Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jasim Kada Benotmane"'
Autor:
Jasim Kada Benotmane, Jan Kueckelhaus, Paulina Will, Junyi Zhang, Vidhya M. Ravi, Kevin Joseph, Roman Sankowski, Jürgen Beck, Catalina Lee-Chang, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Spatial resolution of the T cell repertoire is essential for deciphering cancer-associated immune dysfunction. Current spatially resolved transcriptomic technologies are unable to directly annotate T cell receptors (TCR). We present spatiall
Externí odkaz:
https://doaj.org/article/3bbd27aa3be14c8cb9783f3bdb460db0
Autor:
Jan Kueckelhaus, Simon Frerich, Jasim Kada-Benotmane, Christina Koupourtidou, Jovica Ninkovic, Martin Dichgans, Juergen Beck, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Spatially resolved transcriptomics has revolutionized RNA studies by aligning RNA abundance with tissue structure, enabling direct comparisons between histology and gene expression. Traditional approaches to identifying signature genes often
Externí odkaz:
https://doaj.org/article/5ddb7137c89d4ed887c861114fc3f3b6
Autor:
Simon P Behringer, Vidhya M Ravi, Oliver Schnell, Jasim Kada Benotmane, Henrike Salié, Marie Follo, Daniel Delev, Marius Schwabenland, Ulrich G. Hofmann, Melanie Boerries, Jonathan M Goeldner, Mohammed Khiat, Christian Fung, Manching Ku, Axel Walch, Jürgen Beck, Dieter Henrik Heiland, Ugne Kuliesiute, Florian Scherer, Ulrich Schüller, Paulina Will, Lea Vollmer, Na Sun, Pamela Franco, Roman Sankowski, Jasmin von Ehr, Kevin Joseph, Marco Prinz, Katrin Lamszus, Franz Ricklefs, Junyi Zhang, Jan Kueckelhaus, Saskia Killmer, Nicolas Neidert, Bertram Bengsch
Publikováno v:
Cancer cell, Cambridge, MA : Cell Press, 2022, vol. 40, iss. 6, p. 639-655, e1-e13
Cancer Cell 40, 639-655.e13 (2022)
Cancer Cell 40, 639-655.e13 (2022)
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of the dynamic reorganization within the spatial context of these tumors remains elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e8ee4dd63c97972bea35b3546493e
https://repository.vu.lt/VU:ELABAPDB139646810&prefLang=en_US
https://repository.vu.lt/VU:ELABAPDB139646810&prefLang=en_US
Autor:
Franz Ricklefs, Oliver Schnell, Vidyha Ravi, Dieter Henrik Heiland, Jürgen Beck, Kevin Joseph, Jan Kückelhaus, Jasim Kada Benotmane, Paulina Will
Publikováno v:
Neuro Oncol
High-dimensional technologies have provided insights into transcriptional heterogeneity and dynamic plasticity which are hallmarks of brain tumors. Although scRNA-seq recovers the diversity of transcriptional states, their spatial context within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944f552c8554f40d35af2a2020dd5dce
https://europepmc.org/articles/PMC8598897/
https://europepmc.org/articles/PMC8598897/
Publikováno v:
Neuro-Oncology. 24:vii277-vii277
Regional diversity of anti-tumor immunity in glioblastoma (GBM) has been poorly investigated due to technical limitations. To overcome these hurdles, we developed SPTCR-seq (SPatial TCell Receptor sequencing) to spatially profile T cell immune respon
Autor:
Roman Sankowski, Saskia Killmer, Kevin Joseph, Henrike Salié, Jonathan M Goeldner, Vidhya M Ravi, Marie Follo, Nicolas Neidert, Na Sun, Ulrich G. Hofmann, Florian Scherer, Simon P Behringer, Jasim Kada Benotmane, Jan Kekelhaus, Daniel Delev, Oliver Schnell, Lea Vollmer, Christian Fung, Jürgen Beck, Dieter Henrik Heiland, Paulina Will, Bertram Bengsch, Marco Prinz, Pamela Franco, Jasmin von Ehr, Axel Walch
Glioblastomas are highly malignant tumors of the central nervous system. Evidence suggests that these tumors display large intra- and inter-patient heterogeneity hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4874e0d1d05588b27fb7dddf6d13147d
https://doi.org/10.21203/rs.3.rs-244902/v1
https://doi.org/10.21203/rs.3.rs-244902/v1
Autor:
Oliver Schnell, Jasim Kada Benotmane, Dieter Henrik Heiland, Jürgen Beck, Vidyha Ravi, Kevin Joseph, Jan Kückelhaus
Publikováno v:
Neuro Oncol
The diversity to T cell responses and clonality in spatially heterogeneous glioblastoma is of paramount importance to explore underlying mechanisms of anti-tumor immunity. Spatial transcriptomics, a novel technology to map the transcriptional archite
Autor:
Jasim Kada Benotmane, Kevin Joseph, Jan Kückelhaus, Oliver Schnell, Dieter Henrik Heiland, Jürgen Beck, Vidyha Ravi, Paulina Will
Publikováno v:
Neuro Oncol
Glioblastomas are embedded into an immunosuppressive microenvironment resulting in limited success of immunotherapies. Although, we and others observed defined myeloid-tumor crosslinks reducing T cell homing and activation, the spatial context of the