CcpA- and Shm2-Pulsed Myeloid Dendritic Cells Induce T-Cell Activation and Enhance the Neutrophilic Oxidative Burst Response to Aspergillus fumigatus

Autor: Lukas Page, Julia Wallstabe, Jasmin Lother, Maximilian Bauser, Olaf Kniemeyer, Lea Strobel, Vera Voltersen, Janka Teutschbein, Peter Hortschansky, Charles Oliver Morton, Axel A. Brakhage, Max Topp, Hermann Einsele, Sebastian Wurster, Juergen Loeffler

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Aspergillus fumigatus causes life-threatening opportunistic infections in immunocompromised patients. As therapeutic outcomes of invasive aspergillosis (IA) are often unsatisfactory, the development of targeted immunotherapy remains an important goal

Externí odkaz: https://doaj.org/article/207287c8a5c445f8b26ff8097c93cc97

Human and Murine Innate Immune Cell Populations Display Common and Distinct Response Patterns during Their In Vitro Interaction with the Pathogenic Mold Aspergillus fumigatus

Autor: Anna-Maria Hellmann, Jasmin Lother, Sebastian Wurster, Manfred B. Lutz, Anna Lena Schmitt, Charles Oliver Morton, Matthias Eyrich, Kristin Czakai, Hermann Einsele, Juergen Loeffler

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Aspergillus fumigatus is the main cause of invasive fungal infections occurring almost exclusively in immunocompromised patients. An improved understanding of the initial innate immune response is key to the development of better diagnostic tools and

Externí odkaz: https://doaj.org/article/dc4dc2d93b1540218a497c00802bad0e

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus

Autor: Maria Strassburger, Jasmin Lother, Sven Krappmann, Vera Voltersen, Hermann Einsele, Sandor Nietzsche, Alexander Scheffold, Petra Bacher, Olaf Kniemeyer, Kerstin Hünniger, Scott G. Filler, Thorsten Heinekamp, Peter Hortschansky, Thomas Krüger, Franziska Schmidt, Esther Weiss, Oliver Kurzai, Axel A. Brakhage, Jürgen Löffler, Hong Liu, Sahra Herrmann, Utz Reichard, Matthew G. Blango

Publikováno v: Voltersen, V; Blango, MG; Herrmann, S; Schmidt, F; Heinekamp, T; Strassburger, M; et al.(2018). Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus. MBIO, 9(5). doi: 10.1128/mBio.01557-18. UCLA: Retrieved from: http://www.escholarship.org/uc/item/56d76073
mBio, vol 9, iss 5
mBio, Vol 9, Iss 5 (2018)
mBio, Vol 9, Iss 5, p e01557-18 (2018)

Aspergillus fumigatus is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome profiling to date of A.fumigatus resting conidia, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831b88be240aa060b04782ea48d934ce
https://doi.org/10.1128/mbio.01557-18

Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus

Autor: Sven Krappmann, Charles Oliver Morton, Juergen Loeffler, Mike Hasenberg, Oliver Kurzai, Jasmin Lother, Maria Bouzani, Hermann Einsele, Matthias Gunzer, Tanja Breitschopf

Publikováno v: International journal of medical microbiology : IJMM. 304(8)

The mould Aspergillus fumigatus is primarily an opportunistic pathogen of immunocompromised patients. Once fungal spores have been inhaled they encounter cells of the innate immune system, which include dendritic cells (DCs). DCs are the key antigen-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fb3d63e6df26ede938ec8168b85d40
https://pubmed.ncbi.nlm.nih.gov/25200858