The cross-pathway control system regulates production of the secondary metabolite toxin, sirodesmin PL, in the ascomycete, Leptosphaeria maculans

Autor: Fox Ellen M, Elliott Candace E, Jarvis Renee S, Howlett Barbara J

Publikováno v: BMC Microbiology, Vol 11, Iss 1, p 169 (2011)

Abstract Background Sirodesmin PL is a secondary metabolite toxin made by the ascomycetous plant pathogen, Leptosphaeria maculans. The sirodesmin biosynthetic genes are clustered in the genome. The key genes are a non-ribosomal peptide synthetase, si

Externí odkaz: https://doaj.org/article/0017922a525542719b3ae052716b3c4b

Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.

Autor: Van de Poël A; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Toledo-Sherman L; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Breccia P; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Cachope R; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Bate JR; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Angulo-Herrera I; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Wishart G; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Matthews KL; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Martin SL; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Peacock M; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Barnard A; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Cox HC; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Jones G; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., McAllister G; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Vater H; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Esmieu W; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clissold C; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Lamers M; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Leonard P; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Jarvis RE; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Blackaby W; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Eznarriaga M; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Lazari O; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Yates D; Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Rose M; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Jang SW; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Muñoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 5018-5036. Date of Electronic Publication: 2021 Mar 30.

Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.

Autor: Toledo-Sherman L; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Breccia P; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Cachope R; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Bate JR; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Angulo-Herrera I; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Wishart G; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Matthews KL; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Martin SL; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Cox HC; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., McAllister G; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Penrose SD; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Vater H; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Esmieu W; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Van de Poël A; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Van de Bospoort R; Charles River , Leiden 2333 CR , Netherlands., Strijbosch A; Charles River , Leiden 2333 CR , Netherlands., Lamers M; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Leonard P; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Jarvis RE; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Blackaby W; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Barnes K; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Eznarriaga M; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Dowler S; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Smith GD; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Fischer DF; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Lazari O; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Yates D; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Rose M; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Jang SW; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Muñoz-Sanjuan I; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Dominguez C; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Mar 28; Vol. 62 (6), pp. 2988-3008. Date of Electronic Publication: 2019 Mar 19.

Inter- and intramolecular annulation strategies to a cyclopentanone building block containing an all-carbon quaternary stereogenic center.

Autor: Penrose SD; †BioFocus, a Charles River Company, Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Stott AJ; †BioFocus, a Charles River Company, Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Breccia P; †BioFocus, a Charles River Company, Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Haughan AF; †BioFocus, a Charles River Company, Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Bürli RW; †BioFocus, a Charles River Company, Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Jarvis RE; †BioFocus, a Charles River Company, Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, United Kingdom., Dominguez C; ‡CHDI Management/CHDI Foundation Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.

Publikováno v: Organic letters [Org Lett] 2015 Mar 20; Vol. 17 (6), pp. 1401-4. Date of Electronic Publication: 2015 Feb 27.

Physiotherapy for children and young adults with arthritis.

Autor: Jarvis RE

Publikováno v: Physiotherapy [Physiotherapy] 1978 May; Vol. 64 (5), pp. 143-5.