Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Jarrod J, Sandow"'
Autor:
Shannon Nicolson, Jantina A. Manning, Yoon Lim, Xin Jiang, Erica Kolze, Sonia Dayan, Ruchi Umargamwala, Tianqi Xu, Jarrod J. Sandow, Andrew I. Webb, Sharad Kumar, Donna Denton
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-24 (2024)
Abstract Autophagy, the process of elimination of cellular components by lysosomal degradation, is essential for animal development and homeostasis. Using the autophagy-dependent Drosophila larval midgut degradation model we identified an autophagy r
Externí odkaz:
https://doaj.org/article/48b9fe21c5fc45f2b5b559b3895df865
Autor:
Kirti Pandey, Stacie S. Wang, Nicole A. Mifsud, Pouya Faridi, Alexander J. Davenport, Andrew I. Webb, Jarrod J. Sandow, Rochelle Ayala, Michelle Monje, Ryan S. Cross, Sri H. Ramarathinam, Misty R. Jenkins, Anthony W. Purcell
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionDiffuse intrinsic pontine glioma (DIPG), recently reclassified as a subtype of diffuse midline glioma, is a highly aggressive brainstem tumor affecting children and young adults, with no cure and a median survival of only 9 months. Conven
Externí odkaz:
https://doaj.org/article/cca9faeeedb64a64829693d53680c424
Autor:
Yanxiang Meng, Christopher R. Horne, Andre L. Samson, Laura F. Dagley, Samuel N. Young, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-12 (2022)
Abstract Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3. To mediate necroptosis, RIPK3 must stably interact with
Externí odkaz:
https://doaj.org/article/cbe0b2a830d34eb4ad810da967695163
Autor:
Katherine R. Martin, Jessica A. Day, Jacinta A. Hansen, Damian B. D'Silva, Huon L. Wong, Alexandra Garnham, Jarrod J. Sandow, Brunda Nijagal, Nicholas Wilson, Ian P. Wicks
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Background Low‐density neutrophils (LDN) are a distinct subset of neutrophils rarely detected in healthy people but appear in the blood of patients with autoimmune diseases, including systemic lupus erythematosus (SLE), and are mobilised i
Externí odkaz:
https://doaj.org/article/648482c20dd24a699ab19a8a10115a5e
Autor:
Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet. Here, the authors present the crystal structures of the human RIPK3:MLKL complex and hu
Externí odkaz:
https://doaj.org/article/c906a3851c864c11bf414f6e8e863c7b
Autor:
Daniel Frank, Sarah E. Garnish, Jarrod J. Sandow, Ashley Weir, Lin Liu, Elise Clayer, Lizeth Meza, Maryam Rashidi, Simon A. Cobbold, Simon R. Scutts, Marcel Doerflinger, Holly Anderton, Kate E. Lawlor, Najoua Lalaoui, Andrew J. Kueh, Vik Ven Eng, Rebecca L. Ambrose, Marco J. Herold, Andre L. Samson, Rebecca Feltham, James M. Murphy, Gregor Ebert, Jaclyn S. Pearson, James E. Vince
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104632- (2022)
Summary: Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of R
Externí odkaz:
https://doaj.org/article/3caa971ec6024a6691ed27fdce5d0571
Autor:
Sarah E. Garnish, Yanxiang Meng, Akiko Koide, Jarrod J. Sandow, Eric Denbaum, Annette V. Jacobsen, Wayland Yeung, Andre L. Samson, Christopher R. Horne, Cheree Fitzgibbon, Samuel N. Young, Phoebe P. C. Smith, Andrew I. Webb, Emma J. Petrie, Joanne M. Hildebrand, Natarajan Kannan, Peter E. Czabotar, Shohei Koide, James M. Murphy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mixed Lineage Kinase Domain-Like (MLKL) pseudokinase is phosphorylated by RIPK3 kinase prior to cell death by necroptosis. Here, the authors use monobodies that bind to the MLKL pseudokinase domain as tools, which allowed them to determine the crysta
Externí odkaz:
https://doaj.org/article/09c7c00c35d347a0a64667b29956b651
Autor:
Michael R. Oliver, Christopher R. Horne, Safal Shrestha, Jeremy R. Keown, Lung-Yu Liang, Samuel N. Young, Jarrod J. Sandow, Andrew I. Webb, David C. Goldstone, Isabelle S. Lucet, Natarajan Kannan, Peter Metcalf, James M. Murphy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The viral Protein Kinase-1 (PK-1) phosphorylates the regulatory protein p6.9, which facilitates baculoviral genome release. Here, the authors combine X-ray crystallography with biophysical and biochemical analyses as well as molecular dynamics simula
Externí odkaz:
https://doaj.org/article/68962591ebc346e3865840990c4f686b
Autor:
Ammara Usman Farooq, Kelly Gembus, Jarrod J. Sandow, Andrew Webb, Suresh Mathivanan, Jantina A. Manning, Sonia S. Shah, Natalie J. Foot, Sharad Kumar
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 2, Pp n/a-n/a (2022)
Abstract Extracellular vesicles (EVs) are important mediators of intercellular communication. However, EV biogenesis remains poorly understood. We previously defined a role for Arrdc4 (Arrestin domain containing protein 4), an adaptor for Nedd4 famil
Externí odkaz:
https://doaj.org/article/b700be43fffc47aca0fe090c32c99f2e
Autor:
Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Wayland Yeung, Diane Coursier, Richard W. Birkinshaw, Jarrod J. Sandow, Wil I. L. Lehmann, Lung-Yu Liang, Isabelle S. Lucet, James D. Chalmers, Wayne M. Patrick, Natarajan Kannan, Emma J. Petrie, Peter E. Czabotar, James M. Murphy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineag
Externí odkaz:
https://doaj.org/article/b93b0f25bce74b3387360f9736d00ebc