Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jasmina Kravic"'
Autor:
Clement Ma, Liisa Hakaste, Claes Ladenvall, Massimo Mangino, Lars Lind, Aaron G. Day-Williams, Ryan Poplin, Thomas Schwarzmayr, Annette Peters, Thomas Meitinger, Satish Kumar, Kyong Soo Park, Ching-Yu Cheng, Farook Thameem, Kyle J. Gaulton, Olov Rolandsson, Yossi Farjoun, Neil Robertson, Mauricio O. Carneiro, Mark A. DePristo, Pierre Fontanillas, Ruth J. F. Loos, Heather M. Highland, Vilmantas Giedraitis, Gemma Buck, Fredrik Karpe, Mohammad Kamran Ikram, Alex S. F. Doney, Hae Kyung Im, Eric S. Lander, Johanna Kuusisto, Dorothée Thuillier, Denis Rybin, Jacquelyn Murphy, Benjamin M. Neale, Martina Müller-Nurasyid, Eric R. Gamazon, Johanne Marie Justesen, Tin Aung, Vincent K. L. Lam, John Danesh, Donna M. Lehman, Goo Jun, Marit E. Jørgensen, Christian Herder, Edmund Chan, Pamela J. Hicks, Todd Green, Claudia Langenberg, Yoon Shin Cho, James G. Wilson, Daniel E. Hale, Rector Arya, Giriraj R. Chandak, Juan Fernandez Tajes, Jaakko Tuomilehto, Christopher P. Jenkinson, Anders Rosengren, Torsten Lauritzen, Michael Griswold, Karen L. Mohlke, Amy J. Swift, Alena Stančáková, Christian Fuchsberger, Iksoo Huh, Nikhil Tandon, João Fadista, Christa Meisinger, Gonçalo R. Abecasis, Pål R. Njølstad, Dwaipayan Bharadwaj, Richard M. Watanabe, Shaun Purcell, Veikko Salomaa, Tim D. Spector, Paul W. Franks, Adam E. Locke, Sharon P. Fowler, Panos Deloukas, Reedik Mägi, Solomon K. Musani, Kee Seng Chia, Barbara Thorand, Soo Heon Kwak, Annemari Käräjämäki, Evelin Mihailov, John Blangero, Thomas Wieland, Christian Gieger, E. Shyong Tai, Jianjun Liu, James B. Meigs, Teemu Kuulasmaa, Martin Hrabé de Angelis, Francis S. Collins, Tim M. Strom, Tibor V. Varga, Juyoung Lee, Mark I. McCarthy, Domenico Palli, Jong-Young Lee, Benjamin Glaser, Tasha E. Fingerlin, Stephen O'Rahilly, Andrew T. Hattersley, Gil Atzmon, Manuel A. Rivas, Noël P. Burtt, Ivan Brandslund, Young-Jin Kim, Dorairaj Prabhakaran, Xu Wang, Taylor J. Maxwell, Valeriya Lyssenko, Frank B. Hu, Adolfo Correa, Khalid Shakir, Kathleen A. Jablonski, Yingchang Lu, Wei-Yen Lim, Min Jin Go, William R. Scott, Hanna E. Abboud, Leena Kinnunen, Inês Barroso, Gabriela L. Surdulescu, Peng Chen, Robert Sladek, Marju Orho-Melander, Xueling Sim, Robert A. Scott, Joanna M. M. Howson, Markku Laakso, David Altshuler, Vidya S. Farook, Harald Grallert, Janina S. Ried, Vineeta Agarwala, Philippe Froguel, Nicholas J. Wareham, Tiinamaija Tuomi, Joon Yoon, Heikki A. Koistinen, Toni I. Pollin, Heiner Boeing, Marie Loh, Nicola L. Beer, Joanne E. Curran, Lars Lannfelt, Dorota Pasko, Taesung Park, David Buck, Nir Barzilai, Stephen C. J. Parker, Michael Roden, Bok-Ghee Han, David Aguilar, Timothy Fennell, Sian-Tsung Tan, Gregory P. Wilson, Momoko Horikoshi, Cramer Christensen, Craig L. Hanis, Gilean McVean, Benjamin F. Voight, Wolfgang Rathmann, Jared Maguire, Ashok Kumar, Donald W. Bowden, Michael L. Stitzel, Yongkang Kim, Christine Blancher, Jason Carey, Min-Seok Kwon, Nicholette D. Palmer, Oluf Pedersen, Niels Grarup, Peter S. Chines, Cornelia Huth, James Scott, Torben Hansen, Konstantin Strauch, Erwin P. Bottinger, Andrew D. Morris, Anette P. Gjesing, Erik Ingelsson, Colin N. A. Palmer, Claudia H. T. Tam, Stacey Gabriel, Pablo Cingolani, Beverley Balkau, Michael Boehnke, Peter M. Nilsson, Wing-Yee So, Andrew R. Wood, Lili Milani, Ravindranath Duggirala, Qibin Qi, Mark Walker, Weiping Jia, Mark Seielstad, Narisu Narisu, Tien Yin Wong, Martijn van de Bunt, Anubha Mahajan, Davis J. McCarthy, Ann-Christine Syvänen, Jennifer Kriebel, N. William Rayner, Han Chen, Jinyan Huang, Chiea Chuen Khor, Richard N. Bergman, Shah Ebrahim, Dylan Hodgkiss, Weihua Zhang, Manjinder S. Sandhu, Richard D. Pearson, Juliana C.N. Chan, Rainer Rauramaa, Ralph A. DeFronzo, Andrew Farmer, Yoshihiko Nagai, Allan Linneberg, Herman A. Taylor, Jose C. Florez, Jaspal S. Kooner, Lori L. Bonnycastle, Jeroen R. Huyghe, Leif Groop, Joseph Trakalo, Sobha Puppala, Bong-Jo Kim, Kathleen Stirrups, Kerrin S. Small, Cecilia M. Lindgren, Jennifer E. Below, Heung Man Lee, Inga Prokopenko, Liming Liang, Timothy M. Frayling, Uzma Afzal, Mark J. Daly, Yik Ying Teo, Andrew P. Morris, Phoenix Kwan, Yvonne T. van der Schouw, Cheng Hu, Katharine R. Owen, Alisa K. Manning, Christopher J. Groves, Josée Dupuis, Ryan P. Welch, Loukas Moutsianas, Joshua D. Smith, Tanya M. Teslovich, Robert C. Onofrio, Maggie C.Y. Ng, Peter Donnelly, Tõnu Esko, Matt Neville, Bo Isomaa, Anne U. Jackson, Jette Bork-Jensen, Barry I. Freedman, Yi Chen, Danish Saleheen, Lu Qi, Laura J. Scott, Jasmina Kravic, Paul Elliott, Mette Hollensted, Carmen Navarro, Selyeong Lee, Benjamin Lehne, Thomas Illig, Nancy J. Cox, Jonathan C. Levy, George B. Grant, John C. Chambers, Adam S. Butterworth, Ronald C.W. Ma, Teresa Ferreira, John R. B. Perry, Eleftheria Zeggini, Hyun Min Kang, Loic Yengo, Eric Banks, Jae-Hoon Lee, Anna L. Gloyn, Christopher Hartl, Wei Zhao, Andres Metspalu, Keng-Han Lin, Graeme I. Bell, Jason Flannick, Torben Jørgensen, Thomas W. Blackwell, Heather M. Stringham, Olle Melander, Omri Gottesman
Publikováno v:
Nature, 536(7614), 41-+. Nature Publishing Group
Fuchsberger, C, Flannick, J, Teslovich, T M, Mahajan, A, Agarwala, V, Gaulton, K J, Ma, C, Fontanillas, P, Moutsianas, L, McCarthy, D J, Rivas, M A, Perry, J R B, Sim, X, Blackwell, T W, Robertson, N R, Rayner, N W, Cingolani, P, Locke, A E, Tajes, J F, Highland, H M, Dupuis, J, Chines, P S, Lindgren, C M, Hartl, C, Jackson, A U, Chen, H, Huyghe, J R, van de Bunt, M, Pearson, R D, Kumar, A, Müller-Nurasyid, M, Grarup, N, Stringham, H M, Gamazon, E R, Lee, J, Chen, Y, Scott, R A, Below, J E, Chen, P, Huang, J, Go, M J, Stitzel, M L, Pasko, D, Parker, S C J, Varga, T V, Green, T, Beer, N L, Day-Williams, A G, Ferreira, T, Fingerlin, T, Horikoshi, M, Hu, C, Huh, I, Ikram, M K, Kim, B-J, Kim, Y, Kim, Y J, Kwon, M-S, Lee, J, Lee, S, Lin, K-H, Maxwell, T J, Nagai, Y, Wang, X, Welch, R P, Yoon, J, Zhang, W, Barzilai, N, Voight, B F, Han, B-G, Jenkinson, C P, Kuulasmaa, T, Kuusisto, J, Manning, A, Ng, M C Y, Palmer, N D, Balkau, B, Stančáková, A, Abboud, H E, Boeing, H, Giedraitis, V, Prabhakaran, D, Gottesman, O, Scott, J, Carey, J, Kwan, P, Grant, G, Smith, J D, Neale, B M, Purcell, S, Butterworth, A S, Howson, J M M, Lee, H M, Lu, Y, Kwak, S-H, Zhao, W, Danesh, J, Lam, V K L, Park, K S, Saleheen, D, So, W Y, Tam, C H T, Afzal, U, Aguilar, D, Arya, R, Aung, T, Chan, E, Navarro, C, Cheng, C-Y, Palli, D, Correa, A, Curran, J E, Rybin, D, Farook, V S, Fowler, S P, Freedman, B I, Griswold, M, Hale, D E, Hicks, P J, Khor, C-C, Kumar, S, Lehne, B, Thuillier, D, Lim, W Y, Liu, J, van der Schouw, Y T, Loh, M, Musani, S K, Puppala, S, Scott, W R, Yengo, L, Tan, S-T, Taylor, H A, Thameem, F, Wilson, G, Wong, T Y, Njølstad, P R, Levy, J C, Mangino, M, Bonnycastle, L L, Schwarzmayr, T, Fadista, J, Surdulescu, G L, Herder, C, Groves, C J, Wieland, T, Bork-Jensen, J, Brandslund, I, Christensen, C, Koistinen, H A, Doney, A S F, Kinnunen, L, Esko, T, Farmer, A J, Hakaste, L, Hodgkiss, D, Kravic, J, Lyssenko, V, Hollensted, M, Jørgensen, M E, Jørgensen, T, Ladenvall, C, Justesen, J M, Käräjämäki, A, Kriebel, J, Rathmann, W, Lannfelt, L, Lauritzen, T, Narisu, N, Linneberg, A, Melander, O, Milani, L, Neville, M, Orho-Melander, M, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Swift, A, Rosengren, A H, Stirrups, K, Wood, A R, Mihailov, E, Blancher, C, Carneiro, M O, Maguire, J, Poplin, R, Shakir, K, Fennell, T, DePristo, M, Hrabé de Angelis, M, Deloukas, P, Gjesing, A P, Jun, G, Nilsson, P, Murphy, J, Onofrio, R, Thorand, B, Hansen, T, Meisinger, C, Hu, F B, Isomaa, B, Karpe, F, Liang, L, Peters, A, Huth, C, O'Rahilly, S P, Palmer, C N A, Pedersen, O, Rauramaa, R, Tuomilehto, J, Salomaa, V, Watanabe, R M, Syvänen, A-C, Bergman, R N, Bharadwaj, D, Bottinger, E P, Cho, Y S, Chandak, G R, Chan, J C N, Chia, K S, Daly, M J, Ebrahim, S B, Langenberg, C, Elliott, P, Jablonski, K A, Lehman, D M, Jia, W, Ma, R C W, Pollin, T I, Sandhu, M, Tandon, N, Froguel, P, Barroso, I, Teo, Y Y, Zeggini, E, Loos, R J F, Small, K S, Ried, J S, DeFronzo, R A, Grallert, H, Glaser, B, Metspalu, A, Wareham, N J, Walker, M, Banks, E, Gieger, C, Ingelsson, E, Im, H K, Illig, T, Franks, P W, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Mägi, R, Lind, L, Farjoun, Y, Owen, K R, Gloyn, A L, Strauch, K, Tuomi, T, Kooner, J S, Lee, J-Y, Park, T, Donnelly, P, Morris, A D, Hattersley, A T, Bowden, D W, Collins, F S, Atzmon, G, Chambers, J C, Spector, T D, Laakso, M, Strom, T M, Bell, G I, Blangero, J, Duggirala, R, Tai, E S, McVean, G, Hanis, C L, Wilson, J G, Seielstad, M, Frayling, T M, Meigs, J B, Cox, N J, Sladek, R, Lander, E S, Gabriel, S, Burtt, N P, Mohlke, K L, Meitinger, T, Groop, L, Abecasis, G, Florez, J C, Scott, L J, Morris, A P, Kang, H M, Boehnke, M, Altshuler, D & McCarthy, M I 2016, ' The genetic architecture of type 2 diabetes ', Nature, vol. 536, no. 7614, pp. 41-47 . https://doi.org/10.1038/nature18642
NATURE
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Fuchsberger, C, Flannick, J, Teslovich, T M, Mahajan, A, Agarwala, V, Gaulton, K J, Ma, C, Fontanillas, P, Moutsianas, L, McCarthy, D J, Rivas, M A, Perry, J R B, Sim, X, Blackwell, T W, Robertson, N R, Rayner, N W, Cingolani, P, Locke, A E, Tajes, J F, Highland, H M, Dupuis, J, Chines, P S, Lindgren, C M, Hartl, C, Jackson, A U, Chen, H, Huyghe, J R, van de Bunt, M, Pearson, R D, Kumar, A, Mueller-Nurasyid, M, Grarup, N, Stringham, H M, Gamazon, E R, Lee, J, Chen, Y, Scott, R A, Below, J E, Chen, P-M, Huang, J, Go, M J, Stitzel, M L, Pasko, D, Parker, S C J, Varga, T V, Green, T, Beer, N L, Day-Williams, A G, Ferreira, T, Fingerlin, T, Horikoshi, M, Hu, C, Huh, I, Ikram, M K, Kim, B-J, Kim, Y, Kim, Y J, Kwon, M-S, Lee, J, Lee, S, Lin, K-H, Maxwell, T J, Nagai, Y, Wang, X-G, Welch, R P, Yoon, J, Zhang, W, Barzilai, N, Voight, B F, Han, B-G, Jenkinson, C P, Kuulasmaa, T, Kuusisto, J, Manning, A K, Ng, M C Y, Palmer, N D, Balkau, B, Stancáková, A, Abboud, H E, Boeing, H, Giedraitis, V, Prabhakaran, D, Gottesman, O, Scott, J, Carey, J, Kwan, P, Grant, G, Smith, J D, Neale, B M, Purcell, S, Butterworth, A S, Howson, J M M, Lee, H M, Lu, Y, Kwak, S-H, Zhao, W, Danesh, J, Lam, V K L, Park, K S, Saleheen, D, So, W-Y, Tam, C H T, Afzal, U, Aguilar, D, Arya, R, Aung, T, Chan, E, Navarro, C, Cheng, C-Y, Palli, D, Correa, A, Curran, J E, Rybin, D, Farook, V S, Fowler, S P, Freedman, B I, Griswold, M E, Hale, D E, Hicks, P J, Khor, C-C, Kumar, S, Lehne, B, Thuillier, D, Lim, W Y, Liu, J, van der Schouw, Y T, Loh, M, Musani, S K, Puppala, S, Scott, W R, Yengo, L, Tan, S-T, Taylor, H A, Thameem, F, Wilson, G A, Wong, T Y, Njolstad, P R, Levy, J C, Mangino, M, Bonnycastle, L L, Schwarzmayr, T, Fadista, J, Surdulescu, G L, Herder, C, Groves, C J, Wieland, T, Bork-Jensen, J, Brandslund, I, Christensen, C, Koistinen, H A, Doney, A S F, Kinnunen, L, Esko, T, Farmer, A J, Hakaste, L, Hodgkiss, D, Kravic, J, Lyssenko, V, Hollensted, M, Jorgensen, M E, Jorgensen, T, Ladenvall, C, Justesen, J M, Karajamaki, A, Kriebel, J, Rathmann, W, Lannfelt, L, Lauritzen, T, Narisu, N, Linneberg, A, Melander, O, Milani, L, Neville, M J, Orho-Melander, M, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Swift, A J, Rosengren, A H, Stirrups, K, Wood, A R, Mihailov, E, Blancher, C, Carneiro, M O, Maguire, J, Poplin, R, Shakir, K, Fennell, T, DePristo, M, de Angelis, M H, Deloukas, P, Gjesing, A P, Jun, G, Nilsson, P, Murphy, J, Onofrio, R, Thorand, B, Hansen, T, Meisinger, C, Hu, F B, Isomaa, B, Karpe, F, Liang, L, Peters, A, Huth, C, O'Rahilly, S P, Palmer, C N A, Pedersen, O, Rauramaa, R, Tuomilehto, J, Salomaa, V, Watanabe, R M, Syvanen, A-C, Bergman, R N, Bharadwaj, D, Bottinger, E P, Cho, Y S, Chandak, G R, Chan, J C N, Chia, K S, Daly, M J, Ebrahim, S B, Langenberg, C, Elliott, P, Jablonski, K A, Lehman, D M, Jia, W, Ma, R C W, Pollin, T I, Sandhu, M S, Tandon, N, Froguel, P, Barroso, I, Teo, Y Y, Zeggini, E, Loos, R J F, Small, K S, Ried, J S, DeFronzo, R A, Grallert, H, Glaser, B, Metspalu, A, Wareham, N J, Walker, M, Banks, E, Gieger, C, Ingelsson, E, Im, H K, Illig, T, Franks, P W, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Magi, R, Lind, L, Farjoun, Y, Owen, K R, Gloyn, A L, Strauch, K, Tuomi, T, Kooner, J S, Lee, J-Y, Park, T, Donnelly, P, Morris, A D, Hattersley, A T, Bowden, D W, Collins, F S, Atzmon, G, Chambers, J C, Spector, T D, Laakso, M, Strom, T M, Bell, G I, Blangero, J, Duggirala, R, Tai, E S, McVean, G, Hanis, C L, Wilson, J G, Seielstad, M, Frayling, T M, Meigs, J B, Cox, N J, Sladek, R, Lander, E S, Gabriel, S, Burtt, N P, Mohlke, K L, Meitinger, T, Groop, L, Abecasis, G R, Florez, J C, Scott, L J, Morris, A P, Kang, H M, Boehnke, M, Altshuler, D & McCarthy, M I 2016, ' The genetic architecture of type 2 diabetes ', Nature Genetics, vol. 536, no. 7614, pp. 41-+ . https://doi.org/10.1038/nature18642
Fuchsberger, C, Flannick, J, Teslovich, T M, Mahajan, A, Agarwala, V, Gaulton, K J, Ma, C, Fontanillas, P, Moutsianas, L, McCarthy, D J, Rivas, M A, Perry, J R B, Sim, X, Blackwell, T W, Robertson, N R, Rayner, N W, Cingolani, P, Locke, A E, Fernandez Tajes, J, Highland, H M, Dupuis, J, Chines, P S, Lindgren, C M, Hartl, C, Jackson, A U, Chen, H, Huyghe, J R, van de Bunt, M, Pearson, R D, Kumar, A, Müller-Nurasyid, M, Grarup, N, Stringham, H M, Gamazon, E R, Lee, J, Chen, Y, Scott, R A, Below, J E, Chen, P, Huang, J, Go, M J, Stitzel, M L, Pasko, D, Parker, S C J, Varga, T V, Green, T, Beer, N L, Day-Williams, A G, Ferreira, T, Fingerlin, T, Horikoshi, M, Hu, C, Huh, I, Ikram, M K, Kim, B-J, Kim, Y, Kim, Y J, Kwon, M-S, Lee, J, Lee, S, Lin, K-H, Maxwell, T J, Nagai, Y, Wang, X, Welch, R P, Yoon, J, Zhang, W, Barzilai, N, Voight, B F, Han, B-G, Jenkinson, C P, Kuulasmaa, T, Kuusisto, J, Manning, A, Ng, M C Y, Palmer, N D, Balkau, B, Stancáková, A, Abboud, H E, Boeing, H, Giedraitis, V, Prabhakaran, D, Gottesman, O, Scott, J, Carey, J, Kwan, P, Grant, G, Smith, J D, Neale, B M, Purcell, S, Butterworth, A S, Howson, J M M, Lee, H M, Lu, Y, Kwak, S-H, Zhao, W, Danesh, J, Lam, V K L, Park, K S, Saleheen, D, So, W Y, Tam, C H T, Afzal, U, Aguilar, D, Arya, R, Aung, T, Chan, E, Navarro, C, Cheng, C-Y, Palli, D, Correa, A, Curran, J E, Rybin, D, Farook, V S, Fowler, S P, Freedman, B I, Griswold, M, Hale, D E, Hicks, P J, Khor, C-C, Kumar, S, Lehne, B, Thuillier, D, Lim, W Y, Liu, J, van der Schouw, Y T, Loh, M, Musani, S K, Puppala, S, Scott, W R, Yengo, L, Tan, S-T, Taylor, H A, Thameem, F, Wilson, G, Wong, T Y, Njølstad, P R, Levy, J C, Mangino, M, Bonnycastle, L L, Schwarzmayr, T, Fadista, J, Surdulescu, G L, Herder, C, Groves, C J, Wieland, T, Bork-Jensen, J, Brandslund, I, Christensen, C, Koistinen, H A, Doney, A S F, Kinnunen, L, Esko, T, Farmer, A J, Hakaste, L, Hodgkiss, D, Kravic, J, Lyssenko, V, Hollensted, M, Jørgensen, M E, Jørgensen, T, Ladenvall, C, Justesen, J M, Käräjämäki, A, Kriebel, J, Rathmann, W, Lannfelt, L, Lauritzen, T, Narisu, N, Linneberg, A, Melander, O, Milani, L, Neville, M, Orho-Melander, M, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Swift, A, Rosengren, A H, Stirrups, K, Wood, A R, Mihailov, E, Blancher, C, Carneiro, M O, Maguire, J, Poplin, R, Shakir, K, Fennell, T, DePristo, M, Hrabé de Angelis, M, Deloukas, P, Gjesing, A P, Jun, G, Nilsson, P, Murphy, J, Onofrio, R, Thorand, B, Hansen, T, Meisinger, C, Hu, F B, Isomaa, B, Karpe, F, Liang, L, Peters, A, Huth, C, O'Rahilly, S P, Palmer, C N A, Pedersen, O, Rauramaa, R, Tuomilehto, J, Salomaa, V, Watanabe, R M, Syvänen, A-C, Bergman, R N, Bharadwaj, D, Bottinger, E P, Cho, Y S, Chandak, G R, Chan, J C N, Chia, K S, Daly, M J, Ebrahim, S B, Langenberg, C, Elliott, P, Jablonski, K A, Lehman, D M, Jia, W, Ma, R C W, Pollin, T I, Sandhu, M, Tandon, N, Froguel, P, Barroso, I, Teo, Y Y, Zeggini, E, Loos, R J F, Small, K S, Ried, J S, DeFronzo, R A, Grallert, H, Glaser, B, Metspalu, A, Wareham, N J, Walker, M, Banks, E, Gieger, C, Ingelsson, E, Im, H K, Illig, T, Franks, P W, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Mägi, R, Lind, L, Farjoun, Y, Owen, K R, Gloyn, A L, Strauch, K, Tuomi, T, Kooner, J S, Lee, J-Y, Park, T, Donnelly, P, Morris, A D, Hattersley, A T, Bowden, D W, Collins, F S, Atzmon, G, Chambers, J C, Spector, T D, Laakso, M, Strom, T M, Bell, G I, Blangero, J, Duggirala, R, Tai, E S, McVean, G, Hanis, C L, Wilson, J G, Seielstad, M, Frayling, T M, Meigs, J B, Cox, N J, Sladek, R, Lander, E S, Gabriel, S, Burtt, N P, Mohlke, K L, Meitinger, T, Groop, L, Abecasis, G, Florez, J C, Scott, L J, Morris, A P, Kang, H M, Boehnke, M, Altshuler, D & McCarthy, M I 2016, ' The genetic architecture of type 2 diabetes ', Nature, vol. 536, no. 7614, pp. 41-47 . https://doi.org/10.1038/nature18642
PMC
Nature, 536(7614), 41. Nature Publishing Group
Nature
Nature, 536(7614), 41-47. Nature Publishing Group
Fuchsberger, C, Flannick, J, Teslovich, T M, Mahajan, A, Agarwala, V, Gaulton, K J, Ma, C, Fontanillas, P, Moutsianas, L, McCarthy, D J, Rivas, M A, Perry, J R B, Sim, X, Blackwell, T W, Robertson, N R, Rayner, N W, Cingolani, P, Locke, A E, Tajes, J F, Highland, H M, Dupuis, J, Chines, P S, Lindgren, C M, Hartl, C, Jackson, A U, Chen, H, Huyghe, J R, van de Bunt, M, Pearson, R D, Kumar, A, Müller-Nurasyid, M, Grarup, N, Stringham, H M, Gamazon, E R, Lee, J, Chen, Y, Scott, R A, Below, J E, Chen, P, Huang, J, Go, M J, Stitzel, M L, Pasko, D, Parker, S C J, Varga, T V, Green, T, Beer, N L, Day-Williams, A G, Ferreira, T, Fingerlin, T, Horikoshi, M, Hu, C, Huh, I, Ikram, M K, Kim, B-J, Kim, Y, Kim, Y J, Kwon, M-S, Lee, J, Lee, S, Lin, K-H, Maxwell, T J, Nagai, Y, Wang, X, Welch, R P, Yoon, J, Zhang, W, Barzilai, N, Voight, B F, Han, B-G, Jenkinson, C P, Kuulasmaa, T, Kuusisto, J, Manning, A, Ng, M C Y, Palmer, N D, Balkau, B, Stančáková, A, Abboud, H E, Boeing, H, Giedraitis, V, Prabhakaran, D, Gottesman, O, Scott, J, Carey, J, Kwan, P, Grant, G, Smith, J D, Neale, B M, Purcell, S, Butterworth, A S, Howson, J M M, Lee, H M, Lu, Y, Kwak, S-H, Zhao, W, Danesh, J, Lam, V K L, Park, K S, Saleheen, D, So, W Y, Tam, C H T, Afzal, U, Aguilar, D, Arya, R, Aung, T, Chan, E, Navarro, C, Cheng, C-Y, Palli, D, Correa, A, Curran, J E, Rybin, D, Farook, V S, Fowler, S P, Freedman, B I, Griswold, M, Hale, D E, Hicks, P J, Khor, C-C, Kumar, S, Lehne, B, Thuillier, D, Lim, W Y, Liu, J, van der Schouw, Y T, Loh, M, Musani, S K, Puppala, S, Scott, W R, Yengo, L, Tan, S-T, Taylor, H A, Thameem, F, Wilson, G, Wong, T Y, Njølstad, P R, Levy, J C, Mangino, M, Bonnycastle, L L, Schwarzmayr, T, Fadista, J, Surdulescu, G L, Herder, C, Groves, C J, Wieland, T, Bork-Jensen, J, Brandslund, I, Christensen, C, Koistinen, H A, Doney, A S F, Kinnunen, L, Esko, T, Farmer, A J, Hakaste, L, Hodgkiss, D, Kravic, J, Lyssenko, V, Hollensted, M, Jørgensen, M E, Jørgensen, T, Ladenvall, C, Justesen, J M, Käräjämäki, A, Kriebel, J, Rathmann, W, Lannfelt, L, Lauritzen, T, Narisu, N, Linneberg, A, Melander, O, Milani, L, Neville, M, Orho-Melander, M, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Swift, A, Rosengren, A H, Stirrups, K, Wood, A R, Mihailov, E, Blancher, C, Carneiro, M O, Maguire, J, Poplin, R, Shakir, K, Fennell, T, DePristo, M, Hrabé de Angelis, M, Deloukas, P, Gjesing, A P, Jun, G, Nilsson, P, Murphy, J, Onofrio, R, Thorand, B, Hansen, T, Meisinger, C, Hu, F B, Isomaa, B, Karpe, F, Liang, L, Peters, A, Huth, C, O'Rahilly, S P, Palmer, C N A, Pedersen, O, Rauramaa, R, Tuomilehto, J, Salomaa, V, Watanabe, R M, Syvänen, A-C, Bergman, R N, Bharadwaj, D, Bottinger, E P, Cho, Y S, Chandak, G R, Chan, J C N, Chia, K S, Daly, M J, Ebrahim, S B, Langenberg, C, Elliott, P, Jablonski, K A, Lehman, D M, Jia, W, Ma, R C W, Pollin, T I, Sandhu, M, Tandon, N, Froguel, P, Barroso, I, Teo, Y Y, Zeggini, E, Loos, R J F, Small, K S, Ried, J S, DeFronzo, R A, Grallert, H, Glaser, B, Metspalu, A, Wareham, N J, Walker, M, Banks, E, Gieger, C, Ingelsson, E, Im, H K, Illig, T, Franks, P W, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Mägi, R, Lind, L, Farjoun, Y, Owen, K R, Gloyn, A L, Strauch, K, Tuomi, T, Kooner, J S, Lee, J-Y, Park, T, Donnelly, P, Morris, A D, Hattersley, A T, Bowden, D W, Collins, F S, Atzmon, G, Chambers, J C, Spector, T D, Laakso, M, Strom, T M, Bell, G I, Blangero, J, Duggirala, R, Tai, E S, McVean, G, Hanis, C L, Wilson, J G, Seielstad, M, Frayling, T M, Meigs, J B, Cox, N J, Sladek, R, Lander, E S, Gabriel, S, Burtt, N P, Mohlke, K L, Meitinger, T, Groop, L, Abecasis, G, Florez, J C, Scott, L J, Morris, A P, Kang, H M, Boehnke, M, Altshuler, D & McCarthy, M I 2016, ' The genetic architecture of type 2 diabetes ', Nature, vol. 536, no. 7614, pp. 41-47 . https://doi.org/10.1038/nature18642
NATURE
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Fuchsberger, C, Flannick, J, Teslovich, T M, Mahajan, A, Agarwala, V, Gaulton, K J, Ma, C, Fontanillas, P, Moutsianas, L, McCarthy, D J, Rivas, M A, Perry, J R B, Sim, X, Blackwell, T W, Robertson, N R, Rayner, N W, Cingolani, P, Locke, A E, Tajes, J F, Highland, H M, Dupuis, J, Chines, P S, Lindgren, C M, Hartl, C, Jackson, A U, Chen, H, Huyghe, J R, van de Bunt, M, Pearson, R D, Kumar, A, Mueller-Nurasyid, M, Grarup, N, Stringham, H M, Gamazon, E R, Lee, J, Chen, Y, Scott, R A, Below, J E, Chen, P-M, Huang, J, Go, M J, Stitzel, M L, Pasko, D, Parker, S C J, Varga, T V, Green, T, Beer, N L, Day-Williams, A G, Ferreira, T, Fingerlin, T, Horikoshi, M, Hu, C, Huh, I, Ikram, M K, Kim, B-J, Kim, Y, Kim, Y J, Kwon, M-S, Lee, J, Lee, S, Lin, K-H, Maxwell, T J, Nagai, Y, Wang, X-G, Welch, R P, Yoon, J, Zhang, W, Barzilai, N, Voight, B F, Han, B-G, Jenkinson, C P, Kuulasmaa, T, Kuusisto, J, Manning, A K, Ng, M C Y, Palmer, N D, Balkau, B, Stancáková, A, Abboud, H E, Boeing, H, Giedraitis, V, Prabhakaran, D, Gottesman, O, Scott, J, Carey, J, Kwan, P, Grant, G, Smith, J D, Neale, B M, Purcell, S, Butterworth, A S, Howson, J M M, Lee, H M, Lu, Y, Kwak, S-H, Zhao, W, Danesh, J, Lam, V K L, Park, K S, Saleheen, D, So, W-Y, Tam, C H T, Afzal, U, Aguilar, D, Arya, R, Aung, T, Chan, E, Navarro, C, Cheng, C-Y, Palli, D, Correa, A, Curran, J E, Rybin, D, Farook, V S, Fowler, S P, Freedman, B I, Griswold, M E, Hale, D E, Hicks, P J, Khor, C-C, Kumar, S, Lehne, B, Thuillier, D, Lim, W Y, Liu, J, van der Schouw, Y T, Loh, M, Musani, S K, Puppala, S, Scott, W R, Yengo, L, Tan, S-T, Taylor, H A, Thameem, F, Wilson, G A, Wong, T Y, Njolstad, P R, Levy, J C, Mangino, M, Bonnycastle, L L, Schwarzmayr, T, Fadista, J, Surdulescu, G L, Herder, C, Groves, C J, Wieland, T, Bork-Jensen, J, Brandslund, I, Christensen, C, Koistinen, H A, Doney, A S F, Kinnunen, L, Esko, T, Farmer, A J, Hakaste, L, Hodgkiss, D, Kravic, J, Lyssenko, V, Hollensted, M, Jorgensen, M E, Jorgensen, T, Ladenvall, C, Justesen, J M, Karajamaki, A, Kriebel, J, Rathmann, W, Lannfelt, L, Lauritzen, T, Narisu, N, Linneberg, A, Melander, O, Milani, L, Neville, M J, Orho-Melander, M, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Swift, A J, Rosengren, A H, Stirrups, K, Wood, A R, Mihailov, E, Blancher, C, Carneiro, M O, Maguire, J, Poplin, R, Shakir, K, Fennell, T, DePristo, M, de Angelis, M H, Deloukas, P, Gjesing, A P, Jun, G, Nilsson, P, Murphy, J, Onofrio, R, Thorand, B, Hansen, T, Meisinger, C, Hu, F B, Isomaa, B, Karpe, F, Liang, L, Peters, A, Huth, C, O'Rahilly, S P, Palmer, C N A, Pedersen, O, Rauramaa, R, Tuomilehto, J, Salomaa, V, Watanabe, R M, Syvanen, A-C, Bergman, R N, Bharadwaj, D, Bottinger, E P, Cho, Y S, Chandak, G R, Chan, J C N, Chia, K S, Daly, M J, Ebrahim, S B, Langenberg, C, Elliott, P, Jablonski, K A, Lehman, D M, Jia, W, Ma, R C W, Pollin, T I, Sandhu, M S, Tandon, N, Froguel, P, Barroso, I, Teo, Y Y, Zeggini, E, Loos, R J F, Small, K S, Ried, J S, DeFronzo, R A, Grallert, H, Glaser, B, Metspalu, A, Wareham, N J, Walker, M, Banks, E, Gieger, C, Ingelsson, E, Im, H K, Illig, T, Franks, P W, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Magi, R, Lind, L, Farjoun, Y, Owen, K R, Gloyn, A L, Strauch, K, Tuomi, T, Kooner, J S, Lee, J-Y, Park, T, Donnelly, P, Morris, A D, Hattersley, A T, Bowden, D W, Collins, F S, Atzmon, G, Chambers, J C, Spector, T D, Laakso, M, Strom, T M, Bell, G I, Blangero, J, Duggirala, R, Tai, E S, McVean, G, Hanis, C L, Wilson, J G, Seielstad, M, Frayling, T M, Meigs, J B, Cox, N J, Sladek, R, Lander, E S, Gabriel, S, Burtt, N P, Mohlke, K L, Meitinger, T, Groop, L, Abecasis, G R, Florez, J C, Scott, L J, Morris, A P, Kang, H M, Boehnke, M, Altshuler, D & McCarthy, M I 2016, ' The genetic architecture of type 2 diabetes ', Nature Genetics, vol. 536, no. 7614, pp. 41-+ . https://doi.org/10.1038/nature18642
Fuchsberger, C, Flannick, J, Teslovich, T M, Mahajan, A, Agarwala, V, Gaulton, K J, Ma, C, Fontanillas, P, Moutsianas, L, McCarthy, D J, Rivas, M A, Perry, J R B, Sim, X, Blackwell, T W, Robertson, N R, Rayner, N W, Cingolani, P, Locke, A E, Fernandez Tajes, J, Highland, H M, Dupuis, J, Chines, P S, Lindgren, C M, Hartl, C, Jackson, A U, Chen, H, Huyghe, J R, van de Bunt, M, Pearson, R D, Kumar, A, Müller-Nurasyid, M, Grarup, N, Stringham, H M, Gamazon, E R, Lee, J, Chen, Y, Scott, R A, Below, J E, Chen, P, Huang, J, Go, M J, Stitzel, M L, Pasko, D, Parker, S C J, Varga, T V, Green, T, Beer, N L, Day-Williams, A G, Ferreira, T, Fingerlin, T, Horikoshi, M, Hu, C, Huh, I, Ikram, M K, Kim, B-J, Kim, Y, Kim, Y J, Kwon, M-S, Lee, J, Lee, S, Lin, K-H, Maxwell, T J, Nagai, Y, Wang, X, Welch, R P, Yoon, J, Zhang, W, Barzilai, N, Voight, B F, Han, B-G, Jenkinson, C P, Kuulasmaa, T, Kuusisto, J, Manning, A, Ng, M C Y, Palmer, N D, Balkau, B, Stancáková, A, Abboud, H E, Boeing, H, Giedraitis, V, Prabhakaran, D, Gottesman, O, Scott, J, Carey, J, Kwan, P, Grant, G, Smith, J D, Neale, B M, Purcell, S, Butterworth, A S, Howson, J M M, Lee, H M, Lu, Y, Kwak, S-H, Zhao, W, Danesh, J, Lam, V K L, Park, K S, Saleheen, D, So, W Y, Tam, C H T, Afzal, U, Aguilar, D, Arya, R, Aung, T, Chan, E, Navarro, C, Cheng, C-Y, Palli, D, Correa, A, Curran, J E, Rybin, D, Farook, V S, Fowler, S P, Freedman, B I, Griswold, M, Hale, D E, Hicks, P J, Khor, C-C, Kumar, S, Lehne, B, Thuillier, D, Lim, W Y, Liu, J, van der Schouw, Y T, Loh, M, Musani, S K, Puppala, S, Scott, W R, Yengo, L, Tan, S-T, Taylor, H A, Thameem, F, Wilson, G, Wong, T Y, Njølstad, P R, Levy, J C, Mangino, M, Bonnycastle, L L, Schwarzmayr, T, Fadista, J, Surdulescu, G L, Herder, C, Groves, C J, Wieland, T, Bork-Jensen, J, Brandslund, I, Christensen, C, Koistinen, H A, Doney, A S F, Kinnunen, L, Esko, T, Farmer, A J, Hakaste, L, Hodgkiss, D, Kravic, J, Lyssenko, V, Hollensted, M, Jørgensen, M E, Jørgensen, T, Ladenvall, C, Justesen, J M, Käräjämäki, A, Kriebel, J, Rathmann, W, Lannfelt, L, Lauritzen, T, Narisu, N, Linneberg, A, Melander, O, Milani, L, Neville, M, Orho-Melander, M, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Swift, A, Rosengren, A H, Stirrups, K, Wood, A R, Mihailov, E, Blancher, C, Carneiro, M O, Maguire, J, Poplin, R, Shakir, K, Fennell, T, DePristo, M, Hrabé de Angelis, M, Deloukas, P, Gjesing, A P, Jun, G, Nilsson, P, Murphy, J, Onofrio, R, Thorand, B, Hansen, T, Meisinger, C, Hu, F B, Isomaa, B, Karpe, F, Liang, L, Peters, A, Huth, C, O'Rahilly, S P, Palmer, C N A, Pedersen, O, Rauramaa, R, Tuomilehto, J, Salomaa, V, Watanabe, R M, Syvänen, A-C, Bergman, R N, Bharadwaj, D, Bottinger, E P, Cho, Y S, Chandak, G R, Chan, J C N, Chia, K S, Daly, M J, Ebrahim, S B, Langenberg, C, Elliott, P, Jablonski, K A, Lehman, D M, Jia, W, Ma, R C W, Pollin, T I, Sandhu, M, Tandon, N, Froguel, P, Barroso, I, Teo, Y Y, Zeggini, E, Loos, R J F, Small, K S, Ried, J S, DeFronzo, R A, Grallert, H, Glaser, B, Metspalu, A, Wareham, N J, Walker, M, Banks, E, Gieger, C, Ingelsson, E, Im, H K, Illig, T, Franks, P W, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Mägi, R, Lind, L, Farjoun, Y, Owen, K R, Gloyn, A L, Strauch, K, Tuomi, T, Kooner, J S, Lee, J-Y, Park, T, Donnelly, P, Morris, A D, Hattersley, A T, Bowden, D W, Collins, F S, Atzmon, G, Chambers, J C, Spector, T D, Laakso, M, Strom, T M, Bell, G I, Blangero, J, Duggirala, R, Tai, E S, McVean, G, Hanis, C L, Wilson, J G, Seielstad, M, Frayling, T M, Meigs, J B, Cox, N J, Sladek, R, Lander, E S, Gabriel, S, Burtt, N P, Mohlke, K L, Meitinger, T, Groop, L, Abecasis, G, Florez, J C, Scott, L J, Morris, A P, Kang, H M, Boehnke, M, Altshuler, D & McCarthy, M I 2016, ' The genetic architecture of type 2 diabetes ', Nature, vol. 536, no. 7614, pp. 41-47 . https://doi.org/10.1038/nature18642
PMC
Nature, 536(7614), 41. Nature Publishing Group
Nature
Nature, 536(7614), 41-47. Nature Publishing Group
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants as
Autor:
Ching-Ti Liu, Michael Boehnke, George Dedoussis, Sophie V. Eastwood, Ruth J. F. Loos, Keng-Hung Lin, Denis Rybin, Fredrik Karpe, Martina Müller-Nurasyid, Michael A. Province, Alison D. Murray, Bo Isomaa, Eirini Marouli, Konstantin Strauch, Michael Preuss, Paul M. Ridker, Jette Bork-Jensen, Albert V. Smith, Hugoline G. de Haan, Wayne Huey-Herng Sheu, Barbara Thorand, Wolfgang Rathmann, Lawrence F. Bielak, Peter Kovacs, Marit E. Jørgensen, Jennifer Wessel, Danish Saleheen, Jung-Jin Lee, James B. Meigs, Veikko Salomaa, Alena Stančáková, Tibor V. Varga, Hidetoshi Kitajima, Inês Barroso, Kent D. Taylor, Claudia Langenberg, Yoon Shin Cho, Joanna M. M. Howson, Andrew T. Hattersley, Marie-France Hivert, Markku Laakso, Kai-Uwe Eckardt, Bram P. Prins, Matthias B. Schulze, Andrew D. Morris, Susanne Jäger, Francis S. Collins, Kristi Läll, Xu Lin, Anette Varbo, Benjamin Lehne, Girish N. Nadkarni, Jonathan Marchini, Daniel I. Chasman, Michael Stumvoll, Mark O. Goodarzi, Cécile Lecoeur, Philippe M. Frossard, Noël P. Burtt, Frank Kee, Jasmina Kravic, Alain G. Bertoni, Ivan Brandslund, Najaf Amin, Lenore J. Launer, Oluf Pedersen, Johanna Kuusisto, Line Rode, Eleftheria Zeggini, Yingchang Lu, Markus Perola, Helen R. Warren, André G. Uitterlinden, Hanieh Yaghootkar, Torben Hansen, Harald Grallert, Annemari Käräjämäki, Abbas Dehghan, Gina M. Peloso, Yii-Der Ida Chen, Man Li, Shaofeng Huo, Lars Lind, Karen L. Mohlke, Adrienne Tin, Yang Hai, Renée de Mutsert, Gudmar Thorleifsson, Marie Moitry, Sune F. Nielsen, Sara M. Willems, Matthias Wuttke, Weihua Zhang, Young-Jin Kim, Giovanni Malerba, Richard A. Jensen, Loic Yengo, Mickaël Canouil, Kurt Lohman, Robert A. Scott, Tamara B. Harris, Ruifang Li-Gao, Florian Kronenberg, Anke Tönjes, Bok-Ghee Han, Krista Fischer, Thomas Meitinger, James S. Pankow, Jaakko Tuomilehto, Adam S. Butterworth, Jerome I. Rotter, Olov Rolandsson, Xiuqing Guo, Cramer Christensen, Marie Loh, Elizabeth Selvin, Bong-Jo Kim, Audrey Y. Chu, Reedik Mägi, Josée Dupuis, Anna Köttgen, Jean Ferrières, Jin Li, Robert Sladek, Leslie A. Lange, Niels Grarup, Roberta McKean-Cowdin, Cristen J. Willer, Jose C. Florez, Valgerdur Steinthorsdottir, Karina Meidtner, Annette Peters, Børge G. Nordestgaard, Rajiv Chowdhury, Ioanna Ntalla, Emma Ahlqvist, Leif Groop, Nicholas J. Wareham, Kerrin S. Small, Tiinamaija Tuomi, Cecilia M. Lindgren, Katharine R. Owen, Giovanni Gambaro, Cornelia M. van Duijn, Dennis O. Mook-Kanamori, Kenneth Rice, Erik Ingelsson, Colin N. A. Palmer, Sharon L.R. Kardia, Neil R. Robertson, Dajiang J. Liu, Sebastian Schönherr, Daniel Taliun, Sekar Kathiresan, James G. Wilson, Ping An, Patricia A. Peyser, Matthias Blüher, Frits R. Rosendaal, John C. Chambers, Caroline Hayward, Shoaib Afzal, Fernando Rivadineira, Marielisa Graff, Pranav Yajnik, Vasiliki Mamakou, Juan Fernandez Tajes, Stefan Gustafsson, Heather M. Highland, Vilmantas Giedraitis, Andrew R. Wood, Saima Afaq, Jaspal S. Kooner, Megan L. Grove, Jennifer A. Brody, Andrew P. Morris, James P. Cook, Praveen Surendran, Jennifer Kriebel, Heikki A. Koistinen, Kari Stefansson, Anders Rosengren, Rainer Rauramaa, Satu Männistö, Oscar H. Franco, Yongmei Liu, N. William Rayner, Blair H. Smith, Erwin P. Bottinger, Ayse Demirkan, Allan Linneberg, Jonathan Marten, Huaixing Li, Sung Soo Kim, Sophie Hackinger, Cristina Bombieri, Lia B. Bang, Jun Liu, Asif Rasheed, Tim D. Spector, Paul W. Franks, Mark I. McCarthy, Heiner Boeing, Anne E. Justice, Vilmundur Gudnason, Sohee Han, Unnur Thorsteinsdottir, Panos Deloukas, Naveed Sattar, Eric Boerwinkle, Martin Ingelsson, John Danesh, Vassily Trubetskoy, Marco M Ferrario, Marju Orho-Melander, Wei Gan, Philippe Froguel, Symen Ligthart, Susan R. Heckbert, Jie Yao, Anne Tybjærg-Hansen, Robin Young, Daniel R. Witte, Anubha Mahajan, Peter Almgren, Timothy M. Frayling, Tanya M. Teslovich, Matt Neville, Philippe Amouyel, Wei Zhao, Andres Metspalu, Yao Hu, Olle Melander, Kari Kuulasmaa, Jason Flannick, Torben Jørgensen, Stephen S. Rich, Nicole Soranzo, Bruce M. Psaty, Rohit Varma
Publikováno v:
Grarup, N, Jørgensen, M E, Witte, D R, Hansen, T, Pedersen, O, ExomeBP Consortium, MAGIC Consortium & GIANT Consortium 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Mahajan, A, Wessel, J, Willems, S M, Zhao, W, Robertson, N R, Chu, A Y, Gan, W, Kitajima, H, Taliun, D, Rayner, N W, Guo, X, Lu, Y, Li, M, Jensen, R A, Hu, Y, Huo, S, Lohman, K K, Zhang, W, Cook, J P, Prins, B P, Flannick, J, Grarup, N, Trubetskoy, V V, Kravic, J, Kim, Y J, Rybin, D V, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, T V, Marten, J, Li, J, Smith, A V, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, J F, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, L F, Graff, M, Highland, H M, Morris, A & Hayward, C & Morris, A P 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Mahajan, A, Wessel, J, Willems, S M, Zhao, W, Robertson, N R, Chu, A Y, Gan, W, Kitajima, H, Taliun, D, Rayner, N W, Guo, X, Lu, Y, Li, M, Jensen, R A, Hu, Y, Huo, S, Lohman, K K, Zhang, W, Cook, J P, Prins, B P, Flannick, J, Grarup, N, Trubetskoy, V V, Kravic, J, Kim, Y J, Rybin, D V, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, T V, Marten, J, Li, J, Smith, A V, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, J F, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, L F, Graff, M, Highland, H M, Justice, A E, Liu, D J, Marouli, E, Peloso, G M, Warren, H R, ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Afaq, S, Afzal, S, Ahlqvist, E, Almgren, P, Amin, N, Bang, L B, Bertoni, A G, Bombieri, C, Bork-Jensen, J, Brandslund, I, Brody, J A, Burtt, N P, Canouil, M, Chen, Y-D I, Cho, Y S, Christensen, C, Eastwood, S V, Eckardt, K-U, Fischer, K, Gambaro, G, Giedraitis, V, Grove, M L, de Haan, H G, Hackinger, S, Hai, Y, Han, S, Tybjærg-Hansen, A, Hivert, M-F, Isomaa, B, Jäger, S, Jørgensen, M E, Jørgensen, T, Käräjämäki, A, Kim, B-J, Kim, S S, Koistinen, H A, Kovacs, P, Kriebel, J, Kronenberg, F, Läll, K, Lange, L A, Lee, J-J, Lehne, B, Li, H, Lin, K-H, Linneberg, A, Liu, C-T, Liu, J, Loh, M, Mägi, R, Mamakou, V, McKean-Cowdin, R, Nadkarni, G, Neville, M, Nielsen, S F, Ntalla, I, Peyser, P A, Rathmann, W, Rice, K, Rich, S S, Rode, L, Rolandsson, O, Schönherr, S, Selvin, E, Small, K S, Stančáková, A, Surendran, P, Taylor, K D, Teslovich, T M, Thorand, B, Thorleifsson, G, Tin, A, Tönjes, A, Varbo, A, Witte, D R, Wood, A R, Yajnik, P, Yao, J, Yengo, L, Young, R, Amouyel, P, Boeing, H, Boerwinkle, E, Bottinger, E P, Chowdhury, R, Collins, F S, Dedoussis, G, Dehghan, A, Deloukas, P, Ferrario, M M, Ferrieres, J, Florez, J C, Frossard, P, Gudnason, V, Harris, T B, Heckbert, S R, Howson, J M M, Ingelsson, M, Kathiresan, S, Kee, F, Kuusisto, J, Langenberg, C, Launer, L J, Lindgren, C M, Männistö, S, Meitinger, T, Melander, O, Mohlke, K L, Moitry, M, Morris, A P, Murray, A D, de Mutsert, R, Orho-Melander, M, Owen, K R, Perola, M, Peters, A, Province, M A, Rasheed, A, Ridker, P M, Rivadineira, F, Rosendaal, F R, Rosengren, A H, Salomaa, V, Sheu, W H-H, Sladek, R, Willer, C J, Blüher, M, Butterworth, A S, Chambers, J C, Chasman, D I, Danesh, J, van Duijn, C M, Dupuis, J, Franco, O H, Franks, P W, Froguel, P, Grallert, H, Groop, L, Kardia, S L R, Karpe, F, Kooner, J S, Köttgen, A, Kuulasmaa, K, Laakso, M, Lin, X, Lind, L, Liu, Y, Loos, R J F, Marchini, J, Metspalu, A, Mook-Kanamori, D O, Nordestgaard, B G, Palmer, C N A, Pankow, J S, Pedersen, O, Psaty, B M, Rauramaa, R, Sattar, N, Schulze, M B, Soranzo, N, Spector, T D, Stefansson, K, Stumvoll, M, Thorsteinsdottir, U, Tuomi, T, Tuomilehto, J, Wareham, N J, Wilson, J G, Zeggini, E, Scott, R A, Barroso, I, Frayling, T M, Goodarzi, M O, Meigs, J B, Boehnke, M, Saleheen, D, Morris, A P, Rotter, J I & McCarthy, M I 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
ExomeBP Consortium 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Nature Genetics
Nat. Genet. 50, 559-571 (2018)
NATURE GENETICS
ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Witte, D R & Hansen, T 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Nature genetics
Nature Genetics, 50(4), 559-+. Nature Publishing Group
Nature Genetics, 50(4), 559
Mahajan, A, Wessel, J, Willems, S M, Zhao, W, Robertson, N R, Chu, A Y, Gan, W, Kitajima, H, Taliun, D, Rayner, N W, Guo, X, Lu, Y, Li, M, Jensen, R A, Hu, Y, Huo, S, Lohman, K K, Zhang, W, Cook, J P, Prins, B P, Flannick, J, Grarup, N, Trubetskoy, V V, Kravic, J, Kim, Y J, Rybin, D V, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, T V, Marten, J, Li, J, Smith, A V, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, J F, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, L F, Graff, M, Highland, H M, Morris, A & Hayward, C & Morris, A P 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Mahajan, A, Wessel, J, Willems, S M, Zhao, W, Robertson, N R, Chu, A Y, Gan, W, Kitajima, H, Taliun, D, Rayner, N W, Guo, X, Lu, Y, Li, M, Jensen, R A, Hu, Y, Huo, S, Lohman, K K, Zhang, W, Cook, J P, Prins, B P, Flannick, J, Grarup, N, Trubetskoy, V V, Kravic, J, Kim, Y J, Rybin, D V, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, T V, Marten, J, Li, J, Smith, A V, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, J F, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, L F, Graff, M, Highland, H M, Justice, A E, Liu, D J, Marouli, E, Peloso, G M, Warren, H R, ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Afaq, S, Afzal, S, Ahlqvist, E, Almgren, P, Amin, N, Bang, L B, Bertoni, A G, Bombieri, C, Bork-Jensen, J, Brandslund, I, Brody, J A, Burtt, N P, Canouil, M, Chen, Y-D I, Cho, Y S, Christensen, C, Eastwood, S V, Eckardt, K-U, Fischer, K, Gambaro, G, Giedraitis, V, Grove, M L, de Haan, H G, Hackinger, S, Hai, Y, Han, S, Tybjærg-Hansen, A, Hivert, M-F, Isomaa, B, Jäger, S, Jørgensen, M E, Jørgensen, T, Käräjämäki, A, Kim, B-J, Kim, S S, Koistinen, H A, Kovacs, P, Kriebel, J, Kronenberg, F, Läll, K, Lange, L A, Lee, J-J, Lehne, B, Li, H, Lin, K-H, Linneberg, A, Liu, C-T, Liu, J, Loh, M, Mägi, R, Mamakou, V, McKean-Cowdin, R, Nadkarni, G, Neville, M, Nielsen, S F, Ntalla, I, Peyser, P A, Rathmann, W, Rice, K, Rich, S S, Rode, L, Rolandsson, O, Schönherr, S, Selvin, E, Small, K S, Stančáková, A, Surendran, P, Taylor, K D, Teslovich, T M, Thorand, B, Thorleifsson, G, Tin, A, Tönjes, A, Varbo, A, Witte, D R, Wood, A R, Yajnik, P, Yao, J, Yengo, L, Young, R, Amouyel, P, Boeing, H, Boerwinkle, E, Bottinger, E P, Chowdhury, R, Collins, F S, Dedoussis, G, Dehghan, A, Deloukas, P, Ferrario, M M, Ferrieres, J, Florez, J C, Frossard, P, Gudnason, V, Harris, T B, Heckbert, S R, Howson, J M M, Ingelsson, M, Kathiresan, S, Kee, F, Kuusisto, J, Langenberg, C, Launer, L J, Lindgren, C M, Männistö, S, Meitinger, T, Melander, O, Mohlke, K L, Moitry, M, Morris, A P, Murray, A D, de Mutsert, R, Orho-Melander, M, Owen, K R, Perola, M, Peters, A, Province, M A, Rasheed, A, Ridker, P M, Rivadineira, F, Rosendaal, F R, Rosengren, A H, Salomaa, V, Sheu, W H-H, Sladek, R, Willer, C J, Blüher, M, Butterworth, A S, Chambers, J C, Chasman, D I, Danesh, J, van Duijn, C M, Dupuis, J, Franco, O H, Franks, P W, Froguel, P, Grallert, H, Groop, L, Kardia, S L R, Karpe, F, Kooner, J S, Köttgen, A, Kuulasmaa, K, Laakso, M, Lin, X, Lind, L, Liu, Y, Loos, R J F, Marchini, J, Metspalu, A, Mook-Kanamori, D O, Nordestgaard, B G, Palmer, C N A, Pankow, J S, Pedersen, O, Psaty, B M, Rauramaa, R, Sattar, N, Schulze, M B, Soranzo, N, Spector, T D, Stefansson, K, Stumvoll, M, Thorsteinsdottir, U, Tuomi, T, Tuomilehto, J, Wareham, N J, Wilson, J G, Zeggini, E, Scott, R A, Barroso, I, Frayling, T M, Goodarzi, M O, Meigs, J B, Boehnke, M, Saleheen, D, Morris, A P, Rotter, J I & McCarthy, M I 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
ExomeBP Consortium 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Nature Genetics
Nat. Genet. 50, 559-571 (2018)
NATURE GENETICS
ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Witte, D R & Hansen, T 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Nature genetics
Nature Genetics, 50(4), 559-+. Nature Publishing Group
Nature Genetics, 50(4), 559
Identification of coding variant associations for complex diseases offers a direct route to biological insight, but is dependent on appropriate inference concerning the causal impact of those variants on disease risk. We aggregated coding variant dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ef38d341d4079e9196cb70cb035e2c
https://pure.au.dk/portal/da/publications/refining-the-accuracy-of-validated-target-identification-through-coding-variant-finemapping-in-type-2-diabetes(c1213cf4-47ab-49e6-b8e6-e3a85d879ef4).html
https://pure.au.dk/portal/da/publications/refining-the-accuracy-of-validated-target-identification-through-coding-variant-finemapping-in-type-2-diabetes(c1213cf4-47ab-49e6-b8e6-e3a85d879ef4).html
Autor:
Kim M. Gooding, Faisel Khan, Kunihiko Aizawa, Jan Nilsson, Margaretha Persson, Francesco Casanova, Harry Björkbacka, Michaela Kozakova, Phillip E. Gates, Helen M. Colhoun, Carlo Palombo, Helen C. Looker, Jasmina Kravic, S. Pinnola, Cecilia Kennbäck, Angela C. Shore, Gerd Östling, Andrea Natali, Jill J. F. Belch, Fiona Dove, Elena Venturi, Isabel Gonçalves
Publikováno v:
2018, ' Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes : The SUMMIT VIP Study ', Diabetes Care, vol. 41, no. 10, pp. 2212-2219 . https://doi.org/10.2337/dc18-0185
OBJECTIVE Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c3e06d88555752833705d1b0aba37d
http://hdl.handle.net/11568/926212
http://hdl.handle.net/11568/926212
Autor:
Jasmina Kravic, Margarita Alonso, Francesco Sambo, Enrico Longato, Bo Isomaa, Leif Groop, Jaakko Tuomilehto, Claudio Cobelli, Andrea Facchinetti, Liisa Hakaste, Rafael Gabriel, Tiinamaija Tuomi, Barbara Di Camillo
Publikováno v:
European journal of endocrinology. 178(4)
ObjectiveType 2 diabetes arises from the interaction of physiological and lifestyle risk factors. Our objective was to develop a model for predicting the risk of T2D, which could use various amounts of background information.Research design and metho
Autor:
Leif Groop, Jasmina Kravic, Gopal Peddinti, Tero Aittokallio, Beverley Balkau, Jeff Cobb, Loic Yengo, Philippe Froguel, Tiinamaija Tuomi
Publikováno v:
Diabetologia
Peddinti, G, Cobb, J, Yengo, L, Froguel, P, Kravić, J, Balkau, B, Tuomi, T, Aittokallio, T & Groop, L 2017, ' Early metabolic markers identify potential targets for the prevention of type 2 diabetes ', Diabetologia, vol. 60, no. 9, pp. 1740-1750 . https://doi.org/10.1007/s00125-017-4325-0
Peddinti, G, Cobb, J, Yengo, L, Froguel, P, Kravić, J, Balkau, B, Tuomi, T, Aittokallio, T & Groop, L 2017, ' Early metabolic markers identify potential targets for the prevention of type 2 diabetes ', Diabetologia, vol. 60, no. 9, pp. 1740-1750 . https://doi.org/10.1007/s00125-017-4325-0
Aims/hypothesis The aims of this study were to evaluate systematically the predictive power of comprehensive metabolomics profiles in predicting the future risk of type 2 diabetes, and to identify a panel of the most predictive metabolic markers. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ab3165a342f3ae1d0daba4d3da011c
http://hdl.handle.net/10044/1/49756
http://hdl.handle.net/10044/1/49756
Autor:
Tazeen H. Jafar, Lars Lind, Peter Almgren, Wendy Winckler, Eitaro Nakashima, Young Min Cho, Annette Peters, Rona J. Strawbridge, Ananda R. Wickremasinghe, Katharine R. Owen, Lee-Ming Chuang, Tien-Jyun Chang, Graeme I. Bell, James B. Meigs, Bill Musk, Timo A. Lakka, Elin Grundberg, Wei Lu, Sarah Edkins, George Dedoussis, Weiping Jia, Danish Saleheen, Suthesh Sivapalaratnam, Maria Samuel, Tien Yin Wong, Lu Qi, Pierre Fontanillas, Momoko Horikoshi, Jirong Long, Abdul Basit, Anubha Mahajan, Andrew T. Hattersley, Markus M. Nöthen, Denis Rybin, Inger Njølstad, S. Krithika, Miguel Cruz, Delilah Zabaneh, Leena Peltonen, Jasmina Kravic, Sangsoo Kim, David Couper, Lori L. Bonnycastle, Heather M. Stringham, Yi-Cheng Chang, Paul Elliott, Eric J.G. Sijbrands, Nita G. Forouhi, Alena Stančáková, Ghazala Mirza, Robert W. Lawrence, Ruth J. F. Loos, Norman Klopp, Shiro Maeda, Martina Müller-Nurasyid, Jer-Yuarn Wu, Jianjun Liu, Kee Seng Chia, Elodie Eury, Loukianos S. Rallidis, Timothy M. Frayling, Ken Yamamoto, David Altshuler, Gunnar Sigurosson, Harald Grallert, Jackie F. Price, Barbara Thorand, Jouko Saramies, Malene M. Kristensen, Sonali Pechlivanis, Inês Barroso, Jong-Young Lee, Melissa Parkin, Josée Dupuis, Stéphane Lobbens, Jesús Kumate, Elena Tremoli, Sudhir Kowlessur, Xueling Sim, Norihiro Kato, Philippe Froguel, Kathleen Stirrups, Eero Lindholm, Alex S. F. Doney, Andres Metspalu, Yu-Tang Gao, Roman Wennauer, Xiao-Ou Shu, Marilyn C. Cornelis, Veikko Salomaa, Nanette R. Lee, Johanna Kuusisto, Caroline S. Fox, Man Li, James Scott, Wing-Yee So, Andrew R. Wood, Inga Prokopenko, Oddgeir L. Holmen, Tin Aung, Ryoichi Takayanagi, Chen Suo, Hara Kazuo, Carl G. P. Platou, Ann M. Kelly, Teresa Ferreira, Karl-Heinz Jöckel, Wei-Yen Lim, James F. Wilson, Tom Forsén, Qi Sun, Valur Emilsson, Gonçalo R. Abecasis, Fan Zhang, Timo Saaristo, Harry Campbell, Ying Wu, Mark Seielstad, Wei Zheng, Han Chen, Stavroula Kanoni, Yuqian Bao, Jose C. Florez, Wan Ting Tay, Ronald C. WMa, Gerald Steinbach, Min Jin Go, Rong Zhang, Junbin Liang, Vasiliki Lagou, Leif Groop, Emil Rehnberg, Nabi Shah, Weihua Zhang, Yun Li, Bengt Sennblad, Olle Melander, Nancy L. Pedersen, Muhammed Islam, Jaakko Tuomilehto, Young Jin Kim, Richard N. Bergman, Juliana C.N. Chan, Eleftheria Zeggini, Andrew D. Johnson, Kees Hovingh, Joban Sehmi, Rainer Rauramaa, Satu Männistö, Reedik Mägi, Samuel Liju, Mingyu Yang, Ayellet V. Segrè, Noël P. Burtt, Mozhgan Dorkhan, Beverley Balkau, Neelam Hassanali, Hyun Min Kang, Fabrizio Veglia, Eeva Korpi-Hyövälti, Loic Yengo, Elizabeth J. Rossin, Angela Silveira, Maggie C.Y. Ng, Yuan-Tsong Chen, Anders Hamsten, David R. Matthews, Mark J. Caulfield, Emmi Tikkanen, Tanya M. Teslovich, John R. B. Perry, Karen L. Mohlke, Sarah E. Hunt, Soo Heon Kwak, Jorge Escobedo, Christopher J. Groves, Ulf de Faire, Jeremy B M Jowett, Gudmar Thorleifsson, Michael Roden, Evelin Mihailov, Viswanathan Mohan, Craig L. Hanis, Thomas WMühleisen, Congrong Wang, Sonia Shah, Kyle J. Gaulton, Jaspal S. Kooner, Jiro Nakamura, Mustafa Atalay, Linda S. Adair, S Wiltshire, Tõnu Esko, Anna Jonsson, Antigone S. Dimas, Karin Leander, Li Ching Chang, George B. Grant, Bo Isomaa, Anne U. Jackson, Claudia Langenberg, Kristian Hveem, Yoon Shin Cho, Astradur B. Hreidarsson, Xu Wang, Keizo Ohnaka, Alexandra C. Nica, Simon D. Rees, Pau Navarro, Sekar Kathiresan, Rob M. van Dam, Zafar I. Hydrie, Bok Ghee Han, Francis S. Collins, Fuu Jen Tsai, Unnur Thorsteinsdottir, Ross M. Fraser, Caroline Hayward, Cornelia M. van Duijn, Samuli Ripatti, Mieke D. Trip, Hyung Lae Kim, Rafn Benediktsson, Candace Guiducci, Bruna Gigante, Kyong Soo Park, Wen Hong L. Kao, Tom Wilsgaard, Leena Kinnunen, John Danesh, Alan James, Alan R. Shuldiner, Mitsuhiro Yokota, Jen Mai Lee, Kari Stefansson, Erik Ingelsson, Colin N. A. Palmer, David J. Hunter, Paul Zimmet, Manickam Chidambaram, Sirkka Keinänen-Kiukaanniemi, Laura J. Scott, Susanne Moebus, Benjamin F. Voight, Wolfgang Rathmann, Hassan Khan, Thomas Illig, Prasad Katulanda, Christian Gieger, Andrew D. Morris, Yik Ying Teo, Andrew P. Morris, Venkatesan Radha, N. William Rayner, Johan G. Eriksson, Christian Dina, Igor Rudan, Sailaja Vedantam, Cheng Hu, James S. Pankow, Ann-Christine Syvänen, Karl Gertow, Valeriya Lyssenko, Guillaume Charpentier, Albert Hofman, Chiea Chuen Khor, Joseph Trakalo, Peter Kraft, Takashi Kadowaki, Qiuyin Cai, John C. Chambers, André G. Uitterlinden, Simon C. Potter, Nicholas J. Wareham, Soumya Raychaudhuri, Jian'an Luan, Tiinamaija Tuomi, Anthony H. Barnett, Juha Saltevo, Robert A. Scott, Valgerdur Steinthorsdottir, Peng Keat Ng, Mark I. McCarthy, Åsa K. Hedman, Kerrin S. Small, Julia Meyer, Frank B. Hu, Cecilia M. Lindgren, Jennifer E. Below, Nancy J. Cox, Jennie Hui, Andrew Crenshaw, Latonya F. Been, Nam H. Cho, Janani Pinidiyapathirage, A. Samad Shera, Bernhard OBoehm, Jason Carey, Augustine Kong, Twee Hee Ong, Philippe M. Frossard, Donald W. Bowden, Toshimasa Yamauchi, Steve E. Humphries, Cordelia Langford, Xinzhong Li, Hiroshi Ikegami, Stéphane Cauchi, Ching-Ti Liu, Michael Boehnke, Peter M. Nilsson, Debashish Das, John Beilby, Robin Young, Christian Herder, Asif Rasheed, Neil Robertson, Raimund Erbel, Fumihiko Takeuchi, Markku Laakso, Esteban J. Parra, Panos Deloukas, Eric Boerwinkle, Adan Valladares-Salgado, Chien-Hsiun Chen, Kay-Tee Khaw, Damiano Baldassarre, Ashok Kumar, E. Shyong Tai, Peter S. Chines, Dharambir KSanghera, Peter Donnelly
Publikováno v:
Nature Genetics, 46(3), 234-+. Nature Publishing Group
Nature genetics
Nature Genetics; Vol 46
Mahajan, A, Go, M J, Zhang, W, Below, J E, Gaulton, K J, Ferreira, T, Horikoshi, M, Johnson, A D, Ng, M C Y, Prokopenko, I, Saleheen, D, Wang, X, Zeggini, E, Abecasis, G R, Adair, L S, Almgren, P, Atalay, M, Aung, T, Baldassarre, D, Balkau, B, Bao, Y, Barnett, A H, Barroso, I, Basit, A, Been, L F, Beilby, J, Bell, G I, Benediktsson, R, Bergman, R N, Boehm, B O, Boerwinkle, E, Bonnycastle, L L, Burtt, N, Cai, Q, Campbell, H, Carey, J, Cauchi, S, Caulfield, M, Chan, J C N, Chang, L-C, Chang, T-J, Chang, Y-C, Fraser, R M, Hayward, C & Morris, A & Navarro, P & Price, J F & Rudan, I & Wilson, J F & Zhang, R 2014, ' Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility ', Nature Genetics, vol. 46, no. 3, pp. 234-244 . https://doi.org/10.1038/ng.2897
Nature Genetics
Nature genetics, 46(3), 234-244. Nature Publishing Group
Nature genetics
Nature Genetics; Vol 46
Mahajan, A, Go, M J, Zhang, W, Below, J E, Gaulton, K J, Ferreira, T, Horikoshi, M, Johnson, A D, Ng, M C Y, Prokopenko, I, Saleheen, D, Wang, X, Zeggini, E, Abecasis, G R, Adair, L S, Almgren, P, Atalay, M, Aung, T, Baldassarre, D, Balkau, B, Bao, Y, Barnett, A H, Barroso, I, Basit, A, Been, L F, Beilby, J, Bell, G I, Benediktsson, R, Bergman, R N, Boehm, B O, Boerwinkle, E, Bonnycastle, L L, Burtt, N, Cai, Q, Campbell, H, Carey, J, Cauchi, S, Caulfield, M, Chan, J C N, Chang, L-C, Chang, T-J, Chang, Y-C, Fraser, R M, Hayward, C & Morris, A & Navarro, P & Price, J F & Rudan, I & Wilson, J F & Zhang, R 2014, ' Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility ', Nature Genetics, vol. 46, no. 3, pp. 234-244 . https://doi.org/10.1038/ng.2897
Nature Genetics
Nature genetics, 46(3), 234-244. Nature Publishing Group
To access publisher's full text version of this article click on the hyperlink at the bottom of the page To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide assoc
Autor:
Jalal Taneera, Erik Renström, Claes Ladenvall, Bo Isomaa, Valeriya Lyssenko, Tiinamaija Tuomi, Anna Jonsson, Leif Groop, Ulrika Krus, Jasmina Kravic, Tarunveer S. Ahluwalia
Publikováno v:
Diabetes; Vol 62
Diabetes
Diabetes
Although meta-analyses of genome-wide association studies have identified >60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information on whether these variants also affect α-cell fun
Autor:
Laura J. Scott, Neil Robertson, Anders Hamsten, Domenico Palli, Susanne Moebus, Bernhard O. Boehm, Gunnar Sigurðsson, Paul W. Franks, C. N. A. Palmer, Sonali Pechlivanis, Katharine R. Owen, Michael E. Reschen, Sarah Edkins, Jason Carey, Christopher A. O’Callaghan, Norman Klopp, Caroline S. Fox, Petter Storm, N. William Rayner, Johan G. Eriksson, Thomas Illig, Anubha Mahajan, Erik Ingelsson, Allan Linneberg, Andrew R. Wood, Oddgeir L. Holmen, Nicola L. Beer, Mark I. McCarthy, Frank B. Hu, Peter Almgren, Heiner Boeing, Peter Donnelly, Carl Platou, Veikko Salomaa, Karl-Heinz Jöcke, Wen-Hong L. Kao, Lori L. Bonnycastle, Denis Rybin, Benjamin F. Voight, Peter Kraft, Inês Barroso, Claudia Langenberg, Teresa Ferreira, Peter Kovacs, Anne Raimondo, Christian Theil Have, Ulf de Faire, Torben Hansen, Han Chen, James B. Meigs, Timothy M. Frayling, Noël P. Burtt, Gerald Steinbach, Eric Boerwinkle, Michael Stumvoll, Stefan Gustafsson, Lars Lind, Andrew D. Morris, Alena Stančáková, Panagiotis Deloukas, Kari Stefansson, Augustine Kong, Hans A. Kestler, Andrew T. Hattersley, Beverley Balkau, Lorenzo Pasquali, Yingchang Lu, Nicola D. Kerrison, George B. Grant, Eeva Korpi-Hyövälti, Steven Wiltshire, Karl Gertow, Jorge Ferrer, Barbara Thorand, Inga Prokopenko, Matthias Blüher, Yvonne T. van der Schouw, Olga McLeod, Oluf Pedersen, Leena Peltonen, Anil Chalisey, Eleftheria Zeggini, Joseph Trakalo, Eric J.G. Sijbrands, Rainer Rauramaa, Guillaume Charpentier, Satu Männistö, Cordelia Langford, Lewin Eisele, Damiano Baldassarre, Lennart C. Karssen, Rona J. Strawbridge, Ghazala Mirza, Peter S. Chines, Roman Wennauer, Sara M. Willems, Erwin P. Bottinger, Timo Saaristo, Stéphane Cauchi, Ching-Ti Liu, Martijn van de Bunt, Valgerdur Steinthorsdottir, David Altshuler, Hyun Min Kang, Michael Boehnke, Jaakko Tuomilehto, Peter M. Nilsson, Kyle J. Gaulton, Jian'an Luan, Loic Yengo, David Couper, Reedik Mägi, Harald Grallert, Simone Wahl, Juha Saltevo, Phoenix Kwan, Cecilia M. Lindgren, Peter Lichtner, Richard N. Bergman, Andrew Crenshaw, João Fadista, Michael Roden, Annette Peters, Robert A. Scott, Unnur Thorsteinsdottir, James S. Pankow, Yeji Lee, Cornelia M. van Duijn, Samuli Ripatti, Francis S. Collins, Stéphane Lobbens, Niels Grarup, Ruth J. F. Loos, Julia Meyer, Marit E. Jørgensen, Christian Herder, Inger Njølstad, John R. B. Perry, Markus M. Nöthen, Man Li, Martina Müller-Nurasyid, Valeriya Lyssenko, Pierre Fontanillas, Michael D. Linderman, Leena Kinnunen, Jana K. Rundle, Elena Tremoli, Marilyn C. Cornelis, Tanya M. Teslovich, Todd Green, Raimund Erbel, Elisabeth M. van Leeuwen, Bengt Sennblad, Olle Melander, Sirkka Keinänen-Kiukaanniemi, Markku Laakso, Eero Lindholm, Alex S. F. Doney, Anke Tönjes, Maija Hassinen, Thomas W. Mühleisen, Gonçalo R. Abecasis, Nancy L. Pedersen, Thomas Sparsø, Johanna Kuusisto, Dorothée Thuillier, Qi Sun, Ian Dunham, Himanshu Chheda, Adam E. Locke, Philippe Froguel, Nicholas J. Wareham, Bruna Gigante, Jose C. Florez, Mozhgan Dorkhan, Omri Gottesman, Liming Liang, Anna Jonsson, Tiinamaija Tuomi, Leif Groop, Steve E. Humphries, Heikki A. Koistinen, Kristian Hveem, Astradur B. Hreidarsson, Jason Flannick, Torben Jørgensen, Clement Ma, Mattias Frånberg, Ewan Birney, Andrew P. Morris, Timo A. Lakka, Rob M. van Dam, Heather M. Stringham, Christian Gieger, Elodie Eury, Konstantin Strauch, Anna L. Gloyn, Rafn Benediktsson, Andres Metspalu, David J. Hunter, Karen L. Mohlke, Gudmar Thorleifsson, Josée Dupuis, Emmi Tikkanen, Christian Fuchsberger, Evelin Mihailov, Christopher J. Groves, Soren K. Thomsen, Tõnu Esko, Anne U. Jackson, Karin Leander, Douglas M. Ruderfer, Nikolay Oskolkov, Sekar Kathiresan, Robert Sladek, Lu Qi, Jasmina Kravic, Carmen Navarro
Publikováno v:
Nature Genetics, 47, 1415. Nature Publishing Group
Nature Genetics, 47(12), 1415-+. Nature Publishing Group
Nature genetics, 47(12), 1415-+. Nature Publishing Group
Gaulton, K J, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Reschen, M E, Mahajan, A, Locke, A E, Rayner, N W, Robertson, N, Scott, R A, Prokopenko, I, Scott, L J, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Frånberg, M, Strawbridge, R J, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, L C, van Leeuwen, E M, Willems, S M, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, S K, Rundle, J K, Beer, N L, van de Bunt, M, Chalisey, A, Kang, H M, Voight, B F, Abecasis, G R, Almgren, P, Baldassarre, D, Jørgensen, M E, Hansen, T & DIAGRAM Consortium 2015, ' Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci ', Nature Genetics, vol. 47, no. 12, pp. 1415-1425 . https://doi.org/10.1038/ng.3437
Nature Genetics
Gaulton, K J, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Reschen, M E, Mahajan, A, Locke, A, William Rayner, N, Robertson, N, Scott, R A, Prokopenko, I, Scott, L J, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Frånberg, M, Strawbridge, R J, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, L C, van Leeuwen, E M, Willems, S M, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, S K, Rundle, J K, Beer, N L, van de Bunt, M, Chalisey, A, Kang, H M, Voight, B F, Abecasis, G R, Almgren, P, Baldassarre, D, Balkau, B, Jørgensen, T & DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium 2015, ' Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci ', Nature Genetics, vol. 47, no. 12, pp. 1415-1425 . https://doi.org/10.1038/ng.3437
Nature genetics
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Genetics, 47(12), 1415-+. Nature Publishing Group
Nature genetics, 47(12), 1415-+. Nature Publishing Group
Gaulton, K J, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Reschen, M E, Mahajan, A, Locke, A E, Rayner, N W, Robertson, N, Scott, R A, Prokopenko, I, Scott, L J, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Frånberg, M, Strawbridge, R J, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, L C, van Leeuwen, E M, Willems, S M, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, S K, Rundle, J K, Beer, N L, van de Bunt, M, Chalisey, A, Kang, H M, Voight, B F, Abecasis, G R, Almgren, P, Baldassarre, D, Jørgensen, M E, Hansen, T & DIAGRAM Consortium 2015, ' Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci ', Nature Genetics, vol. 47, no. 12, pp. 1415-1425 . https://doi.org/10.1038/ng.3437
Nature Genetics
Gaulton, K J, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Reschen, M E, Mahajan, A, Locke, A, William Rayner, N, Robertson, N, Scott, R A, Prokopenko, I, Scott, L J, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Frånberg, M, Strawbridge, R J, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, L C, van Leeuwen, E M, Willems, S M, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, S K, Rundle, J K, Beer, N L, van de Bunt, M, Chalisey, A, Kang, H M, Voight, B F, Abecasis, G R, Almgren, P, Baldassarre, D, Balkau, B, Jørgensen, T & DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium 2015, ' Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci ', Nature Genetics, vol. 47, no. 12, pp. 1415-1425 . https://doi.org/10.1038/ng.3437
Nature genetics
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
To access publisher's full text version of this article click on the hyperlink at the bottom of the page We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0b5ee13e5230169a934120dd03c1e8
https://dspace.library.uu.nl/handle/1874/332306
https://dspace.library.uu.nl/handle/1874/332306
Autor:
Francesco Sambo, Leif Groop, Giuseppe Fico, Andrea Facchinetti, Liisa Hakaste, Tuomi Tiinamaija, Rafael Gabriel, Jasmina Kravic, Claudio Cobelli, Barbara Di Camillo, Jaakko Tuomilehto
Publikováno v:
Artificial Intelligence in Medicine ISBN: 9783319195506
AIME
AIME
We propose a novel Bayesian network tool to model the probabilistic relations between a set of type 2 diabetes risk factors. The tool can be used for probabilistic reasoning and for imputation of missing values among risk factors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17db63fa266e9ad57a1ec58b86b07ef0
http://hdl.handle.net/11577/3225283
http://hdl.handle.net/11577/3225283
Autor:
Tom Forsén, Lars Lind, Shobha Potluri, Leif Groop, Yik Ying Teo, Andrew P. Morris, Frank Burslem, Jason Flannick, Torben Jørgensen, Tanya M. Teslovich, Noël P. Burtt, Jaspal S. Kooner, Patrick Sulem, Nicola L. Beer, Sekar Kathiresan, Ivan Brandslund, Heather M. Stringham, James G. Wilson, Jeff K. Trimmer, Valgerdur Steinthorsdottir, Cecilia M. Lindgren, Zachary Dymek, Yossi Farjoun, Tim Rolph, Unnur Thorsteinsdottir, Karen L. Mohlke, Jaakko Tuomilehto, John C. Chambers, Gudmar Thorleifsson, Rasmus Ribel-Madsen, Anubha Mahajan, Christian Fuchsberger, Jasmina Kravic, Kari Stefansson, Benjamin F. Voight, Craig L. Hanis, John Blangero, Veikko Salomaa, Desiree Douglas, Rafn Benediktsson, Benjamin Glaser, David R. Cox, Ann Marie Richard, Torben Hansen, Hanna Skärstrand, Gil Atzmon, Pål R. Njølstad, Suzanne B.R. Jacobs, Erik Ingelsson, Bo Isomaa, Yoon Shin Cho, Ayellet V. Segrè, Julia Brosnan, Thomas Meitinger, David Altshuler, Kristian Hveem, Astradur B. Hreidarsson, Pierre Fontanillas, Gisli Masson, Daniel F. Gudbjartsson, Cramer Christensen, Tiinamaija Tuomi, Augustine Kong, Fariba Vaziri-Sani, Anders Molven, Rainer Rauramaa, Niels Grarup, Stacey Gabriel, Michael Boehnke, Ravindranath Duggirala, Donald W. Bowden, Oluf Pedersen, Marit E. Jørgensen, Markku Laakso, Jong-Young Lee, Stefan Johansson, E. Shyong Tai, Allan Linneberg, Mark I. McCarthy, Timothy Fennell
Publikováno v:
Flannick, J, Thorleifsson, G, Beer, N L, Jacobs, S B R, Grarup, N, Burtt, N P, Mahajan, A, Fuchsberger, C, Atzmon, G, Benediktsson, R, Blangero, J, Bowden, D W, Brandslund, I, Brosnan, J, Burslem, F, Chambers, J, Cho, Y S, Christensen, C, Douglas, D A, Duggirala, R, Dymek, Z, Farjoun, Y, Fennell, T, Fontanillas, P, Forsen, T, Gabriel, S, Glaser, B, Gudbjartsson, D F, Hanis, C, Hansen, T, Hreidarsson, A B, Hveem, K, Ingelsson, E, Isomaa, B, Johansson, S, Jorgensen, T, Jorgensen, M E, Kathiresan, S, Kong, A, Kooner, J, Kravic, J, Laakso, M, Lee, J Y, Lind, L, Lindgren, C M, Linneberg, A, Masson, G, Meitinger, T, Mohlke, K L, Molven, A, Morris, A P, Potluri, S, Rauramaa, R, Ribel-Madsen, R, Richard, A M, Rolph, T, Saloemaa, V, Segre, A V, Skarstrand, H, Steinthorsdottir, V, Stringham, H M, Sulem, P, Tai, E S, Teo, Y Y, Teslovich, T, Thorsteinsdottir, U, Trimmer, J K, Tuomi, T, Tuomilehto, J, Vaziri-Sani, F, Voight, B F, Voight, B F, Boehnke, M, McCarthy, M I, Njolstad, P R, Pedersen, O, Groop, L, Cox, D R, Stefansson, K, Altshuler, D, Go, T D C & Consortium, T D-G 2014, ' Loss-of-function mutations in SLC30A8 protect against type 2 diabetes ', Nature Genetics, vol. 46, no. 4, pp. 357-363 . https://doi.org/10.1038/ng.2915
Nature Genetics; Vol 46
Flannick, J, Thorleifsson, G, Beer, N L, Jacobs, S B R, Grarup, N, Burtt, N P, Mahajan, A, Fuchsberger, C, Atzmon, G, Benediktsson, R, Blangero, J, Bowden, D W, Brandslund, I, Brosnan, J, Burslem, F, Chambers, J, Cho, Y S, Christensen, C, Douglas, D A, Duggirala, R, Dymek, Z, Farjoun, Y, Fennell, T, Fontanillas, P, Forsén, T, Gabriel, S, Glaser, B, Gudbjartsson, D F, Hanis, C, Hansen, T, Hreidarsson, A B, Hveem, K, Ingelsson, E, Isomaa, B, Johansson, S, Jørgensen, T, Jørgensen, M E, Kathiresan, S, Kong, A, Kooner, J, Kravic, J, Laakso, M, Lee, J Y, Lind, L, Lindgren, C M, Linneberg, A, Masson, G, Meitinger, T, Mohlke, K L, Molven, A, Morris, A P, Potluri, S, Rauramaa, R, Ribel-Madsen, R, Richard, A M, Rolph, T, Salomaa, V, Segrè, A V, Skärstrand, H, Steinthorsdottir, V, Stringham, H M, Sulem, P, Tai, E S, Teo, Y Y, Teslovich, T, Thorsteinsdottir, U, Trimmer, J K, Tuomi, T, Tuomilehto, J, Vaziri-Sani, F, Voight, B F, Wilson, J G, Boehnke, M, McCarthy, M I, Njølstad, P R, Pedersen, O, Groop, L, Cox, D R, Stefansson, K & Altshuler, D 2014, ' Loss-of-function mutations in SLC30A8 protect against type 2 diabetes ', Nature Genetics, vol. 46, no. 4, pp. 357-363 . https://doi.org/10.1038/ng.2915
Nature Genetics; Vol 46
Flannick, J, Thorleifsson, G, Beer, N L, Jacobs, S B R, Grarup, N, Burtt, N P, Mahajan, A, Fuchsberger, C, Atzmon, G, Benediktsson, R, Blangero, J, Bowden, D W, Brandslund, I, Brosnan, J, Burslem, F, Chambers, J, Cho, Y S, Christensen, C, Douglas, D A, Duggirala, R, Dymek, Z, Farjoun, Y, Fennell, T, Fontanillas, P, Forsén, T, Gabriel, S, Glaser, B, Gudbjartsson, D F, Hanis, C, Hansen, T, Hreidarsson, A B, Hveem, K, Ingelsson, E, Isomaa, B, Johansson, S, Jørgensen, T, Jørgensen, M E, Kathiresan, S, Kong, A, Kooner, J, Kravic, J, Laakso, M, Lee, J Y, Lind, L, Lindgren, C M, Linneberg, A, Masson, G, Meitinger, T, Mohlke, K L, Molven, A, Morris, A P, Potluri, S, Rauramaa, R, Ribel-Madsen, R, Richard, A M, Rolph, T, Salomaa, V, Segrè, A V, Skärstrand, H, Steinthorsdottir, V, Stringham, H M, Sulem, P, Tai, E S, Teo, Y Y, Teslovich, T, Thorsteinsdottir, U, Trimmer, J K, Tuomi, T, Tuomilehto, J, Vaziri-Sani, F, Voight, B F, Wilson, J G, Boehnke, M, McCarthy, M I, Njølstad, P R, Pedersen, O, Groop, L, Cox, D R, Stefansson, K & Altshuler, D 2014, ' Loss-of-function mutations in SLC30A8 protect against type 2 diabetes ', Nature Genetics, vol. 46, no. 4, pp. 357-363 . https://doi.org/10.1038/ng.2915
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b7f58ef7f0659b2cc5ed7dd42c8306
https://portal.findresearcher.sdu.dk/da/publications/49910ede-b220-458f-a961-6e9f6447521c
https://portal.findresearcher.sdu.dk/da/publications/49910ede-b220-458f-a961-6e9f6447521c