel, Peter Jonas, Jasna Jerecic, Josef Bischofberger, Christian H. Schulze, Peter H. Seeburg
Publikováno v:
Molecular Brain Research
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to arginine (R) substitution in a critical channel site at
Autor:
Franz Hefti, Patricia Ann Walicke, Jasna Jerecic, Grant A. Krafft, Kent S. Iverson, William F. Goure
Publikováno v:
Alzheimer's & Dementia. 9
Autor:
William F. Goure, Patricia Ann Walicke, Grant A. Krafft, Jasna Jerecic, Kent S. Iverson, Franz Hefti
Publikováno v:
Trends in pharmacological sciences. 34(5)
Soluble Aβ oligomers are now widely recognized as key pathogenic structures in Alzheimer's disease. They inhibit synaptic function, leading to early memory deficits and synaptic degeneration, and they trigger the downstream neuronal signaling respon
Publikováno v:
Alzheimer's Research & Therapy
Levels of amyloid-beta monomer and deposited amyloid-beta in the Alzheimer’s disease brain are orders of magnitude greater than soluble amyloid-beta oligomer levels. Monomeric amyloid-beta has no known direct toxicity. Insoluble fibrillar amyloid-b