Initial Studies with 11C-Vorozole PET Detect Overexpression of Intratumoral Aromatase in Breast Cancer

Autor: Mouna Tahmi, Krystal Airola, Jasbeer Dhawan, Jules Cohen, Anat Biegon, Kenneth R. Shroyer, Patrick Bonilla, Dinko Franceschi, Deborah Pareto

Publikováno v: J Nucl Med

Aromatase inhibitors are the mainstay of hormonal therapy in estrogen receptor–positive breast cancer, although the response rate is just over 50% and in vitro studies suggest that only two thirds of postmenopausal breast tumors overexpress aromata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e9f52422357860b98524ef99188edf
https://doi.org/10.2967/jnumed.119.231589

A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke

Autor: Marta M. Nawrocky, S. David Smith, Zhongchi Luo, Helene Benveniste, Jasbeer Dhawan, Anat Biegon

Publikováno v: Future Neurology. 6:823-834

Ischemic stroke triggers a massive, although transient, glutamate efflux and excessive activation of NMDA receptors (NMDARs), possibly leading to neuronal death. However, multiple clinical trials with NMDA antagonists failed to improve, or even worse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721226b528feb3581c9c8657062f92de
https://doi.org/10.2217/fnl.11.55

Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1

Autor: Lynn Hlatky, M. A. Suresh Kumar, Upasna Thapar, Krishnan Manickam, Pankaj Chaudhary, Afshin Beheshti, Jasbeer Dhawan, Mohan Natarajan, Michael J. Peluso, Bruce Demple, Mamta D. Naidu, Louis A. Peña

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0133016 (2015)
PLoS ONE
Suresh Kumar, M A, Peluso, M, Chaudhary, P, Dhawan, J, Beheshti, A, Manickam, K, Thapar, U, Pena, L, Natarajan, M, Hlatky, L, Demple, B & Naidu, M 2015, ' Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits,and Alterations in Apurinic Endonuclease 1 ', PLoS ONE, vol. 10, no. 7, e0133016 . https://doi.org/10.1371/journal.pone.0133016

Ionizing radiation causes degeneration of myelin, the insulating sheaths of neuronal axons, leading to neurological impairment. As radiation research on the central nervous system has predominantly focused on neurons, with few studies addressing the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719072d425fc2e19caa4bb33e52e5719
http://europepmc.org/articles/PMC4514622?pdf=render

D-cycloserine improves functional outcome after traumatic brain injury with wide therapeutic window

Autor: Amos Olufemi Adeleye, Victoria Trembovler, Yigal Shoshan, Rami Yaka, Anat Biegon, Dean Nachman, Esther Shohami, Alexander G. Alexandrovich, Jasbeer Dhawan

Publikováno v: European journal of pharmacology. 629(1-3)

It has been long thought that hyperactivation of N-methyl- d -aspartate (NMDA) receptors underlies neurological decline after traumatic brain injury. However, all clinical trials with NMDA receptor antagonists failed. Since NMDA receptors are down-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197007931006d5bc36300fb564173632
https://pubmed.ncbi.nlm.nih.gov/19958766

Preparation of radioiodinated peptide nucleic acids with high specific activity

Autor: Jasbeer Dhawan, Anna Lovejoy, Adriana Tovar-Salazar, Q. Alison Liu, Andrew N. Gifford

Publikováno v: Analytical biochemistry. 360(1)

Peptide nucleic acids (PNAs) have stronger affinity and greater specificity than do oligonucleotides for binding to DNA and RNA and, as such, have potential utility as probes in molecular biology applications. In this study, a novel approach for labe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179254b3f302ef5bac495d1c6b2ebf4e
https://pubmed.ncbi.nlm.nih.gov/17094934