CXCR4--A Prognostic and Clinicopathological Biomarker for Pancreatic Ductal Adenocarcinoma: A Meta-Analysis.

Autor: Andreas Krieg, Jasmin C Riemer, Leila A Telan, Helmut E Gabbert, Wolfram T Knoefel

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130192 (2015)

Adenocarcinomas of the pancreatic duct (PDAC) are characteristically aggressive tumors that are extremely challenging to treat as curative surgical resection, the definitive treatment, is seldom possible. Regretably, most patients are diagnosed with

Externí odkaz: https://doaj.org/article/ae3f0eec78604ad1a72eaca200d9b879

Diagnostic challenges in a child with early onset desmoplastic medulloblastoma and homozygous variants in MSH2 and MSH6

Autor: Triantafyllia Brozou, Olivier Lascols, Michaela Kuhlen, Chrystelle Colas, Julia Taeubner, Christine Fauth, Jessica I. Hoell, Katharina Wimmer, Joerg Felsberg, Jasmin C. Riemer, Sebastian Ginzel, Arndt Borkhardt, Martine Muleris, Michael Gombert

Publikováno v: European Journal of Human Genetics
European Journal of Human Genetics, Nature Publishing Group, 2018, 26 (3), pp.440-444. ⟨10.1038/s41431-017-0071-5⟩

Constitutional mismatch repair deficiency (CMMRD) is an autosomal recessively inherited childhood cancer susceptibility syndrome caused by biallelic germline mutations in one of the mismatch repair (MMR) genes. The spectrum of CMMRD-associated tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9608fd9bf63c1ef0c72227b6627a182
https://doi.org/10.1038/s41431-017-0071-5

Survivin and XIAP – two potential biological targets in follicular thyroid carcinoma

Autor: Levent Dizdar, Sina C. Schütte, Pablo E. Verde, Andreas Krieg, Inga Nolten, C Driemel, Thomas A. Werner, Jasmin C. Riemer, Matthias Schott, Katharina Raba, Wolfram T. Knoefel, Sabrina Mersch, Stefan A. Topp

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports

Follicular thyroid carcinoma’s (FTC) overall good prognosis deteriorates if the tumour fails to retain radioactive iodine. Therefore, new druggable targets are in high demand for this subset of patients. Here, we investigated the prognostic and bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d223fce7d4badcf256ec47498d15ec69
http://link.springer.com/article/10.1038/s41598-017-11426-3

Survivin and XIAP: two valuable biomarkers in medullary thyroid carcinoma

Autor: Andreas Krieg, Jasmin C. Riemer, Kenko Cupisti, Wolfram T. Knoefel, Pablo E. Verde, Levent Dizdar, Achim Wolf, Thomas A. Werner, Yasemin Tamkan-Ölcek

Publikováno v: British Journal of Cancer

Background: Medullary thyroid carcinoma (MTC) accounts for ∼5% of all thyroid malignancies. To date, surgery is the first-line therapy with curative intention. However, for advanced MTC, conventional chemotherapeutic agents do not provide convincin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8bd4f5beef727db5ee5df9e0dc69bc
https://doi.org/10.1038/bjc.2016.5

Survivin and XIAP expression in distinct tumor compartments of surgically resected gastric cancer: XIAP as a prognostic marker in diffuse and mixed type adenocarcinomas

Autor: Andreas Krieg, Pablo E. Verde, Wolfram T. Knoefel, Monika Tomczak, Levent Dizdar, Nikolas H. Stoecklein, Thomas A. Werner, Jasmin C. Riemer, SA Safi

Publikováno v: Oncology letters. 14(6)

There is considerable evidence that the inhibitor of apoptosis protein (IAP) family serves a role in tumorigenesis. The most studied IAP family members, survivin and X-linked inhibitor of apoptosis (XIAP), have been demonstrated to serve as biomarker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77409797c97968f625e5b896a155efb5
https://pubmed.ncbi.nlm.nih.gov/29109763