Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jasmine C. Wong"'
Autor:
Jasmine C. Wong, Pedro A. Perez-Mancera, Tannie Q. Huang, Jangkyung Kim, Joaquim Grego-Bessa, Maria del pilar Alzamora, Scott C. Kogan, Amnon Sharir, Susan H. Keefe, Carolina E. Morales, Denny Schanze, Pau Castel, Kentaro Hirose, Guo N. Huang, Martin Zenker, Dean Sheppard, Ophir D. Klein, David A. Tuveson, Benjamin S. Braun, Kevin Shannon
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of germline KRAS mutations causes developmental disorders called RASopathies. The mutant proteins encoded by these germline KRAS mutations are less biochemi
Externí odkaz:
https://doaj.org/article/3d9175f56bd4469b9994c659c5e9bbbc
Autor:
Tamara Westover, Sherif Abdelhamed, Emily Xiong, Michael P Walsh, Jing Ma, Jasmine C. Wong, Astrid Behnert, Mignon L. Loh, Kevin M. Shannon, Jeffery M. Klco
Publikováno v:
Blood. 140:5837-5838
Autor:
Jasmine C Wong, Kelley M Weinfurtner, Maria del pilar Alzamora, Scott C Kogan, Michael R Burgess, Yan Zhang, Joy Nakitandwe, Jing Ma, Jinjun Cheng, Shann-Ching Chen, Theodore T Ho, Johanna Flach, Damien Reynaud, Emmanuelle Passegué, James R Downing, Kevin Shannon
Publikováno v:
eLife, Vol 4 (2015)
Chromosome 7 deletions are highly prevalent in myelodysplastic syndrome (MDS) and likely contribute to aberrant growth through haploinsufficiency. We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 synt
Externí odkaz:
https://doaj.org/article/22ff762d87894c87b32f30861437c04b
Autor:
Qing Li, Jon C. Aster, Hannah Yan, Joy Nakitandwe, Kevin Shannon, Robert P. Hasserjian, Alessandro Scacchetti, Jasmine C. Wong, Olga K. Weinberg, James R. Downing, Monique Dail, Anica M. Wandler, Jeffrey W. Craig, Jinghui Zhang, Lauren K. Meyer, Benjamin J. Huang, Philip Jonsson, Kathryn Hayes, Deepak Sampath, Gabriela C. Monsalve, Keith R. Yamamoto, Scott C. Kogan, Barry S. Taylor
Publikováno v:
Leukemia, vol 34, iss 8
Leukemia
Leukemia
Despite decades of clinical use, mechanisms of glucocorticoid resistance are poorly understood. We treated primary murine T lineage acute lymphoblastic leukemias (T-ALLs) with the glucocorticoid dexamethasone (DEX) alone and in combination with the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeabda681f2400375386b07498df6cf
https://escholarship.org/uc/item/7gx9m1r6
https://escholarship.org/uc/item/7gx9m1r6
Autor:
Benjamin F. Cravatt, Noemi A. Zambetti, Anagha Inguva, Benjamin J. Huang, Jarrett R. Remsberg, Ari J. Firestone, Kevin Shannon, Jasmine C. Wong, Scott C. Kogan, Amanda M. Long, Kevin M. Haigis, Radu M. Suciu, Marina Predovic
Publikováno v:
Blood, vol 135, iss 20
Oncogenic RAS mutations pose substantial challenges for rational drug discovery. Sequence variations within the hypervariable region of Ras isoforms underlie differential posttranslational modification and subcellular trafficking, potentially resulti
Autor:
Anneleen Daemen, Jasmine C. Wong, Xinyue Wang, Joy Nakitandwe, Anica M. Wandler, Kevin Shannon, Monique Dail, Jinghui Zhang, Lauren K. Meyer, Benjamin J. Huang, Qing Li, Deepak Sampath, Barry S. Taylor, James R. Downing
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008168 (2019)
PLoS Genetics
PLoS genetics, vol 15, iss 6
PLoS Genetics
PLoS genetics, vol 15, iss 6
The lack of predictive preclinical models is a fundamental barrier to translating knowledge about the molecular pathogenesis of cancer into improved therapies. Insertional mutagenesis (IM) in mice is a robust strategy for generating malignancies that
Autor:
Jasmine C. Wong, Jarrett R. Remsberg, Ari J. Firestone, Amanda M. Long, Kevin M. Haigis, Benjamin F. Cravatt, Noemi A. Zambetti, Kevin Shannon, Anagha Inguva, Radu M. Suciu
Publikováno v:
Molecular Cancer Research. 18:A25-A25
A dynamic cycle of palmitoylation and depalmitoylation stably localizes N-Ras, but not K-Ras-4b, at the plasma membrane. This selective dependency suggests that targeting palmitoylation could inhibit the growth of NRAS-mutant cancers while leaving no
Autor:
Kuang-Yu Jen, Kevin Shannon, Eric A. Collisson, Pedro A. Perez-Mancera, Ari J. Firestone, Jasmine C. Wong, Jangkyung Kim, Scott C. Kogan, David A. Tuveson
Publikováno v:
Molecular Cancer Research. 18:A23-A23
Phosphatidylinositol 3-kinase (PI3K) signaling is essential for RAS-driven transformation. To directly investigate the role of oncogenic K-Ras binding to PI3K in development and tumorigenesis, we generated KrasG12D/+,Y64G/+ mice that express, from th
Autor:
Mignon L. Loh, Jeffrey H. Davis, Rochelle Yanofsky, Tamara Lamprecht, Paul Rogers, James R. Downing, Sara J. Israels, Jason R. Schwartz, Victoria Bryant, Jeffery M. Klco, Maria del pilar Alzamora, Michael Walsh, Raul C. Ribeiro, Kevin Shannon, Stuart H. Gold, Jing Ma, Jasmine C. Wong, Charles G. Mullighan, William L. Carroll
Publikováno v:
JCI insight. 3(14)
Germline SAMD9 and SAMD9L mutations cause a spectrum of multisystem disorders that carry a markedly increased risk of developing myeloid malignancies with somatic monosomy 7. Here, we describe 16 siblings, the majority of which were phenotypically no
Autor:
Andrew S. McDaniel, Tyler Jacks, Linda Wolff, Emily Harding-Theobald, Jasmine C. Wong, Qing Li, Keiko Akagi, Kevin M. Haigis, Benjamin S. Braun, Kevin Shannon, Scott C. Kogan
Publikováno v:
Blood. 117:2022-2032
NRAS is frequently mutated in hematologic malignancies. We generated Mx1-Cre, Lox-STOP-Lox (LSL)-NrasG12D mice to comprehensively analyze the phenotypic, cellular, and biochemical consequences of endogenous oncogenic Nras expression in hematopoietic