Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Jasbir Seehra"'
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Data from ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth
Autor: Ravindra Kumar, Jasbir Seehra, Kathryn W. Underwood, R. Scott Pearsall, Jeffrey A. Ucran, Nicolas Solban, Travis E. Monnell, Roselyne Castonguay, Asya V. Grinberg, Aaron W. Mulivor, Eileen G. Pobre, Dianne Mitchell
Activin receptor–like kinase-1 (ALK1) is a type I, endothelial cell–specific member of the transforming growth factor-β superfamily of receptors known to play an essential role in modulating angiogenesis and vessel maintenance. In the present st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d62b66268345b52b0f0b8aa7db8311c
https://doi.org/10.1158/1535-7163.c.6532256
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7
Abstract 11209: KER-012, a Novel Modified ActrII Ligand Trap, Attenuated Cardiac Pathology in a Pulmonary Arterial Banding Model of Right Ventricle Overload
Autor: Keith Babbs, Chris Materna, ffolliott Fisher, Jasbir Seehra, Jennifer Lachey
Publikováno v: Circulation. 144
Pulmonary arterial hypertension (PAH) is a debilitating disorder, characterized by right ventricle (RV) pressure overload, cardiac hypertrophy, and progressive RV dysfunction. PAH is associated with unbalanced TGFß signaling, favoring signaling of S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7139b92311f7aa47c6a927a267e46ee2
https://doi.org/10.1161/circ.144.suppl_1.11209
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8
Ker-050, an Inhibitor of TGF- β Superfamily Signaling, Promoted Thrombopoiesis and Reversed Immune Thrombocytopenia in a Mouse Model of Disease
Autor: Jasbir Seehra, Jenn Lachey, Marina Feigenson, Joshua Lamora, Ffolliott Fisher, Claire C Tseng, Remya Nathan
Publikováno v: Blood. 138:2068-2068
KER-050 is a modified ActRIIA ligand trap that is designed to inhibit the activity of the TGF-β ligands, including activin A, activin B, GDF8 and GDF11, that act through the SMAD2/3 signaling cascade. Notably, in a Phase 1 clinical study we observed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ad49a1a651f25bb8ca197545ba45a52
https://doi.org/10.1182/blood-2021-152814
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9
Rker-050 Rescued Ruxolitinib (Rux)-Associated Reductions in Red Blood Cell Volume
Autor: Ffolliott Fisher, Remya Nathan, Claire C Tseng, Joshua Lamora, Jasbir Seehra, Marina Feigenson, Jenn Lachey
Publikováno v: Blood. 138:934-934
Myelofibrosis (MF) is characterized by the dysfunctional Janus kinase/signal transducers and activators of transcription signaling (JAK/STAT) pathways leading to progressive proliferation of granulocytic and megakaryocytic cells in the bone marrow at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4256a4c0f43692f2617d3219b1fbb05a
https://doi.org/10.1182/blood-2021-152729
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10
Ker-050, a Novel Inhibitor of Tgfβ Superfamily Signaling, Induces Red Blood Cell Production By Promoting Multiple Stages of Erythroid Differentiation
Autor: Marina Feigenson, Ffolliott Fisher, Claire C Tseng, Christopher Materna, Jenn Lachey, Evan Lema, Remya Nathan, Alana Gudelsky, Jasbir Seehra
Publikováno v: Blood. 136:34-34
Diseases such as myelodysplastic syndrome (MDS) and myelofibrosis (MF) are characterized by ineffective hematopoiesis resulting in one or multiple cytopenias. Disease-causing defects occur across multiple cell lineages and stages of hematopoiesis, ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5006c813bbd2b003b27e77c5bd173141
https://doi.org/10.1182/blood-2020-140364
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