Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jasmin, Fisher"'
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying homologous recombination deficiency can be identified using
Externí odkaz:
https://doaj.org/article/0a0c2b4d20e64cdfa2142eb02737b213
Autor:
Laure Talarmain, Matthew A. Clarke, David Shorthouse, Lilia Cabrera-Cosme, David G. Kent, Jasmin Fisher, Benjamin A. Hall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
HOXA9 plays an important role in acute myeloid leukaemia (AML), but its relevance for other blood malignancies is unclear. Here, the authors show that HOXA9 has a binary switch function that can clinically stratify AML patients, and model how the int
Externí odkaz:
https://doaj.org/article/5dbdffc27b334b189ae56094325547a0
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-6 (2022)
Diversity is a creative force that broadens views and enhances ideas; it increases productivity as well as the impact of our science, making our respective organisations more agile and timely. Equality of opportunity is a key to success for any resea
Externí odkaz:
https://doaj.org/article/434e33d17cb54f67a1ba509628f0fa1e
Autor:
Rowan Howell, Matthew A. Clarke, Ann-Kathrin Reuschl, Tianyi Chen, Sean Abbott-Imboden, Mervyn Singer, David M. Lowe, Clare L. Bennett, Benjamin Chain, Clare Jolly, Jasmin Fisher
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-13 (2022)
Abstract The COVID-19 pandemic has pushed healthcare systems globally to a breaking point. The urgent need for effective and affordable COVID-19 treatments calls for repurposing combinations of approved drugs. The challenge is to identify which combi
Externí odkaz:
https://doaj.org/article/138f70666aaf4bca914664c7e630f7d8
Autor:
Liora Haim-Vilmovsky, Johan Henriksson, Jennifer A Walker, Zhichao Miao, Eviatar Natan, Gozde Kar, Simon Clare, Jillian L Barlow, Evelina Charidemou, Lira Mamanova, Xi Chen, Valentina Proserpio, Jhuma Pramanik, Steven Woodhouse, Anna V Protasio, Mirjana Efremova, Julian L Griffin, Matt Berriman, Gordon Dougan, Jasmin Fisher, John C Marioni, Andrew N J McKenzie, Sarah A Teichmann
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251233 (2021)
The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an emphasis on Th2 cells, b
Externí odkaz:
https://doaj.org/article/3d39463ca138487e88bb41bb5b120a66
Autor:
Ali Sinan Köksal, Kirsten Beck, Dylan R. Cronin, Aaron McKenna, Nathan D. Camp, Saurabh Srivastava, Matthew E. MacGilvray, Rastislav Bodík, Alejandro Wolf-Yadlin, Ernest Fraenkel, Jasmin Fisher, Anthony Gitter
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3607-3618 (2018)
Summary: We present a method for automatically discovering signaling pathways from time-resolved phosphoproteomic data. The Temporal Pathway Synthesizer (TPS) algorithm uses constraint-solving techniques first developed in the context of formal verif
Externí odkaz:
https://doaj.org/article/48caac5bc5e443d090361032f80a4b17
Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling
Autor:
Rowan Howell, James Davies, Matthew A. Clarke, Anna Appios, Inês Mesquita, Yashoda Jayal, Ben Ringham-Terry, Isabel Boned Del Rio, Jasmin Fisher, Clare L. Bennett
Publikováno v:
Science Advances. 9
While skin is a site of active immune surveillance, primary melanomas often escape detection. Here, we have developed an in silico model to determine the local cross-talk between melanomas and Langerhans cells (LCs), the primary antigen-presenting ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8bafc2eb66cf9196d48018d1e75c375
https://doi.org/10.1126/sciadv.add1992
https://doi.org/10.1126/sciadv.add1992
Autor:
Jasmin Fisher, Jonathan Dry, Berthold Gottgens, Francoise Powell, Dennis Wang, Shaun Grosskurth, Dana Silverbush
Supplementary Materials and Methods: Cell line treatment Gene expression microarray Whole exome DNA sequencing Theranostics health reverse phase protein array Protein array data transformation for executable network model construction PhosphoScan pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9b383b82a5845707a9b2379f3f086d
https://doi.org/10.1158/0008-5472.22416533.v1
https://doi.org/10.1158/0008-5472.22416533.v1
Autor:
Jasmin Fisher, Jonathan Dry, Berthold Gottgens, Francoise Powell, Dennis Wang, Shaun Grosskurth, Dana Silverbush
The following tables are supplied in the excel file due to their sizes: Table S6. Phosphosite Overlap. PhosphoScan mass-spectrometry in MOLM16 cells after 3 hour treatment with AZD1208 Table S7. Literature Entries. Full literature entries. Table S8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb152958e30799e2310eea005ed16ab
https://doi.org/10.1158/0008-5472.22416530.v1
https://doi.org/10.1158/0008-5472.22416530.v1
Autor:
Jasmin Fisher, Jonathan Dry, Berthold Gottgens, Francoise Powell, Dennis Wang, Shaun Grosskurth, Dana Silverbush
Figure S1. A schematic representation for the method of transforming the log2 linear RPPA values to a 5 point categorical scale suitable for BMA modeling. Figure S2. Differential AML signaling responses to single agent PIM inhibition with AZD1208 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc8a130edd3747af7df20ce96d71686
https://doi.org/10.1158/0008-5472.22416536
https://doi.org/10.1158/0008-5472.22416536