AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.

Autor: Jarrod S Johnson, Martina Gentzsch, Liqun Zhang, Carla M P Ribeiro, Boris Kantor, Tal Kafri, Raymond J Pickles, R Jude Samulski

Publikováno v: PLoS Pathogens, Vol 7, Iss 5, p e1002053 (2011)

Barriers to infection act at multiple levels to prevent viruses, bacteria, and parasites from commandeering host cells for their own purposes. An intriguing hypothesis is that if a cell experiences stress, such as that elicited by inflammation, endop

Externí odkaz: https://doaj.org/article/2b7946ef397d4a6e8d1c9ac73552aa52

Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

Autor: Joseph R Casalini, Chelsea U Kidwell, Soorya Pradeep, Sandra D Scherer, Daniel Greiner, Defne Bayik, Dionysios C Watson, Gregory S Olson, Justin D Lathia, Jarrod S Johnson, Jared Rutter, Alana L Welm, Thomas A Zangle, Minna Roh-Johnson

Publikováno v: eLife. 12

Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from one cell to another, can affect cellular and tissue homeostasis. Most of what we know about mitochondrial transfer stems from bulk cell studies and have led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96155be7ecb6a6ee549e87a03cc9f933
https://doi.org/10.7554/elife.85494

A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV

Autor: Nicholas De Veaux, Victor Garcia-Paredes, Mickaël M. Ménager, Xavier Lahaye, Lynn M. Amon, Jarrod S. Johnson, Alexander W. Rives, Marine Luka, Dan R. Littman, Nicolas Manel, Richard Bonneau, Brieuc P. Perot, Alan Aderem, Sasha Y. Lucas, Aaron Watters, Ghaith Abdessalem

Publikováno v: Cell Reports, Vol 30, Iss 3, Pp 914-931.e9 (2020)
Cell Reports
Cell Reports, Elsevier Inc, 2020, 30 (3), pp.914-931.e9. ⟨10.1016/j.celrep.2019.12.054⟩
Cell reports

SUMMARY Transcriptional programming of the innate immune response is pivotal for host protection. However, the transcriptional mechanisms that link pathogen sensing with innate activation remain poorly under-stood. During HIV-1 infection, human dendr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ae1010a372c29774cf8995666e7724
http://www.sciencedirect.com/science/article/pii/S2211124719317115

Liver stage malaria infection is controlled by host regulators of lipid peroxidation

Autor: Alexis Kaushansky, Jarrod S. Johnson, Denali R. Dudgeon, Samantha L Whiteside, Kelly R. Stevens, Elizabeth K.K. Glennon, Adam J. Lewis, Meghan Zuck, Nadia Arang, Chelsea L. Fortin, Kamalakannan Vijayan, Alan Aderem, Alyse N. Douglass, Heather S. Kain

Publikováno v: Cell Death and Differentiation

The facets of host control during Plasmodium liver infection remain largely unknown. We find that the SLC7a11-GPX4 pathway, which has been associated with the production of reactive oxygen species, lipid peroxidation, and a form of cell death called

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffef563e01714ec8924977783ef964f
https://doi.org/10.1038/s41418-019-0338-1

Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro

Autor: Owen Pornillos, Wesley I. Sundquist, Jarrod S. Johnson, Barbie K. Ganser-Pornillos, Devin E. Christensen

Publikováno v: Science

HIV-1 replication and integration in vitro To infect a host cell, HIV-1 must reverse transcribe its single-stranded RNA genome into a double-stranded DNA copy and integrate that copy into a host chromosome. Reverse transcription and integration have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d85f75001c4bed0f589e495146813b9
https://europepmc.org/articles/PMC8022914/