Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

Autor: Sergio Rodriguez-Cuenca, Gary A. Churchill, Antonio Vidal-Puig, Maximilian Zeyda, Nicholas M. Morton, Annalisa Gastaldello, Jasmina Beltram, Scott P. Webster, Gregor Gorjanc, Aila Saari, Thomas M. Stulnig, Simon Horvat, Vilmundur Gudnason, Roderick N. Carter, Matthew T G Gibbins, José Manuel Fernández-Real, Jonathan R. Seckl, Steven C. Munger, Clare McFadden, Gregorio Naredo, Martin E. Barrios-Llerena, Donald R. Dunbar, Christopher J Kenyon, Zhao V. Wang, Alexander F. Howie, Lynne Ramage, José María Moreno-Navarrete, Karen L. Svenson, Brian R. Walker, Valur Emilsson, Petra Sipilä, Zoi Michailidou, Rhona Aird

Publikováno v: Morton, N M, Beltram, J, Carter, R N, Michailidou, Z, Gorjanc, G, McFadden, C, Barrios-Llerena, M E, Rodriguez-Cuenca, S, Gibbins, M T G, Aird, R E, Moreno-Navarrete, J M, Munger, S C, Svenson, K L, Gastaldello, A, Ramage, L, Naredo, G, Zeyda, M, Wang, Z V, Howie, A F, Saari, A, Sipilä, P, Stulnig, T M, Gudnason, V, Kenyon, C J, Seckl, J R, Walker, B R, Webster, S P, Dunbar, D R, Churchill, G A, Vidal-Puig, A, Fernandez-Real, J M, Emilsson, V & Horvat, S 2016, ' Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness ', Nature Medicine, vol. 22, no. 7, pp. 771-779 . https://doi.org/10.1038/nm.4115
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© Nature Medicine, 2016, vol. 22, p. 771-779
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The discovery of genetic mechanisms for resistance to obesity and diabetes may illuminate new therapeutic strategies for the treatment of this global health challenge. We used the polygenic 'lean' mouse model, which has been selected for low adiposit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d97883a5e7915270071cddd2f0f72e6
https://hdl.handle.net/2072/372198

Construction of an integrative regulatory element and variation map of the murine Tst locus

Autor: Simon Horvat, Nicholas M. Morton, Jasmina Beltram, Tanja Kunej

Publikováno v: BMC Genetics
Beltram, J, Morton, N M, Kunej, T & Horvat, S 2016, ' Construction of an integrative regulatory element and variation map of the murine Tst locus ', BMC Genetics, vol. 17, no. 1 . https://doi.org/10.1186/s12863-016-0381-6

Background Given the abundance of new genomic projects and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challenging task of how to efficiently integrate all current genomic information. The objective of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5504be24779e1f9986660f2a8c0a03b2
https://doi.org/10.1186/s12863-016-0381-6

DEPTOR promoter genetic variants and insulin resistance in obese children and adolescents

Autor: Jernej, Kovač, Tamara, Šutuš Temovski, Tomaž, Rozmarič, Simon, Horvat, Jasmina, Beltram, Katarina, Trebušak Podkrajšek, Tadej, Battelino, Primož, Kotnik

Publikováno v: Pediatric diabetes. 18(2)

Insulin resistance (IR) is one of the major metabolic complications of obesity in children and adolescents. DEP domain-containing mammalian target of rapamycin interacting protein (DEPTOR) is involved in downstream insulin signaling and DEPTOR's effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::798a6a48fb20cda909ab0669ad5b1d83
https://pubmed.ncbi.nlm.nih.gov/26871578