Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus

Autor: Jasmine Rowell, Ching-In Lau, Susan Ross, Diana C Yanez, Oscar A Peña, Benny Chain, Tessa Crompton

Publikováno v: eLife, Vol 13 (2024)

Here, we sequenced rearranged TCRβ and TCRα chain sequences in CD4+CD8+ double positive (DP), CD4+CD8- single positive (SP4) and CD4-CD8+ (SP8) thymocyte populations from the foetus and young adult mouse. We found that life-stage had a greater impa

Externí odkaz: https://doaj.org/article/cad8f80190414a5682a9e4cb024960d6

Systemic Pharmacological Smoothened Inhibition Reduces Lung T-Cell Infiltration and Ameliorates Th2 Inflammation in a Mouse Model of Allergic Airway Disease

Autor: Diana C. Yánez, Eleftheria Papaioannou, Mira M. Chawda, Jasmine Rowell, Susan Ross, Ching-In Lau, Tessa Crompton

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association

Externí odkaz: https://doaj.org/article/52cdf4f55f4a447bb6f4d6b8242eaacb

Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus

Autor: Konstantinos Mengrelis, Ching-In Lau, Jasmine Rowell, Anisha Solanki, Sonia Norris, Susan Ross, Masahiro Ono, Susan Outram, Tessa Crompton

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effecto

Externí odkaz: https://doaj.org/article/4328ac17533e4de091c065c06209e14a

Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish

Autor: Jasmine Rowell, Chianna Umamahesan, Oscar A Peña, Phoebe Dace, Hanna Lemmik, Yvette Hoade, Alexandra Lubin, Christopher B. Mahony, Elspeth Payne, Noreen Khokhar

Publikováno v: Peña, O A, Lubin, A, Rowell, J, Hoade, Y, Khokhar, N, Lemmik, H, Mahony, C, Dace, P, Umamahesan, C & Payne, E M 2021, ' Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish ', Frontiers in Cell and Developmental Biology, vol. 9, 708113 . https://doi.org/10.3389/fcell.2021.708113
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Germline loss or mutation of one copy of the transcription factor GATA2 in humans leads to a range of clinical phenotypes affecting hematopoietic, lymphatic and vascular systems. GATA2 heterozygous mice show only a limited repertoire of the features

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de74ce600599b2703d09134c1bc007c
https://hdl.handle.net/1983/ba9a5231-fe2f-46e5-9819-5c45098d1762

The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selection

Autor: Ching-In Lau, Susan Ross, Anisha Solanki, Jasmine Rowell, Masahiro Ono, Diana C. Yánez, Tessa Crompton

Publikováno v: Development (Cambridge, England)
article-version (VoR) Version of Record

During positive selection at the transition from CD4+CD8+ double-positive (DP) to single-positive (SP) thymocyte, TCR signalling results in appropriate MHC restriction and signals for survival and progression. We show that the pioneer transcription f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d597dc219169cc3174e78feeceb0ef
https://pubmed.ncbi.nlm.nih.gov/34323272