Výsledky vyhledávání - "Jasmine V. Abella"

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

Autor: Christophe Guérin, Pavithra Singaravelu, Laurent Blanchoin, Naoko Kogata, Svend Kjaer, Davide Carra, Michael Way, Chiara Galloni, Jasmine V. Abella, David J. Barry

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, 2021, 220 (8), pp.e202102043. ⟨10.1083/jcb.202102043⟩
Journal of Cell Biology, Rockefeller University Press, 2021, 220 (8), pp.e202102043. ⟨10.1083/jcb.202102043⟩

Galloni, Carra, et al. demonstrate that Arp3B isoform–specific Arp2/3 complexes generate branched actin networks with faster disassembly kinetics. This increased turnover is due to oxidation of Met293 of Arp3B by the methionine monooxygenase MICAL2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d9076f307f4a81eb04977bef68a426
http://europepmc.org/articles/PMC8193582

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MICAL2 acts through Arp3B isoform-specific Arp2/3 complexes to destabilize branched actin networks

Autor: Svend Kjaer, Laurent Blanchoin, Davide Carra, Michael Way, David J. Barry, Jasmine V. Abella, Pavithra Singaravelu, Chiara Galloni, Naoko Kogata, Christophe Guérin

The Arp2/3 complex (Arp2, Arp3 and ARPC1-5) is essential to generate branched actin filament networks for many cellular processes. Human Arp3, ARPC1 and ARPC5 exist as two isoforms but the functional properties of Arp2/3 iso-complexes is largely unex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a77a1713d8760418fd1c0cef81af3bc
https://doi.org/10.1101/2020.09.21.306522

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Open source software for quantification of cell migration, protrusions, and fluorescence intensities

Autor: Jasmine V. Abella, David J. Barry, Michael Way, Charlotte H. Durkin

Publikováno v: The Journal of Cell Biology

ADAPT is an ImageJ plug-in that can be used for rapid whole-cell analysis of time-lapse videos, thereby providing data on cell morphology, membrane velocity, and temporal changes in any fluorescent protein of interest at the cell periphery, as exempl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ba3d102e9c36eb541ba7d23bd5ae44
https://doi.org/10.1083/jcb.201501081

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Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle

Autor: Raphaël Voituriez, Filomena A. Carvalho, Nuno C. Santos, João P. Martins, Michael Way, Bruno Cadot, Jasmine V. Abella, William Roman, Edgar R. Gomes

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Cell Biology
Nature Cell Biology, 2017, 19 (10), pp.1189-1201. ⟨10.1038/ncb3605⟩
Nature cell biology

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Nuclear movements are important for multiple cellular functions, and are driven by polarized forces generated by motor proteins and the cytoskeleton. During skel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba7492a3da58168ba9231a307d346ba

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Actin'g against the Ball and Chain

Autor: Jasmine V. Abella, Michael Way

Publikováno v: Developmental cell. 37(1)

Mutations in the Kv3.3 potassium channel (KCNC3) cause cerebellar neurodegeneration and impair auditory processing. The cytoplasmic C-terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate actin nucleation through Arp2/3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55da6b0021dd6bc3cc675261dc6ed7aa
https://pubmed.ncbi.nlm.nih.gov/26997484

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GGA3 Functions as a Switch to Promote Met Receptor Recycling, Essential for Sustained ERK and Cell Migration

Autor: James H. Keen, Yi Luo, Morag Park, Jasmine V. Abella, Christine A. Parachoniak

Publikováno v: Developmental Cell. 20:751-763

SummaryCells are dependent on correct sorting of activated receptor tyrosine kinases (RTKs) for the outcome of growth factor signaling. Upon activation, RTKs are coupled through the endocytic machinery for degradation or recycled to the cell surface.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ec9bd5644eaaa89a1977d9819041c8
https://doi.org/10.1016/j.devcel.2011.05.007

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Dorsal Ruffle Microdomains Potentiate Met Receptor Tyrosine Kinase Signaling and Down-regulation

Autor: Morag Park, Christine A. Parachoniak, Veena Sangwan, Jasmine V. Abella

Publikováno v: Journal of Biological Chemistry. 285:24956-24967

Dorsal ruffles are apical protrusions induced in response to many growth factors, yet their function is poorly understood. Here we report that downstream from the hepatocyte growth factor (HGF) receptor tyrosine kinase (RTK), Met, dorsal ruffles func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b050bc328a3af08062f78d87ee24f356
https://doi.org/10.1074/jbc.m110.127985

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PTP1B Targets the Endosomal Sorting Machinery

Autor: Jasmine V. Abella, Blagoy Blagoev, Morag Park, Michel L. Tremblay, Misha Nossov, Veena Sangwan, Matthew Feldhammer, Matthew Stuible

Publikováno v: Journal of Biological Chemistry. 285:23899-23907

Dephosphorylation and endocytic down-regulation are distinct processes that together control the signaling output of a variety of receptor tyrosine kinases (RTKs). PTP1B can directly dephosphorylate several RTKs, but it can also promote activation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a323fc8dfc6c93e4c55c2bfda60e003
https://doi.org/10.1074/jbc.m110.115295

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Crosstalk in Met receptor oncogenesis

Autor: Morag Park, Jasmine V. Abella, Andrea Z. Lai

Publikováno v: Trends in Cell Biology. 19:542-551

The Met receptor tyrosine kinase (RTK) regulates several distinct biological processes, including cell scatter, cell invasion, cell survival and epithelial remodeling. MET is genetically altered through several mechanisms in multiple human cancers; t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f866d162ecdfeb6a34896050b9656f3
https://doi.org/10.1016/j.tcb.2009.07.002

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Regulation of the Met Receptor-tyrosine Kinase by the Protein-tyrosine Phosphatase 1B and T-cell Phosphatase

Autor: Veena Sangwan, Michel L. Tremblay, Anie Monast, Morag Park, Nadia Dubé, Grigorios N. Paliouras, Jasmine V. Abella

Publikováno v: Journal of Biological Chemistry. 283:34374-34383

The non-receptor protein-tyrosine phosphatases (PTPs) 1B and T-cell phosphatase (TCPTP) have been implicated as negative regulators of multiple signaling pathways including receptor-tyrosine kinases. We have identified PTP1B and TCPTP as negative reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c76aae9f1d0e7483e68d0402466e85
https://doi.org/10.1074/jbc.m805916200

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