Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jarrod J, Mousa"'
Autor:
Karen J. Gonzalez, Jiachen Huang, Miria F. Criado, Avik Banerjee, Stephen M. Tompkins, Jarrod J. Mousa, Eva-Maria Strauch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Many pathogenic viruses rely on class I fusion proteins to fuse their viral membrane with the host cell membrane. To drive the fusion process, class I fusion proteins undergo an irreversible conformational change from a metastable prefusion
Externí odkaz:
https://doaj.org/article/b33912e6e947435080cfc174c6b61717
Autor:
John V. Dzimianski, Julianna Han, Giuseppe A. Sautto, Sara M. O’Rourke, Joseph M. Cruz, Spencer R. Pierce, Jeffrey W. Ecker, Michael A. Carlock, Kaito A. Nagashima, Jarrod J. Mousa, Ted M. Ross, Andrew B. Ward, Rebecca M. DuBois
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally optimized broadly reactive antigen (COBRA)
Externí odkaz:
https://doaj.org/article/d3b5f9c02ac24ad48239a2e279933c19
Autor:
Ian A. Durie, Zahra R. Tehrani, Elif Karaaslan, Teresa E. Sorvillo, Jack McGuire, Joseph W. Golden, Stephen R. Welch, Markus H. Kainulainen, Jessica R. Harmon, Jarrod J. Mousa, David Gonzalez, Suzanne Enos, Iftihar Koksal, Gurdal Yilmaz, Hanife Nur Karakoc, Sanaz Hamidi, Cansu Albay, Jessica R. Spengler, Christina F. Spiropoulou, Aura R. Garrison, Mohammad M. Sajadi, Éric Bergeron, Scott D. Pegan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
There are currently no approved treatments for Crimean-Congo Hemorrhagic Fever Virus (CCHFV) infection. In this study, the authors structurally characterize the epitope targeted by protective non-neutralizing mouse and human antibodies and provide in
Externí odkaz:
https://doaj.org/article/ab186bd397154dcabe6fc31995264ac7
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two leading causes of severe respiratory infections in children, the elderly, and immunocompromised patients. The fusion (F) protein is the major target of neutralizing antibodies
Externí odkaz:
https://doaj.org/article/c1774d02e4394f92ba04e2b0d549a41f
Publikováno v:
Viruses, Vol 15, Iss 2, p 476 (2023)
Human metapneumovirus (hMPV) is an important cause of respiratory disease in immunocompromised individuals, yet hMPV infection has not been modeled before in immunocompromised animals. In this work, cotton rats S. hispidus immunosuppressed by cycloph
Externí odkaz:
https://doaj.org/article/72300d55b1a9440fad55fae81e7ca724
Autor:
Aaron D. Gingerich, Jarrod J. Mousa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The gram-positive bacterium Streptococcus pneumoniae is a leading cause of pneumonia, otitis media, septicemia, and meningitis in children and adults. Current prevention and treatment efforts are primarily pneumococcal conjugate vaccines that target
Externí odkaz:
https://doaj.org/article/215feca0e5b34769828a4ec66aa74df6
Publikováno v:
Viruses, Vol 15, Iss 2, p 347 (2023)
Computationally optimized broadly reactive antigens (COBRAs) are a next-generation universal influenza vaccine candidate. However, how these COBRAs induce antibody responses when combined with different adjuvants has not previously been well-characte
Externí odkaz:
https://doaj.org/article/79672edad3704cb5b2f7b93efec6d965
Autor:
Nada Abbadi, Jarrod J. Mousa
Publikováno v:
Viruses, Vol 15, Iss 1, p 200 (2023)
Neuraminidase (NA) is an important surface protein on influenza virions, playing an essential role in the viral life cycle and being a key target of the immune system. Despite the importance of NA-based immunity, current vaccines are focused on the h
Externí odkaz:
https://doaj.org/article/de99ff1368414d0fabb1227295e097d0
Autor:
Ahmet Ozdilek, Jiachen Huang, Rachelle Babb, Amy V. Paschall, Dustin R. Middleton, Jeremy A. Duke, Liise-anne Pirofski, Jarrod J. Mousa, Fikri Y. Avci
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Infectious diseases caused by pathogenic bacteria are a major threat to human health. Capsular polysaccharides (CPSs) of many pathogenic bacteria have been used as the main components of glycoconjugate vaccines against bacterial diseases in clinical
Externí odkaz:
https://doaj.org/article/bb58032aba484ba29def28d000156c12
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008942 (2020)
Human metapneumovirus (hMPV) is a leading cause of viral respiratory infection in children, and can cause severe lower respiratory tract infection in infants, the elderly, and immunocompromised patients. However, there remain no licensed vaccines or
Externí odkaz:
https://doaj.org/article/0b622c80f4b045cbb123fd382293faca